SMPD3 as a Potential Biomarker and Therapeutic Target in Hepatocellular Carcinoma [PDF]
International Journal of GenomicsConclusions: SMPD3 plays a protective role in HCC by inhibiting tumor growth and progression. Its high expression is associated with better survival outcomes and may serve as a promising prognostic marker and potential therapeutic target in HCC.
Dan Zhu, Lei Cao
exaly +6 more sources
Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis [PDF]
Journal of Extracellular BiologyExtracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing off‐target effects and ...
Tino Hochepied +2 more
exaly +7 more sources
A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes [PDF]
International Journal of Oral ScienceBlood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes (T2DM). Strategies to safely and efficiently improve the bone regeneration disorder caused by blood glucose fluctuation are still a challenge.
Lingxiao Wang +2 more
exaly +6 more sources
Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background Gastric carcinoma (GC) is a fatal disease. Detection of new biomarkers that can be utilized in the early diagnosis of GC is a pressing need.
Marwa Sayed Abdel-Tawab
exaly +4 more sources
The nSMase2/Smpd3 gene modulates the severity of muscular dystrophy and the emotional stress response in mdx mice [PDF]
BMC Medicine, 2020 Background Duchenne muscular dystrophy (DMD) is a progressive, degenerative muscular disorder and cognitive dysfunction caused by mutations in the dystrophin gene.
Takayoshi Inoue +2 more
exaly +6 more sources
DNA methylation of SMPD3-based diagnostic biomarkers of NASH and mild fibrosis
Genes and Diseases, 2023 Non-alcoholic fatty liver disease (NAFLD) is a liver condition that is widely prevalent across the world. A considerable number of people with NAFLD have the potential to progress to a more severe form of the condition known as nonalcoholic ...
Na Wu +12 more
doaj +4 more sources
Scientific Reports, 2023 Fenretinide is a synthetic retinoid that can prevent obesity and improve insulin sensitivity in mice by directly altering retinol/retinoic acid homeostasis and inhibiting excess ceramide biosynthesis.
Dawn Thompson +9 more
doaj +6 more sources
Exploring the Role of SMPD3 in the lncRNA-miRNA-mRNA Regulatory Network in TBI Progression by Influencing Energy Metabolism. [PDF]
J Inflamm ResBackground Traumatic brain injury (TBI) is associated with disturbances in energy metabolism. This study aimed to construct a lncRNA-miRNA-mRNA network through bioinformatics methods to explore energy metabolism-related genes in the pathogenesis of TBI ...
Cui C +6 more
europepmc +5 more sources
Therapeutic Application of Extracellular Vesicles-Capsulated Adeno-Associated Virus Vector via nSMase2/Smpd3, Satellite, and Immune Cells in Duchenne Muscular Dystrophy [PDF]
International Journal of Molecular Sciences, 2022 Duchenne muscular dystrophy (DMD) is caused by loss-of-function mutations in the dystrophin gene on chromosome Xp21. Disruption of the dystrophin–glycoprotein complex (DGC) on the cell membrane causes cytosolic Ca2+ influx, resulting in protease ...
Takashi Okada +2 more
exaly +4 more sources
Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits [PDF]
Nature CommunicationsExtracellular vesicles (EVs) are nano-sized, membrane-delimited, particles released by cells that carry signaling macromolecules. A major pathway of EV production is potentiated by neutral sphingomyelinase 2 (SMPD3/nSMAse2), an enzyme that generates ...
Clair Crewe +17 more
doaj +2 more sources