SMPD3 expression is spatially regulated in the developing embryo by SOXE factors. [PDF]
Dev Biol, 2023 During epithelial-to-mesenchymal transition (EMT), significant rearrangements occur in plasma membrane protein and lipid content that are important for membrane function and acquisition of cell motility.
Piacentino ML +4 more
europepmc +5 more sources
Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons [PDF]
Emerging Microbes and Infections, 2019 The harmful effects of ZIKA virus (ZIKV) infection are reflected by severe neurological manifestations such as microcephaly in neonates and other complications associated with Guillain-Barré syndrome in adults.
Wenshuo Zhou +4 more
doaj +5 more sources
SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment [PDF]
Cell Death and Disease, 2018 Neutral sphingomyelinase smpd3 is most abundantly expressed in neurons of brain. The function of SMPD3 has remained elusive. Here, we report a pathogenetic nexus between absence of SMPD3 in the Golgi compartment (GC) of neurons of the smpd3-/- mouse ...
Susanne Brodesser, Erika Binczek
exaly +5 more sources
Upregulation of smpd3 via BMP2 stimulation and Runx2
BMB Reports, 2009 Deletion of smpd3 induces osteogenesis and dentinogenesis imperfecta in mice. smpd3 is highly elevated in the parietal bones of developing mouse calvaria, but not in sutural mesenchymes.
Hyun-Mo Ryoo, Jae Mok Lee, Je-Yoel Cho
exaly +5 more sources
Neutral Sphingomyelinase 2 (SMPD3) Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization [PDF]
American Journal of Pathology, 2019 SMPD3 deficiency in the neutral sphingomyelinase (Smpd3-/-) mouse results in a novel form of juvenile dwarfism, suggesting smpd3 as polygenetic determinant of body-height.
Anja Niehoff
exaly +4 more sources
Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition [PDF]
Cell Death and Disease, 2016 Systemic loss of neutral sphingomyelinase (SMPD3) in mice leads to a novel form of systemic, juvenile hypoplasia (dwarfism). SMPD3 deficiency in mainly two growth regulating cell types contributes to the phenotype, in chondrocytes of skeletal growth ...
Susanne Brodesser +2 more
exaly +4 more sources
Transcriptomics analysis reveals potential regulatory role of nSMase2 (Smpd3) in nervous system development and function of middle-aged mouse brains. [PDF]
Genes Brain BehavNeutral sphingomyelinase‐2 (nSMase2), gene name sphingomyelin phosphodiesterase‐3 (Smpd3), is a key regulatory enzyme responsible for generating the sphingolipid ceramide. The function of nSMase2 in the brain is still controversial.
Zhu Z, McClintock TS, Bieberich E.
europepmc +4 more sources
Neutral Sphingomyelinase (SMPD3) Deficiency Causes a Novel Form of Chondrodysplasia and Dwarfism That Is Rescued by Col2A1-Driven smpd3 Transgene Expression [PDF]
American Journal of Pathology, 2007 Neutral sphingomyelinase SMPD3 (nSMase2), a sphingomyelin phosphodiesterase, resides in the Golgi apparatus and is ubiquitously expressed. Gene ablation of smpd3 causes a generalized prolongation of the cell cycle that leads to late embryonic and juvenile hypoplasia because of the SMPD3 deficiency in hypothalamic neurosecretory neurons.
Anja Niehoff +2 more
exaly +4 more sources
Beni-Suef University Journal of Basic and Applied Sciences, 2023 Marwa Sayed Abdel-Tawab +7 more
doaj +3 more sources
SMPD3 suppresses IDH mutant tumor growth via dual autocrine-paracrine roles [PDF]
Proceedings of the National Academy of Sciences, 2020 Isocitrate dehydrogenase (IDH) mutant gliomas, including oligodendroglioma (IDH-O) and astrocytoma (IDH-A), have signature slow-growth rates that are poorly understood.
Anjali Balakrishnan +24 more
semanticscholar +8 more sources