Neurobiology of Disease, 2017 Saposin deficiency is a childhood neurodegenerative lysosomal storage disorder (LSD) that can cause premature death within three months of life.
Samantha J. Hindle +4 more
doaj +1 more source
Frontiers in Genetics, 2019 Neuronal Ceroid Lipofuscinoses (NCLs) are progressive degenerative diseases mainly affect brain and retina. They are characterized by accumulation of autofluorescent storage material, mitochondrial ATPase subunit C, or sphingolipid activator proteins A ...
Xiao-Tun Ren +8 more
doaj +1 more source
Transcriptional profiling of the model organism "A. gossypii" : comparison of life cycle stages and transcription factor deletions [PDF]
, 2007 Experiments described in this PhD thesis used for the rst time custom-made oligonucleotide chips to substantially increase our knowledge and understanding of the model organism A. gossypii. Four sets of experiments of different scales were performed:
Rischatsch, Riccarda
core +1 more source
Regulation of Mitogen-Activated Protein Kinases by Sphingolipid Products in Oligodendrocytes [PDF]
The Journal of Neuroscience, 1999 Sphingolipid products such as ceramide (cer), sphingosine (sph), and sphingosine-1-phosphate (SPP) are implicated in the regulation of cell growth and apoptosis. We have recently shown that cer, sph, and SPP differentially modulate ionic events in cultured oligodendrocytes (OLGs).
H, Hida +3 more
openaire +2 more sources
From FIC to BID : target identification and functional characterization of "Bartonella" effector proteins [PDF]
, 2014 Pathogens belonging to the genus Bartonella employ a unique stealth infection strategy that involves evasion from the host immune system, replication in the endothelium and persistence in erythrocytes.
Pieles, Kathrin
core +1 more source
CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation [PDF]
Autophagy, 2018 The macroautophagy/autophagy and inflammasome pathways are linked through their roles in innate immunity and chronic inflammatory disease. Ceramide-1-phosphate (C1P) is a bioactive sphingolipid that regulates pro-inflammatory eicosanoid production. Whether C1P also regulates autophagy and inflammasome assembly/activation is not known. Here we show that
Shrawan Kumar Mishra +5 more
openaire +3 more sources
Expression of the Three Alternative Forms of the Sphingolipid Activator Protein Precursor in Baby Hamster Kidney Cells and Functional Assays in a Cell Culture System [PDF]
, 1996 Sphingolipid activator proteins (SAPs) are non-enzymatic glycoproteins required for lysosomal degradation of various sphingolipids with short oligosaccharide chains by their respective exohydrolases.
Sandhoff, Konrad +4 more
core +2 more sources
Do Sphingolipids Control Viral Membrane Protein Activity? [PDF]
Biophysical Journal, 2011 The membrane-behaviour of the matrix (M) protein from respiratory syncytical virus, a prototypical enveloped virus, has been characterised by surface techniques (tensiometry, Brewster angle microscopy and atomic force microscopy) and experiments using lipid bilayers (FRET, light microscopy).
Sanderson, John M. +3 more
openaire +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Sphingolipid metabolism dysfunctions [PDF]
, 2018 Sfingolipidi su glavne komponente staničnih membrana u živčanom sustavu svih eukariota. S obzirom da su uklopljeni u stanične membrane, oni kontroliraju i bitne stanične signalne puteve.
Hefer, Marija
core +3 more sources