Results 81 to 90 of about 10,663 (235)
The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological preconditioning [PDF]
, 2006 Includes bibliographical references (leaves 150-177).Ischemic preconditioning is a protective mechanism whereby repetitive transient ischaemia confer protection against the subsequent prolonged lethal ischaemia that is observed during myocardial ...
Suleman, Naushaad
core
The p21-activated kinase 1 (Pak1) signalling pathway in cardiac disease:from mechanistic study to therapeutic exploration [PDF]
, 2017 p21-activated kinase 1 (Pak1) is a member of the highly conserved family of serine/threonine protein kinases regulated by Ras-related small G-proteins, Cdc42/Rac1. It has been previously demonstrated to be involved in cardiac protection.
Wang, X +21 more
core +2 more sources
Health Care Science, EarlyView.This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying +6 more
wiley +1 more source
The mechanism of signal transduction by the GPI anchored Prod 1 protein [PDF]
, 2010 Salamanders such as the red spotted newt Notophthalamus viridescens and the axolotl Ambystoma mexicanum regenerate a number of anatomical structures following injury.
Blassberg, R.A.
core
The relevance of the storage of subunit c of ATP synthase in different forms and models of Batten disease (NCLs) [PDF]
, 2015 The discoveries of specific protein storage in the NCLs, particularly of subunit c of ATP synthase in most, and the sphingolipid activator proteins, SAPs or saposins A and D in CLN1, CLN10 and an unassigned form are reviewed.
Palmer, DN, Palmer, David N.
core +1 more source
Interdisciplinary Medicine, EarlyView.Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu +6 more
wiley +1 more source
Irrigation and Drainage, EarlyView.ABSTRACT Climate change is making water availability more uncertain, with growing consequences for the productivity and long‐term sustainability of tropical and subtropical fruit orchards. Mangifera indica L. and Persea americana Mill. both require large amounts of water to sustain growth and productivity.
Eleonora Cataldo
wiley +1 more source
Molecular Basis of Genetic Sphingolipid Activator Protein Deficiencies.
Trends in Glycoscience and Glycotechnology, 1994 通常はリソソーム内に局在している一連の比較的小さな糖タンパク質が、短い親水性の先端基をもったスフィンゴ糖脂質の生理的分解の補助因子として機能する。GM2活性化因子タンパク質の遺伝子欠損では、テイサックス病の古典的幼児型と本質的に区別できない臨床上および生化学上の表現型になる。ヒトの第5染色体上にあるある単一遺伝子がGM2活性化因子タンパク質をコードする。2つの相同タンパク質sap-Bおよびsap-Cの遺伝子欠損は、それぞれ異染性白質萎縮症およびゴーシェ病と似ている障害を引き起こす。さらに2つの推定上の活性化因子タンパク質sap-A、sap-Dも、in vitro でいくつかのスフィンゴ脂質の分解を活性化することが知られている。しかしながら、in vivo のsap-A、sap ...
openaire +2 more sources
Journal of the Science of Food and Agriculture, EarlyView.Abstract BACKGROUND Preventing chronic liver damage is essential for maintaining overall health and reducing the risk of serious liver diseases. Acetaminophen (APAP) overdose can lead to severe liver damage due to oxidative stress, and citrus fruits are rich in bioactive compounds that may have health benefits.
Po‐Yao Tsai +7 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu +4 more
wiley +1 more source