Results 1 to 10 of about 4,601 (147)

Sphingomyelin phosphodiesterase acid like 3B (SMPDL3b) regulates Perilipin5 (PLIN5) expression and mediates lipid droplet formation [PDF]

Genes and Diseases, 2022
Alla Mitrofanova, Patricia Wahl, Jinju Kim   +2 more
exaly   +6 more sources

Activation of Sphingomyelin Phosphodiesterase 3 in Liver Regeneration Impedes the Progression of Colorectal Cancer Liver Metastasis Via Exosome-Bound Intercellular Transfer of CeramidesSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: The machinery that prevents colorectal cancer liver metastasis (CRLM) in the context of liver regeneration (LR) remains elusive. Ceramide (CER) is a potent anti-cancer lipid involved in intercellular interaction.
Qingping Li, Jieyuan Li, Kai Wang, Leyi Liao, Yiyi Li, Hanbiao Liang, Can Huang, Jian Gan, Xiaoyu Dong, Yaowen Hu, Jiaxin Cheng, Hongli Ji, Cuiting Liu, Minghui Zeng, Sheng Yu, Biao Wang, Jianping Qian, Zhongshun Tang, Yonghong Peng, Shanhua Tang, Mengxuan Li, Jie Zhou, Jun Yan, Chuanjiang Li   +23 more
doaj   +4 more sources

Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid‐like 3B [PDF]

Cancer Science, 2020
AbstractHepatocellular carcinoma (HCC) is the most common type of liver cancer. It has a poor prognosis because it is often diagnosed at the advanced stage when treatments are limited. In addition, HCC pathogenesis is not fully understood, and this has affected early diagnosis and treatment of this disease.
Junfei Jin
exaly   +5 more sources

Evolutionary diversity of sphingolipid metabolism proteins in fungi [PDF]

IMA Fungus
Fungi are adapted to survive across environments with fluctuating oxygen availability. Transition to terrestrial and parasitic lifestyles required remodeling of the cell membrane, including sphingolipid composition. Ceramides occupy a central position in
Magdalena Płecha, Blanka Sokołowska, Drishtee Barua, Julia Bartczak, Maria Sobczyk, Dagmara Koperska, Anna Kułakowska, Adam Komosa, Anna Muszewska   +8 more
doaj   +4 more sources

Upregulation of sphingomyelin and ABCA8 in response to TDP-43 pathology in amyotrophic lateral sclerosis brain. [PDF]

Brain Pathol
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Isik FI, Pickford R, Dzamko N, Rye KA, Kim WS.   +4 more
europepmc   +2 more sources

Clinical Characteristics of 19 Patients With Acid Sphingomyelinase Deficiency: A Case Series From Multiple Centers in Argentina

JIMD Reports
Acid sphingomyelinase deficiency (ASMD), historically known as Niemann‐Pick disease, is a rare and potentially fatal lysosomal storage disease caused by pathogenic variants in the sphingomyelin phosphodiesterase 1 (SMPD1) gene, which encodes acid ...
Maria Cristina Robin, Consuelo Durand, Guillermo Guelbert, Norberto Guelbert, Mariana Leguizamon, Mariana Nuñez Miñana, Maria Alejandra Cédola, Maria Gabriela deLourdes Pacheco, Evangelina Gonzalez, Marisa Spallina, Sandra Quijano   +10 more
doaj   +2 more sources

A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations. [PDF]

J Neurochem
The uncinate fasciculus (UF), which serves to connect the anterior temporal lobe and the orbitofrontal cortex, is a highly understudied white matter fiber bundle. In this study, we characterized the fatty acid (FA) profile of myelin phospholipids in a fraction‐specific manner, as well as the cholesterol concentrations, in the human postmortem UF.
Perlman K, Chen CT, Smith ME, Kim J, Turecki G, Bazinet RP, Mechawar N.   +6 more
europepmc   +2 more sources

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science
Spontaneous ovarian hyperstimulation syndrome (OHSS) is closely associated with follicle stimulating hormone receptor (FSHR) functional mutations. We observed that estrildid finches naturally carry the gain‐of‐function FSHR p.Thr449Ala mutation found in ...
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
doaj   +2 more sources

Genomic Correlates of Disease Recovery in Natural Populations of the Sierra Nevada Yellow-Legged Frog (Rana sierrae). [PDF]

Mol Ecol
ABSTRACT In our rapidly changing world, evolution is likely to play an important role in facilitating the resilience of wildlife populations. The Sierra Nevada yellow‐legged frog (Rana sierrae) provides a rare example of recovery following severe declines caused by the amphibian chytrid fungus (Batrachochytrium dendrobatidis).
Byrne AQ, Rothstein AP, Knapp RA, Rosenblum EB.   +3 more
europepmc   +2 more sources

Targeting SMPDL3B to Ameliorate Radiation- and Cisplatin-Induced Renal Toxicity [PDF]

Cells
Kidney toxicity remains a major dose-limiting complication of radiation therapy and platinum-based chemotherapy, yet the molecular determinants of renal susceptibility and resilience to these genotoxic treatments are incompletely understood.
Anis Ahmad, Shamroop Kumar Mallela, Saba Ansari, Mohammed Alnukhali, Sandra Merscher, Alla Mitrofanova, Youssef H. Zeidan, Alan Pollack, Alessia Fornoni, Brian Marples   +9 more
doaj   +2 more sources