Results 31 to 40 of about 1,881 (140)

Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice [PDF]

Frontiers in Molecular Neuroscience
IntroductionRisperidone is a widely used antipsychotic that reduces psychotic symptoms through modulation of monoaminergic signaling. At the cellular level, however, its effects extend beyond receptor antagonism and induce spatially discrete ...
Magdalena Ziemiańska, Mateusz Zięba, Anna Radlicka-Borysewska, Łukasz Szumiec, Sławomir Gołda, Małgorzata Borczyk, Marcin Piechota, Michał Korostyński, Jan Rodriguez Parkitna   +8 more
doaj   +2 more sources

Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice

Journal of Advanced Research
Graphical ...
Shengjie Li, Aoxiang Zhuge, Hui Chen, Shengyi Han, Jian Shen, Kaicen Wang, Jiafeng Xia, He Xia, Shiman Jiang, Youhe Wu, Lanjuan Li   +10 more
semanticscholar   +3 more sources

Holy Basil (Ocimum sanctum L.) Flower and Fenofibrate Improve Lipid Profiles in Rats with Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD): The Role of Choline Metabolism [PDF]

Plants
Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to choline metabolism. The present study investigated the effect of holy basil (Ocimum sanctum L.) flower water extract (OSLY) on MASLD with choline metabolism as an underlying ...
Siraphat Taesuwan, Jakkapong Inchai, Konpong Boonyingsathit, Chanika Chimkerd, Kunchit Judprasong, Pornchai Rachtanapun, Chatchai Muanprasat, Chutima S. Vaddhanaphuti   +7 more
doaj   +2 more sources

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity. [PDF]

Adv Sci (Weinh)
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
Beech DJ.
europepmc   +2 more sources

3D Model of Human Epidermis Exposed to Staphylococci Reveals Keratinocyte Responses Unique to Atopy-Associated S. aureus Challenge. [PDF]

Allergy
Allergy, Volume 80, Issue 8, Page 2388-2391, August 2025.
Brzoza P, Camacho M, Tyshchenko M, Morytko A, Kwitniewski M, Pastuszczak M, Stepinska P, Migaczewski M, Cichy J.   +8 more
europepmc   +2 more sources

Effect of Procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3[S]

Journal of Lipid Research, 2014
In hepatocytes, aging-associated decline in GSH has been linked to activation of neutral SMase (nSMase), accumulation of bioactive ceramide, and inflammation. In this study, we seek to test whether dietary supplementation with the cysteine precursor, L-2-
Gergana Deevska, Manjula Sunkara, Claudia Karakashian, Benjamin Peppers, Andrew J. Morris, Mariana N. Nikolova-Karakashian   +5 more
doaj   +2 more sources

Rare genetic variants involved in increased risk of paroxysmal atrial fibrillation in a Japanese population [PDF]

Scientific Reports
Atrial fibrillation (AF) is the most prevalent arrhythmia in the world and can cause serious complications such as stroke or heart failure. Paroxysmal atrial fibrillation (PAF), a subtype of AF, accounts for approximately 25% of AF cases and is estimated
Kanji Tabata, Takeaki Sudo, Yuki Nagata, Kensuke Ihara, Ken Asada, Atsuhiro Kinoshita, Yasuaki Tanaka, Yasuteru Yamauchi, Takeshi Sasaki, Hitoshi Hachiya, Yasushi Imai, Hideo Fujita, Tetsuo Sasano, Tetsushi Furukawa, Takanori Iwata, Toshihiro Tanaka   +15 more
doaj   +2 more sources

High Dose C6 Ceramide-Induced Response in Embryonic Hippocampal Cells [PDF]

Biomolecules
Ceramide is a critical molecule in both the physiology and pathology of the central nervous system. The most studied aspect is its effect on embryonic/stem cells. A salient question is whether low doses of ceramide induce neuronal differentiation without
Federico Fiorani, Martina Mandarano, Samuela Cataldi, Alessandra Mirarchi, Stefano Bruscoli, Francesco Ragonese, Bernard Fioretti, Toshihide Kobayashi, Nario Tomishige, Tommaso Beccari, Claudia Floridi, Cataldo Arcuri, Elisabetta Albi   +12 more
doaj   +2 more sources

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia [PDF]

Neurobiology of Disease
Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson   +12 more
doaj   +2 more sources

SMPD3 wt Allele [PDF]

Definitions, 2020

semanticscholar   +2 more sources