Results 11 to 20 of about 1,842 (145)

Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons [PDF]

Emerging Microbes and Infections, 2019
The harmful effects of ZIKA virus (ZIKV) infection are reflected by severe neurological manifestations such as microcephaly in neonates and other complications associated with Guillain-Barré syndrome in adults.
Girish Neelakanta, Wenshuo Zhou, Michael B Sherman   +2 more
exaly   +4 more sources

Beyond type 2 asthma biomarkers: risk stratification for NSAID-exacerbated respiratory disease [PDF]

ERJ Open Research
Introduction Type 2 (T2) asthma is often associated with chronic rhinosinusitis with nasal polyposis (CRSwNP). Additionally, nonsteroidal anti-inflammatory drug (NSAID) intolerance leads to NSAID-exacerbated respiratory disease (N-ERD).
Jacqueline Pérez-Pazos, Asunción García-Sánchez, Miguel Estravís, Emma Moreno-Jimenez, Natalia Morgado, Manuel Gómez-García, Jacinto Ramos-González, María Gil-Melcón, Cristina Martín-García, Francisco Muñoz-Bellido, Catalina Sanz, María Isidoro-García, Ignacio Dávila   +12 more
doaj   +4 more sources

Holy Basil (Ocimum sanctum L.) Flower and Fenofibrate Improve Lipid Profiles in Rats with Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD): The Role of Choline Metabolism [PDF]

Plants
Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to choline metabolism. The present study investigated the effect of holy basil (Ocimum sanctum L.) flower water extract (OSLY) on MASLD with choline metabolism as an underlying ...
Siraphat Taesuwan, Jakkapong Inchai, Konpong Boonyingsathit, Chanika Chimkerd, Kunchit Judprasong, Pornchai Rachtanapun, Chatchai Muanprasat, Chutima S. Vaddhanaphuti   +7 more
doaj   +3 more sources

Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels [PDF]

Cell Reports, 2020
Summary: Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines.
Jian Shi, Adam J. Hyman, Dario De Vecchis, Jiehan Chong, Laeticia Lichtenstein, T. Simon Futers, Myriam Rouahi, Anne Negre Salvayre, Nathalie Auge, Antreas C. Kalli, David J. Beech   +10 more
doaj   +2 more sources

Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice [PDF]

Frontiers in Molecular Neuroscience
IntroductionRisperidone is a widely used antipsychotic that reduces psychotic symptoms through modulation of monoaminergic signaling. At the cellular level, however, its effects extend beyond receptor antagonism and induce spatially discrete ...
Magdalena Ziemiańska, Mateusz Zięba, Anna Radlicka-Borysewska, Łukasz Szumiec, Sławomir Gołda, Małgorzata Borczyk, Marcin Piechota, Michał Korostyński, Jan Rodriguez Parkitna   +8 more
doaj   +2 more sources

The Ceramide-Dependent EV Secretome Differentially Affects Prostate Cancer Cell Migration [PDF]

Cells
Tumor-derived extracellular vesicles (EVs) play an important role in cancer progression. Neutral sphingomyelinases (nSMases) are lipid-modifying enzymes that modulate the secretion of EVs from cells.
Dolma Choezom, Jan-Moritz Plum, Pradhipa Karuna M., Adi Danieli-Mackay, Christof Lenz, Phillipp Brockmeyer, Julia Christina Gross   +6 more
doaj   +2 more sources

Impact of Neutral Sphingomyelinase Inhibition on Small Extracellular Vesicle Production by Mural Granulosa Cells and In Vitro Folliculogenesis in Mice. [PDF]

Mol Reprod Dev
ABSTRACT Small extracellular vesicles (sEVs) function as critical regulators of ovarian follicular development. Although several pathways, including one involving neutral sphingomyelinase (nSMase), contribute to sEV production, the specific pathway active in ovarian follicles has not been clearly identified.
Matsushita K, Matsuno Y, Kita K, Ichikawa A, Maruyama N, Fujii W, Endo T, Sugiura K.   +7 more
europepmc   +2 more sources

Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue

Lipids in Health and Disease, 2012
Background Inflammation and increased ceramide concentrations characterise adipose tissue of obese women with high liver fat content compared to equally obese women with normal liver fat content.
Kolak Maria, Gertow Joanna, Westerbacka Jukka, Summers Scott A, Liska Jan, Franco-Cereceda Anders, Orešič Matej, Yki-Järvinen Hannele, Eriksson Per, Fisher Rachel M   +9 more
doaj   +2 more sources

Rare genetic variants involved in increased risk of paroxysmal atrial fibrillation in a Japanese population [PDF]

Scientific Reports
Atrial fibrillation (AF) is the most prevalent arrhythmia in the world and can cause serious complications such as stroke or heart failure. Paroxysmal atrial fibrillation (PAF), a subtype of AF, accounts for approximately 25% of AF cases and is estimated
Kanji Tabata, Takeaki Sudo, Yuki Nagata, Kensuke Ihara, Ken Asada, Atsuhiro Kinoshita, Yasuaki Tanaka, Yasuteru Yamauchi, Takeshi Sasaki, Hitoshi Hachiya, Yasushi Imai, Hideo Fujita, Tetsuo Sasano, Tetsushi Furukawa, Takanori Iwata, Toshihiro Tanaka   +15 more
doaj   +2 more sources

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia [PDF]

Neurobiology of Disease
Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson   +12 more
doaj   +2 more sources