Results 21 to 30 of about 1,761,902 (161)
Frontiers in Genetics, 2019 Neuronal Ceroid Lipofuscinoses (NCLs) are progressive degenerative diseases mainly affect brain and retina. They are characterized by accumulation of autofluorescent storage material, mitochondrial ATPase subunit C, or sphingolipid activator proteins A ...
Xiao-Tun Ren +8 more
doaj +1 more source
Sphingolipid-Transporting Proteins as Cancer Therapeutic Targets [PDF]
, 2019 This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.The understanding of the role of sphingolipid metabolism in cancer has tremendously increased in the past ten years.
Arenz, Christoph +9 more
core +1 more source
, 2022 International audienceSphingolipids are ubiquitous lipids found in all mammalian cell membranes and in plasma lipoproteins. Many exhibit dual functions, as key structural elements, but also as modulators of biological/physiological functions ...
Caillaud, Catherine +2 more
core +1 more source
The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin [PDF]
The EMBO Journal, 2003 Most soluble lysosomal proteins bind the mannose 6-phosphate receptor (M6P-R) to be sorted to the lysosomes. However, the lysosomes of I-cell disease (ICD) patients, a condition resulting from a mutation in the phosphotransferase that adds mannose 6-phosphate to hydrolases, have near normal levels of several lysosomal proteins, including the ...
Stephane, Lefrancois +4 more
openaire +2 more sources
Orm family proteins mediate sphingolipid homeostasis [PDF]
, 2010 Despite the essential roles of sphingolipids both as structural components of membranes and critical signalling molecules, we have a limited understanding of how cells sense and regulate their levels.
Ruedi Aebersold +28 more
core +1 more source
Mechanisms of sphingolipid functions during heat stress in "Saccharomyces cerevisiae" [PDF]
, 2005 Sphingolipids are important membrane constituents in all eukaryotic cells. Ongoing sphingolipid synthesis is required for a variety of cellular processes including response to heat shock.
Meier, Karsten D.
core +1 more source
CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation [PDF]
Autophagy, 2018 The macroautophagy/autophagy and inflammasome pathways are linked through their roles in innate immunity and chronic inflammatory disease. Ceramide-1-phosphate (C1P) is a bioactive sphingolipid that regulates pro-inflammatory eicosanoid production. Whether C1P also regulates autophagy and inflammasome assembly/activation is not known. Here we show that
Shrawan Kumar Mishra +5 more
openaire +3 more sources
Sphingolipid metabolism dysfunctions [PDF]
, 2018 Sfingolipidi su glavne komponente staničnih membrana u živčanom sustavu svih eukariota. S obzirom da su uklopljeni u stanične membrane, oni kontroliraju i bitne stanične signalne puteve.
Hefer, Marija
core +2 more sources
Do Sphingolipids Control Viral Membrane Protein Activity? [PDF]
Biophysical Journal, 2011 The membrane-behaviour of the matrix (M) protein from respiratory syncytical virus, a prototypical enveloped virus, has been characterised by surface techniques (tensiometry, Brewster angle microscopy and atomic force microscopy) and experiments using lipid bilayers (FRET, light microscopy).
Sanderson, John M. +3 more
openaire +1 more source
List of putative FFAT-like domains found in proteins related to the sphingolipid synthesis.
, 2018 List of putative FFAT-like domains found in proteins related to the sphingolipid synthesis.
Peter Mattjus (437084) +5 more
core +1 more source