Results 31 to 40 of about 1,183,554 (295)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2021 U ovom su diplomskom radu opisani osnovni pojmovi sferne geometrije, te su navedeni osnovni teoremi i definicije spomenutog područja matematike. Redom su opisana osnovna svojstva sferne geometrije, sferna trigonometrija, sferna gibanja te konačno ...
Pižir, Kristijan
core
On the Geometry of Spherical Trochoids
KoG, 2023 We provide a synthetic study of the top-views of spherical trochoids. These projections turn out to be higher trochoids, i.e., curves generated by the superposition of more than two rotations. Special shapes of these trochoids show up for special choices of the spherical radii of the rolling circles.
Walther Jank +2 more
openaire +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
An Application of Spherical Geometry to Hyperkähler Slices [PDF]
Canadian Journal of Mathematics, 2020 AbstractThis work is concerned with Bielawski’s hyperkähler slices in the cotangent bundles of homogeneous affine varieties. One can associate such a slice with the data of a complex semisimple Lie group $G$, a reductive subgroup $H\subseteq G$, and a Slodowy slice $S\subseteq \mathfrak{g}:=\text{Lie}(G)$, defining it to be the hyperkähler quotient of $
Crooks, P., Pruijssen, M.L.A. van
openaire +4 more sources
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
A three-dimensional finite element model of cAMP signals
Forces in Mechanics, 2021 This paper presents a three-dimensional finite element model for cyclic adenosine monophosphate (cAMP) signaling. Governing equations for the synthesis, diffusion, and degradation of cAMP were numerically implemented using the finite element method ...
R. Warren +3 more
doaj +1 more source
Metric-Affine Geometries with Spherical Symmetry [PDF]
Symmetry, 2020 We provide a comprehensive overview of metric-affine geometries with spherical symmetry, which may be used in order to solve the field equations for generic gravity theories which employ these geometries as their field variables. We discuss the most general class of such geometries, which we display both in the metric-Palatini formulation and in the ...
openaire +3 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source