SMPD3 as a Potential Biomarker and Therapeutic Target in Hepatocellular Carcinoma [PDF]
International Journal of GenomicsConclusions: SMPD3 plays a protective role in HCC by inhibiting tumor growth and progression. Its high expression is associated with better survival outcomes and may serve as a promising prognostic marker and potential therapeutic target in HCC.
Dan Zhu, Lei Cao
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Challenging the conventional wisdom: Re-evaluating Smpd3's role in extracellular vesicle biogenesis [PDF]
Journal of Extracellular BiologyExtracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing offâtarget effects and ...
Tino Hochepied +2 more
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Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background Gastric carcinoma (GC) is a fatal disease. Detection of new biomarkers that can be utilized in the early diagnosis of GC is a pressing need.
Marwa S Abdel-Tawab
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A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes [PDF]
International Journal of Oral ScienceBlood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes (T2DM). Strategies to safely and efficiently improve the bone regeneration disorder caused by blood glucose fluctuation are still a challenge.
Zhipeng Fan, Yilin He
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Inflammation related proteins and PLCG1 may contribute to papillary thyroid carcinoma risk through a potential regulatory axis [PDF]
Discover OncologyBackground Papillary thyroid carcinoma (PTC) is usually indolent, but a subset of patients shows aggressive behavior. Understanding protein-level mechanisms is essential for identifying new therapeutic targets. Materials and methods We integrated protein
Shi-Qi Wang +4 more
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Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits [PDF]
Nature CommunicationsExtracellular vesicles (EVs) are nano-sized, membrane-delimited, particles released by cells that carry signaling macromolecules. A major pathway of EV production is potentiated by neutral sphingomyelinase 2 (SMPD3/nSMAse2), an enzyme that generates ...
Clair Crewe +17 more
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Deep chemical structure graph learning deciphers the lipotoxicity code of hypertriglyceridemic pancreatitis [PDF]
npj Digital MedicineThe discrepancy between serum triglyceride levels and the clinical severity of hyperlipidemic acute pancreatitis (HLAP) complicates risk stratification. Traditional lipidomics, which primarily rely on linear abundance, often fail to distinguish the HLAP ...
Anliang Huang +12 more
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Choroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles [PDF]
Fluids and Barriers of the CNSThe choroid plexus (CP) in the brain ventricles secretes cerebrospinal fluid (CSF) that bathes the adjacent subventricular zone (SVZ). As the largest adult neurogenic region enriched with neural stem/progenitor cells (NSPCs), the SVZ supplies newborn ...
Luke L. Liu +2 more
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BMC Medicine, 2020 Background Duchenne muscular dystrophy (DMD) is a progressive, degenerative muscular disorder and cognitive dysfunction caused by mutations in the dystrophin gene.
Takayoshi Inoue +2 more
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Metabolic reprogramming promotes apoptosis resistance in acute lymphoblastic leukemia through CASP3 lactylation [PDF]
Molecular CancerAcute lymphoblastic leukemia (ALL) is characterized by metabolic adaptations that support rapid cell proliferation and resistance to apoptosis. Our study identifies elevated sphingomyelin (SM) as a key metabolic alteration in ALL, contributing to ...
Zhi Lin +7 more
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