Results 31 to 40 of about 66,487 (261)

Ultra-broadband axicon transducer for optoacoustic endoscopy

Scientific Reports, 2021
Image performance in optoacoustic endoscopy depends markedly on the design of the transducer employed. Ideally, high-resolution performance is required over an expanded depth of focus.
Zakiullah Ali, Christian Zakian, Vasilis Ntziachristos   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Spherical Steiner Symmetrizations

Axioms
In this paper, we primarily investigate and establish several properties of spherical Steiner symmetrizations, along with the isoperimetric property of the spherical cap in Sn.
Youjiang Lin, Zhilang Deng
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Impact of geometry and magneto-optical properties on field enhancement and optical bistability in core–shell nanoparticles

Journal of Theoretical and Applied Physics, 2018
We study the interaction of electromagnetic field with two of the most tunable nanostructure geometries for nanoplasmonics including the magneto-optical nanoshell structure and the spheroidal geometry. We investigate the effect of combining both geometry
Tayebeh Naseri, Fatemeh Pourkhavari
doaj   +1 more source

Metric-Affine Geometries with Spherical Symmetry [PDF]

Symmetry, 2020
We provide a comprehensive overview of metric-affine geometries with spherical symmetry, which may be used in order to solve the field equations for generic gravity theories which employ these geometries as their field variables. We discuss the most general class of such geometries, which we display both in the metric-Palatini formulation and in the ...
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A History of mathematics and the previous knowledge of teachers as grants for planning a course on geometry ball and hyperbolic

Amazônia, 2014
The aim of this research was to study how the historical development of mathematics, with the backdrop of the evolution of geometry, can assist in the continuing education of mathematics’ teachers.
Wanderley Pivatto Brum
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Assessing the Accuracy of 2‐D Planetary Evolution Models Against the 3‐D Sphere

Geochemistry, Geophysics, Geosystems
Regardless of the steady increase of computing power during the last decades, numerical models in a 3D spherical shell are only used in specific setups to investigate the thermochemical convection in planetary interiors, while 2D geometries are typically
A. Fleury, A.‐C. Plesa, C. Hüttig, D. Breuer   +3 more
doaj   +1 more source