Results 41 to 50 of about 1,761,902 (161)

Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]

, 2012
Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Prem Kumar, Sutherland K Maciver, Manuel Salto-tellez, Celestial T. Yap (142210), Tochhawng, L., Zhuo, J., Celestial T Yap, Maciver, S.K., Koh, Shiuan, K. Maciver, Salto-Tellez Manuel, Manikandan Jayapal (64624), Tan, Ee Hong, Hooi, S., Jayapal, Manikandan, Maciver, Sutherland K., Yaw Chyn Lim (142208), Zhuo Jingli, Lalchhandami Tochhawng (142188), Jingli Zhuo, Ee Hong Tan (142182), Ee Hong Tan, Alan Prem Kumar (142201), Tay Hwee Kee, Lim, Yaw Chyn, Tay, H., Kumar, A.P., Tochhawng, Lalchhandami, Alan Prem Kumar, Maciver, Sutherland K, Ami Tochhawng, Koh, S., Salto-Tellez, M., Hwee Kee Tay (64625), Tay, H.K., Maciver, S., Benedict Yan (142185), Yap Celestial T., Kumar, Alan Prem, Shiuan Koh (142191), Lalchhandami Tochhawng, Lim, Y., Shing Chuan Hooi (50996), Jayapal Manikandan, Goh, Yaw Chong, Shiuan Koh, Tan, E.H., Yap, C., Yap, Celestial T, Yap, Celestial T., Tochhawng Lalchhandami, Tan, E., Lim, Y.C., Hooi, Shing Chuan, An Jayapal, Yan, B., Hwee Kee Tay, Hooi, S.C., Kumar Alan Prem, Sutherland K. Maciver (142194), Tan Ee Hong, Celestial T. Yap, Goh, Y., Manikandan Jayapal, Maciver Sutherland K., Goh Yaw Chong, Jingli Zhuo (142178), Zhuo, Jingli, Yap, C.T., Benedict Yan, Lim Yaw Chyn, Yan, Benedict, Jayapal, M., Yaw Chyn Lim, Goh, Y.C., Salto-Tellez, Manuel, Yaw Chong Goh, Yaw Chong Goh (142205), Koh Shiuan, Yan Benedict, Hooi Shing Chuan, Manuel Salto-Tellez (142198), Tay, Hwee Kee, Shing Chuan Hooi   +83 more
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Identification of a Novel Sequence Involved in Lysosomal Sorting of the Sphingolipid Activator Protein Prosaposin [PDF]

Journal of Biological Chemistry, 2000
Prosaposin is synthesized as a 53-kDa protein, post-translationally modified to a 65-kDa form and further glycosylated to a 70-kDa secretory product. The 65-kDa protein is associated to Golgi membranes and is targeted to lysosomes, where four smaller nonenzymatic saposins implicated in the hydrolysis of sphingolipids are generated by its partial ...
Q, Zhao, C R, Morales
openaire   +2 more sources

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain [PDF]

, 2012
Functioning and processing of membrane proteins critically depend on the way their transmembrane segments are embedded in the membrane. Sphingolipids are structural components of membranes and can also act as intracellular second messengers.
Brügger, Britta, Ernst, Andreas M., Arne Elofsson, Andreas M. Ernst, Patrik Björkholm, Başak Gönen, Christoph Thiele, Britta Brügger, Thiele, Christoph, Rainer Pepperkok, von Heijne, Gunnar,, Gönen, Basak, Elofsson, Arne,, Per Haberkant, Wieland, Felix, Erik Lindahl, Contreras, F.-Xabier, Christian Tischer, Björkholm, Patrik, von Heijne, Gunnar, Tischer, Christian, Haberkant, Per, Elofsson, Arne, Lindahl, Erik, Felix Wieland, F.-Xabier Contreras, Pepperkok, Rainer, Björkholm, Patrik,, Gunnar von Heijne, Ernst, Andreas M,, Pepperkok, Rainer,, Thiele, Christoph,, Tischer, Christian,, Wieland, Felix,, Contreras, F.-Xabier,, Lindahl, Erik,, Brügger, Britta,, Haberkant, Per,   +37 more
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GPI anchoring leads to sphingolipid-dependent retention of endocytosed proteins in the recycling endosomal compartment

, 2001
Glycosylphosphatidylinositol (GPI) anchoring is important for the function of several proteins in the context of their membrane trafficking pathways. We have shown previously that endocytosed GPI-anchored proteins (GPI-APs) are recycled to the plasma ...
Chatterjee, Samit, Mayor, Satyajit, Hanada, Kentaro, Stevens, Victoria L., Smith, Elizabeth R.   +4 more
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Sphingolipid biosynthesis in man and microbes [PDF]

, 2018
Sphingolipids are essential molecules that, despite their long history, are still stimulating interest today. The reasons for this are that, as well as playing structural roles within cell membranes, they have also been shown to perform a myriad of cell ...
Campopiano, Dominic J., Peter J. Harrison, Dominic J. Campopiano, Dunn, Teresa m., Harrison, Peter J., Teresa M. Dunn   +5 more
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Sphingolipid-enriched membrane domains from rat cerebellar granule cells differentiated in culture - A compositional study

, 2000
Sphingolipid-enriched membrane domains, characterized by a particular protein and lipid composition, have been detected in a variety of cells. However, limited data are available concerning these domains in neuronal cells.
Alessandro Prinetti, Sandro Sonnino, Vanna Chigorno, V. Chigorno, G. Tettamanti, S. Sonnino, A. Prinetti, Guido Tettamanti   +7 more
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Abnormal islet sphingolipid metabolism in type 1 diabetes [PDF]

, 2018
AIMS/HYPOTHESIS: Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures.
K Dahl-Jørgensen (20885705), LA Claessens (21881309), BPC Koeleman (10456634), KF Hanssen (21833252), NG Morgan (21853058), CE Mathews (21853043), IC Gerling (21853040), MA Russell (13951002), BO Roep (21881312), F Pociot (13308969), L Krogvold (21833219), K Buschard (21881315), S Kaur (9895766), LJ Holm (21881303), JP Hasselby (21881306)   +14 more
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Sphingolipid management by an orchestra of lipid transfer proteins [PDF]

, 2008
The various membranes in eukaryotic cells have unique lipid compositions. Despite important discoveries in lipid research over recent decades, the basic principles by which cells define their membrane compositions are essentially unknown.
Neumann, S., van Meer, G., Membraan enzymologie, Dep Scheikunde   +3 more
core  

TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis [PDF]

, 2013
The evolutionarily conserved Orm1 and Orm2 proteins mediate sphingolipid homeostasis. However, the homologous Orm proteins and the signaling pathways modulating their phosphorylation and function are incompletely characterized.
Oppliger, Wolfgang, Hall, Michael N, Moes, Suzette, Shimobayashi, Mitsugu, Jenö, Paul, Hall, Michael N., Hall MN, Moes S, Oppliger W, Jenö P, Shimobayashi M   +10 more
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Molecular Basis of Genetic Sphingolipid Activator Protein Deficiencies.

Trends in Glycoscience and Glycotechnology, 1994
通常はリソソーム内に局在している一連の比較的小さな糖タンパク質が、短い親水性の先端基をもったスフィンゴ糖脂質の生理的分解の補助因子として機能する。GM2活性化因子タンパク質の遺伝子欠損では、テイサックス病の古典的幼児型と本質的に区別できない臨床上および生化学上の表現型になる。ヒトの第5染色体上にあるある単一遺伝子がGM2活性化因子タンパク質をコードする。2つの相同タンパク質sap-Bおよびsap-Cの遺伝子欠損は、それぞれ異染性白質萎縮症およびゴーシェ病と似ている障害を引き起こす。さらに2つの推定上の活性化因子タンパク質sap-A、sap-Dも、in vitro でいくつかのスフィンゴ脂質の分解を活性化することが知られている。しかしながら、in vivo のsap-A、sap ...
openaire   +2 more sources