Results 1 to 10 of about 7,161 (190)

Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. [PDF]

J Clin Invest, 2021
Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, the role of intestinal FXR in atherosclerosis and its potential as a target for clinical treatment have not been explored.
Wu Q, Sun L, Hu X, Wang X, Xu F, Chen B, Liang X, Xia J, Wang P, Aibara D, Zhang S, Zeng G, Yun C, Yan Y, Zhu Y, Bustin M, Zhang S, Gonzalez FJ, Jiang C.   +18 more
europepmc   +6 more sources

Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. [PDF]

J Biol Chem, 2014
Cholesterol-loaded foam cell macrophages are prominent in atherosclerotic lesions and play complex roles in both inflammatory signaling and lipid metabolism, which are underpinned by large scale reprogramming of gene expression. We performed a microarray study of primary human macrophages that showed that transcription of the sphingomyelin ...
Traini M, Quinn CM, Sandoval C, Johansson E, Schroder K, Kockx M, Meikle PJ, Jessup W, Kritharides L.   +8 more
europepmc   +7 more sources

Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B. [PDF]

Cancer Sci, 2020
AbstractHepatocellular carcinoma (HCC) is the most common type of liver cancer. It has a poor prognosis because it is often diagnosed at the advanced stage when treatments are limited. In addition, HCC pathogenesis is not fully understood, and this has affected early diagnosis and treatment of this disease.
Liu B, Xiao J, Dong M, Qiu Z, Jin J.
europepmc   +6 more sources

Activation of Sphingomyelin Phosphodiesterase 3 in Liver Regeneration Impedes the Progression of Colorectal Cancer Liver Metastasis Via Exosome-Bound Intercellular Transfer of CeramidesSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: The machinery that prevents colorectal cancer liver metastasis (CRLM) in the context of liver regeneration (LR) remains elusive. Ceramide (CER) is a potent anti-cancer lipid involved in intercellular interaction.
Qingping Li, Jieyuan Li, Kai Wang, Leyi Liao, Yiyi Li, Hanbiao Liang, Can Huang, Jian Gan, Xiaoyu Dong, Yaowen Hu, Jiaxin Cheng, Hongli Ji, Cuiting Liu, Minghui Zeng, Sheng Yu, Biao Wang, Jianping Qian, Zhongshun Tang, Yonghong Peng, Shanhua Tang, Mengxuan Li, Jie Zhou, Jun Yan, Chuanjiang Li   +23 more
doaj   +4 more sources

Sphingomyelin phosphodiesterase acid like 3B (SMPDL3b) regulates Perilipin5 (PLIN5) expression and mediates lipid droplet formation [PDF]

Genes and Diseases, 2022
Shamroop Kumar Mallela, Mengyuan Ge, Judith Molina, Javier Varona Santos, Jin-Ju Kim, Alla Mitrofanova, Hassan Al-Ali, Brian Marples, Sandra Merscher, Alessia Fornoni   +9 more
doaj   +4 more sources

Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis). [PDF]

J Insect Sci, 2018
Sphingomyelin phosphodiesterase (SMPD) is a hydrolase that plays a major role in metabolic reactions involving sphingomyelin. Here, we describe an analysis of the cDNA sequence and gene structure of SMPD in bumblebee (Bombus lantschouensis). The expression of SMPD in different tissues and at different developmental stages and reproductive statuses was ...
Han L, Ding G, Liu Y, Huang J, Wu J.
europepmc   +3 more sources

A novel estrogen receptor 1: sphingomyelin phosphodiesterase acid-like 3B pathway mediates rituximab response in myositis patients. [PDF]

Rheumatology (Oxford), 2023
Abstract Objectives The B-cell depleting biologic, rituximab, is used to treat refractory autoimmune myositis. However, the beneficial effects of rituximab appear to outweigh the known contribution of B cells in myositis. We aimed to elucidate how myositis patients respond differently to rituximab and
Parkes JE, Boehler JF, Li N, Kendra RM, O'Hanlon TP, Hoffman EP, Peterson JM, Miller FW, Rider LG, Nagaraju K.   +9 more
europepmc   +3 more sources

Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription. [PDF]

Virol Sin
• SMPD3 is identified as a novel host factor that inhibits Hepatitis B virus (HBV) replication at the transcriptional level. • SMPD3 knockdown enhances HBV replication in various cell models, increasing levels of HBsAg, HBeAg, and HBV DNA. • Mechanistic studies reveal SMPD3's inhibition of HBV transcription without affecting RNA stability or promoter ...
Li C, Zhou M, Zhao K, Liu W, Zhu C, Cheng X, Xia Y.   +6 more
europepmc   +3 more sources

Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3. [PDF]

Oncol Rep, 2015
A recent study demonstrated that intracellular small/microRNAs are released from cells, and some of these extracellular RNAs are embedded in vesicles, such as ceramide-rich exosomes, on lipid-bilayer membranes. In the present study, we examined the effects of sphingomyelin phosphodiesterase 3 (SMPD3), which generates ceramide from sphingomyelin, on the
Kubota S, Chiba M, Watanabe M, Sakamoto M, Watanabe N.   +4 more
europepmc   +4 more sources

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response. [PDF]

Oncotarget, 2020
Neutral sphingomyelinase 2 (nSMase2), the product of the sphingomyelin phosphodiesterase 3 (SMPD3) gene, catalyzes the hydrolysis of sphingomyelin to ceramide. Ceramide acts on various signaling pathways to influence cell proliferation, survival, and stress response.
Jabalee J, Towle R, Lawson J, Dickman C, Garnis C.   +4 more
europepmc   +4 more sources