Results 191 to 200 of about 51,484 (237)
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Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases
Chemistry and Physics of Lipids, 2016Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing number of physiologic and pathophysiologic processes that include cell cycle, apoptosis, angiogenesis, stress and inflammatory responses. Sphingomyelin is an important structural component of biological membranes, and one of the end-points in the synthesis of ...
Mohamad, Adada +2 more
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Molecular packing in sphingomyelin bilayers and sphingomyelin/phospholid mixtures
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2003The molecular packing properties of sphingomyelin (SM) from egg yolk were studied. The influence of the spontaneous curvature of SM on the phase behaviour of SM/dodecane/water systems was investigated. A comparison was made to a previous study by Lindblom et al. (Liq. Cryst. 3 (1988) 783), of the phase behaviour of dipalmitoylphosphatidylcholine (DPPC)/
Tomas, Byström, Göran, Lindblom
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Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001Tissue injury in inflammation involves the release of several cytokines that activate sphingomyelinases and generate ceramide. In the lung, the impaired metabolism of surfactant phosphatidylcholine (PC) accompanies this acute and chronic injury. These effects are long-lived and extend beyond the time frame over which tumor necrosis factor (TNF)-α and ...
J, Vivekananda, D, Smith, R J, King
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Interbilayer interactions between sphingomyelin and sphingomyelin/cholesterol bilayers
Biochemistry, 1992Pressure versus fluid spacing relations have been obtained for sphingomyelin bilayers in the gel phase and equimolar sphingomyelin/cholesterol in the liquid-crystalline phase by the use of X-ray diffraction analysis of osmotically stressed aqueous dispersions and oriented multilayers.
T J, McIntosh +3 more
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Nature, 1965
AN investigation of marine phospholipids in this laboratory necessitated the determination of Sphingomyelin. Sphingomyelin is frequently estimated by determining sphingosine according to the method of McKibbin and Taylor1. This method consists of the separation of sphingosine from other nitrogenous bases by extraction from an aqueous acid solution with
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AN investigation of marine phospholipids in this laboratory necessitated the determination of Sphingomyelin. Sphingomyelin is frequently estimated by determining sphingosine according to the method of McKibbin and Taylor1. This method consists of the separation of sphingosine from other nitrogenous bases by extraction from an aqueous acid solution with
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Interaction of glucagon with sphingomyelins
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1982Abstract In the presence of either egg or bovine brain sphingomyelin, the spectral properties of glucagon undergo changes which are similar to those which occur in the presence of synthetic phosphatidylcholines. The fluorescence emission spectra are blue shifted about 10 nm in the presence of lipid and the peptide acquires an increased helical ...
R M, Epand, L T, Boni, S W, Hui
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THE ISOLATION OF BEEF SPHINGOMYELINS
Canadian Journal of Biochemistry, 1964A method was developed for the quantitative isolation of tissue sphingomyelins. Total lipid extracts of tissues were subjected to selective hydrolysis to destroy ester phosphatides and plasmalogens. The water-soluble hydrolysis products were removed by solvent fractionation.
W A, SPENCER, R, SCHAFFRIN
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Regulation of sphingomyelin metabolism
Pharmacological Reports, 2016Sphingolipids (SFs) represent a large class of lipids playing diverse functions in a vast number of physiological and pathological processes. Sphingomyelin (SM) is the most abundant SF in the cell, with ubiquitous distribution within mammalian tissues, and particularly high levels in the Central Nervous System (CNS).
Kamil Bienias +4 more
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Biochemistry, 1997
In this study, we examine the phase behavior as well as lateral diffusion and percolation in the region of coexisting gel and fluid phases in binary mixtures composed of dimyristoylphosphatidylcholine and one of two totally synthetic D-erythro-sphingomyelins (having either C16 or C24 acyl chains, both having similar gel to liquid-crystalline phase ...
L K, Bar, Y, Barenholz, T E, Thompson
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In this study, we examine the phase behavior as well as lateral diffusion and percolation in the region of coexisting gel and fluid phases in binary mixtures composed of dimyristoylphosphatidylcholine and one of two totally synthetic D-erythro-sphingomyelins (having either C16 or C24 acyl chains, both having similar gel to liquid-crystalline phase ...
L K, Bar, Y, Barenholz, T E, Thompson
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Biological functions of sphingomyelins
Progress in Lipid Research, 2013Sphingomyelin (SM) is a dominant sphingolipid in membranes of mammalian cells and this lipid class is specifically enriched in the plasma membrane, the endocytic recycling compartment, and the trans Golgi network. The distribution of SM and cholesterol among cellular compartments correlate.
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