Results 61 to 70 of about 147,239 (238)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Boundedness of Commutators Generated by the Rough Fractional Maximal Operator on Variable Exponent Central Morrey Spaces

Axioms
In this paper, using harmonic analysis tools−including spherical harmonic decomposition of kernels, sharp maximal function estimates, and variable exponent space theory—we investigate the boundedness of the commutator [b,MΩ,β] on variable exponent ...
Yuhe Yang, Zhenzhen Yang, Suixin He
doaj   +1 more source

On the Solution Space of Differentially Rotating Neutron Stars in General Relativity

, 2009
A highly accurate, multi-domain spectral code is used in order to construct sequences of general relativistic, differentially rotating neutron stars in axisymmetry and stationarity.
Ansorg, Marcus, Gondek-Rosińska, Dorota, Villain, Loïc   +2 more
core   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Sonochemical synthesis of gold nanoparticles mediated by potato starch: Its performance in the treatment of esophageal cancer

Open Chemistry
Economically viable and eco-friendly potato starch (PS) was employed to synthesize Au NPs under ultrasound irradiation. PS phytochemicals have the function of a green reductant as well as an efficient stabilizer template to cap and synthesize gold ...
Liu Mingwei, Xue Xiaolei, Karmakar Bikash, Eltantawy Waleed, El-kott Attalla F., El. Nashar Emam M., Abd-Ella Eman M.   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Meshfree modelling of magnetotelluric and controlled-source electromagnetic data for conductive earth models with complex geometries

Frontiers in Earth Science
Geophysical electromagnetic survey methods are particularly effective in locating conductive mineral deposits or mineralization zones in a mineral resource exploration.
Jianbo Long
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Estimation of Maximum Obtainable RBE ‘Turnover-Points’ (LET_U) for Accelerated Ions Based on a Nuclear Charge Radius Hypothesis to Obtain Iso-Effective LET and RBE Values

Biophysica
Purpose: The purpose of this study is to analyze the relationship between nuclear charge (Z), atomic mass (A), LET (linear energy transfer for maximal relative biological effectiveness (RBE)) for accelerated ions based on the hypothesis that for each ion,
Bleddyn Jones
doaj   +1 more source

A Polynomial Based Approach to Extract Fiber Directions from the ODF and its Experimental Validation [PDF]

, 2009
International audienceIn Diffusion MRI, spherical functions are commonly employed to represent the diffusion information. The ODF is an intuitive spherical function since its maxima are aligned with the dominant fiber directions.
Deriche, Rachid, Descoteaux, Maxime, Ghosh, Aurobrata, Tsigaridas, Elias P.,   +3 more
core   +2 more sources