Results 71 to 80 of about 147,239 (238)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Mapping neutron biological effectiveness for DNA damage induction as a function of incident energy and depth in a human sized phantom

Scientific Reports
We present new developments for an ab-initio model of the neutron relative biological effectiveness (RBE) in inducing specific classes of DNA damage.
Alice Mentana, Virgilio Quaresima, Pavel Kundrát, Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, Andrea Previtali, Giorgia Santi Amantini, Luca Lunati, Virginia Boretti, Livio Narici, Luca Di Fino, Luca Bocchini, Claudio Cipriani, Giorgio Baiocco   +14 more
doaj   +1 more source

Spherical Branes

, 2018
We construct new solutions of ten-dimensional supergravity with sixteen supercharges which describe the backreaction of D$p$-branes with spherical worldvolume.
Bobev, Nikolay, Bomans, Pieter, Gautason, Fridrik Freyr   +2 more
core   +1 more source

The multilinear spherical maximal function in one dimension

Proceedings of the Edinburgh Mathematical Society
AbstractIn dimension n = 1, we obtain $L^{p_1}(\mathbb R) \times\dots\times L^{p_m}(\mathbb R)$ to $L^p(\mathbb R)$ boundedness for the multilinear spherical maximal function in the largest possible open set of indices and we provide counterexamples that indicate the optimality of our results.
Georgios Dosidis, João P. G. Ramos
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

𝐿^{𝑝} bound on the strong spherical maximal function

Proceedings of the American Mathematical Society
In this note we show that the strong spherical maximal function in R d \mathbb R^d is bounded on L p L^p if p > 2 ( d + 1 ) / ( d − 1 ) p>2(d+
Lee, Juyoung, Lee, Sanghyuk, Oh, Sewook
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Twisted bilinear spherical maximal functions

We obtain $L^p-$estimates for the full and lacunary maximal functions associated to the twisted bilinear spherical averages given by \[\mathfrak{A}_t(f_1,f_2)(x,y)=\int_{\mathbb S^{2d-1}}f_1(x+tz_1,y)f_2(x,y+tz_2)\;dσ(z_1,z_2),\;t>0,\] for all dimensions $d\geq1$.
Bhojak, Ankit, Choudhary, Surjeet Singh, Shrivastava, Saurabh   +2 more
openaire   +2 more sources

Weighted estimates for fractional maximal functions related to spherical means [PDF]

Bulletin of the Australian Mathematical Society, 2002
We prove weighted Lp-Lq estimates for the maximal operators ℳα, given by , where μt denotes the normalised surface measure on the sphere of centre 0 and radius t in Rd. The techniques used involve interpolation and the Mellin transform. To do this, we also prove weighted Lp-Lq estimates for the operators of convolution with the kernels |·|−α−iη.
Cowling, Michael, Garcia-Cuerva, Jose, Gunawan, Hendra   +2 more
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source