Sphingomyelin Phosphodiesterase Acid-like 3A (SMPDL3A) Is a Novel Nucleotide Phosphodiesterase Regulated by Cholesterol in Human Macrophages* [PDF]
Journal of Biological Chemistry, 2014 Cholesterol-loaded foam cell macrophages are prominent in atherosclerotic lesions and play complex roles in both inflammatory signaling and lipid metabolism, which are underpinned by large scale reprogramming of gene expression. We performed a microarray study of primary human macrophages that showed that transcription of the sphingomyelin ...
Leonard Kritharides +2 more
exaly +10 more sources
Clinical Characteristics of 19 Patients With Acid Sphingomyelinase Deficiency: A Case Series From Multiple Centers in Argentina [PDF]
JIMD ReportsAcid sphingomyelinase deficiency (ASMD), historically known as Niemann‐Pick disease, is a rare and potentially fatal lysosomal storage disease caused by pathogenic variants in the sphingomyelin phosphodiesterase 1 (SMPD1) gene, which encodes acid ...
Maria Cristina Robin +10 more
doaj +3 more sources
Activation of Sphingomyelin Phosphodiesterase 3 in Liver Regeneration Impedes the Progression of Colorectal Cancer Liver Metastasis Via Exosome-Bound Intercellular Transfer of CeramidesSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: The machinery that prevents colorectal cancer liver metastasis (CRLM) in the context of liver regeneration (LR) remains elusive. Ceramide (CER) is a potent anti-cancer lipid involved in intercellular interaction.
Qingping Li +23 more
doaj +4 more sources
Sphingomyelin phosphodiesterase acid like 3B (SMPDL3b) regulates Perilipin5 (PLIN5) expression and mediates lipid droplet formation [PDF]
Genes and Diseases, 2022 Shamroop Kumar Mallela +9 more
doaj +4 more sources
Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism [PDF]
Cell MetabolismMetabolic-dysfunction-associated steatohepatitis (MASH) remains a major health challenge. Herein, we identify sphingomyelin phosphodiesterase 3 (SMPD3) as a key driver of hepatic ceramide accumulation through increasing sphingomyelin hydrolysis at the cell membrane.
Kanglong Wang, Yutang Cao, Yingquan Wen
exaly +5 more sources
Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis). [PDF]
Journal of Insect Science, 2018 Sphingomyelin phosphodiesterase (SMPD) is a hydrolase that plays a major role in metabolic reactions involving sphingomyelin. Here, we describe an analysis of the cDNA sequence and gene structure of SMPD in bumblebee (Bombus lantschouensis). The expression of SMPD in different tissues and at different developmental stages and reproductive statuses was ...
Jiaxing Huang, Yanjie Liu, Guiling Ding
exaly +4 more sources
Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B [PDF]
Cancer Science, 2020 AbstractHepatocellular carcinoma (HCC) is the most common type of liver cancer. It has a poor prognosis because it is often diagnosed at the advanced stage when treatments are limited. In addition, HCC pathogenesis is not fully understood, and this has affected early diagnosis and treatment of this disease.
Junfei Jin
exaly +5 more sources
Contribution of sphingomyelin phosphodiesterase acid-like 3B to the proliferation, migration, and invasion of ovarian cancer cells [PDF]
Translational Cancer ResearchCancer has the highest mortality rate among gynecological cancers and poses a serious threat to women's lives. However, the treatment options for ovarian cancer are still limited, and exploring effective targeted biomarkers is particularly important for predicting and treating ovarian cancer.
Baozhi Song
exaly +4 more sources
Evolutionary diversity of sphingolipid metabolism proteins in fungi [PDF]
IMA FungusFungi are adapted to survive across environments with fluctuating oxygen availability. Transition to terrestrial and parasitic lifestyles required remodeling of the cell membrane, including sphingolipid composition. Ceramides occupy a central position in
Magdalena Płecha +8 more
doaj +4 more sources
Sph-mediated mtDNA release and autophagy-dependent ferroptosis contribute to Staphylococcus aureus-induced mastitis. [PDF]
PLoS PathogensStaphylococcus aureus (S. aureus), a major pathogen of mastitis, employs a diverse arsenal of virulence factors to invade and disrupt mammary tissues, thereby eliciting a complex and dysregulated inflammatory response.
Yunfei Wei +11 more
doaj +2 more sources