Results 41 to 50 of about 1,175,457 (250)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Concentration of aggregates with equivalent spherical diameters greater than 0.5 mm TT012_5-LAPS9

open access: yes, 2003
Concentration of aggregates with equivalent spherical diameters greater than 0.5 mm TT012_5 ...
Walsh, Ian D, Ian D Walsh (7888025)
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Comparison of mean (± SD) change in manifest refractive spherical equivalent.

open access: yes, 2022
Comparison of mean (± SD) change in manifest refractive spherical equivalent.
Kazuhiko Ohnuma (13531461)   +3 more
core   +1 more source

The Association of Central corneal thickness with Intra-ocular Pressure and Refractive Error in a Nigerian Population

open access: yesOnline Journal of Health & Allied Sciences, 2008
The purpose of this study was to determine the variation of central corneal thickness (CCT) with intraocular pressure (IOP) and spherical equivalent refractive error.
Eghosasere Iyamu, Misan Memeh
doaj  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Iteratively Reweighted Spherical Equivalent Source Method for Acoustic Source Identification

open access: yesIEEE Access, 2019
Spherical equivalent source method (S-ESM) using rigid spherical microphone arrays can simultaneously identify sound sources in all directions. In this paper, based on the reweighting and sparse representation frameworks, the sparsity-promoting ...
Guoli Ping   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

“Influence of Clinically Active Graves’ Ophthalmopathy on Spherical Equivalent and Visual Acuity”

open access: yes, 2022
Jasenka Petrovic Jurcevic,1 Marko Jurcevic,2 Mateja Jagic,3 Anamarija Jazbec,4 Kresimir Mandic,5 Jelena Juri Mandic5 1Medical School University of Zagreb, PhD Candidate on the Programme “Biomedicine and Health”, Zagreb, Croatia; 2University of Zagreb ...
Mandic K   +5 more
core  

Agreement Between Non-Cycloplegic Photorefraction and Retinoscopy in Pediatric Refraction

open access: yesLife
Accurate assessment of refractive error in children is essential for clinical decision-making, yet agreement between non-cycloplegic techniques remains uncertain, particularly due to differences in accommodative demand. This study evaluated the agreement
Ana Roque   +4 more
doaj   +1 more source

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