Results 31 to 40 of about 1,761,902 (161)

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Sphingolipid activator proteins: proteins with complex functions in lipid degradation and skin biogenesis [PDF]

Glycobiology, 2001
Sphingolipid activator proteins (SAPs or saposins) are essential cofactors for the lysosomal degradation of membrane-anchored sphingolipids. Four of the five known proteins of this class, SAPs A--D, derive from a single precursor protein and show high homology, whereas the fifth protein, GM2AP, is larger and displays a different secondary structure ...
Schuette, C. G., Pierstorff, B., Huettler, S., Sandhoff, K.   +3 more
openaire   +3 more sources

Analysis of the multiple forms of Gaucher spleen sphingolipid activator protein 2 [PDF]

Biochemical Journal, 1988
Gaucher spleen sphingolipid activator protein 2 was fractionated into concanavalin A binding- and non-binding fractions. These fractions each contained several bands on non-denaturing polyacrylamide gel electrophoresis (PAGE). The two fractions were further fractionated by electroblotting the proteins from preparative gels onto nitrocellulose, staining
B C, Paton, A, Poulos
openaire   +2 more sources

Identification of novel sphingolipid-binding motifs in mammalian membrane proteins

, 2014
Specific interactions between transmembrane proteins and sphingolipids is a poorly understood phenomenon, and only a couple of instances have been identified.
von Heijne, Gunnar,, Ernst, Andreas M., Hacke, Moritz, Björkholm, Patrik,, Bruegger, Britta, Wieland, Felix   +5 more
core   +1 more source

Protein-Sphingolipid Interactions within Cellular Membranes [PDF]

, 2007
Each intracellular organelle critically depends on maintaining its specific lipid composition that in turn contributes to the biophysical properties of the membrane.
Hanada, K., Sprong, H., Wieland, F.T., Membraan enzymologie, Felix T. Wieland, Haberkant, P., Kentaro Hanada, Thiele, C., Brügger, B., Contreras, F.-X., Oliver Schmitt, F.-Xabier Contreras, Christoph Thiele, Britta Brügger, Schmitt, O., Hein Sprong, Constanze Reinhard, Per Haberkant, Dep Scheikunde, Reinhard, C.   +19 more
core   +1 more source

Expression of the Three Alternative Forms of the Sphingolipid Activator Protein Precursor in Baby Hamster Kidney Cells and Functional Assays in a Cell Culture System [PDF]

, 1996
Sphingolipid activator proteins (SAPs) are non-enzymatic glycoproteins required for lysosomal degradation of various sphingolipids with short oligosaccharide chains by their respective exohydrolases.
Sandhoff, Konrad, Klein, Andreas, Henseler, Margarete, Glombitza, Gereon J., Suziki, Kunihiko   +4 more
core   +1 more source

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

, 2012
Mitochondria are functionally and physically associated with heterotypic membranes, yet little is known about how these interactions impact mitochondrial outer-membrane permeabilization (MOMP) and apoptosis.
Kuwana, Tomomi, Chipuk, Jerry E., Obeid, Lina M., Bharti, Archana, Clarke, Christopher J., MCSTAY, Gavin, Siskind, Leah J., Green, Douglas R.   +7 more
core   +2 more sources

The Trypanosoma brucei sphingolipid synthase, an essential enzyme and a drug target [PDF]

, 2009
Sphingolipids are important structural components of eukaryotic membranes, in addition they and their precursors are involved in signal transduction processes.
Pan, Ssu-Ying
core  

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b [PDF]

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch, Kraiczy Peter, Böhm Sascha, van den Elsen Jean, Koch Tina K., Skerka Christine, Reuter Michael, Zipfel Peter F., Barthel Diana   +25 more
core   +1 more source

Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs. [PDF]

, 2014
Sphingolipids are essential components in eukaryotes and have various cellular functions. Recent developments in genome-editing technologies have facilitated gene disruption in various organisms and cell lines.
Toshiyuki Yamaji, Hanada Kentaro, Toshiyuki Yamaji (484487), Kentaro Hanada, Yamaji Toshiyuki, Kentaro Hanada (207598)   +5 more
core   +1 more source