Pharmacokinetic Evaluation of Neutral Sphinghomyelinase2 (nSMase2) Inhibitor Prodrugs in Mice and Dogs [PDF]
PharmaceuticsBackground: Extracellular vesicles (EVs) can carry pathological cargo, contributing to disease progression. The enzyme neutral sphingomyelinase 2 (nSMase2) plays a critical role in EV biogenesis, making it a promising therapeutic target.
Barbara S Slusher +2 more
exaly +7 more sources
Dynamic changes in the proximitome of neutral sphingomyelinase-2 (nSMase2) in TNFα stimulated Jurkat cells [PDF]
Frontiers in ImmunologyCeramides generated by the activity of the neutral sphingomyelinase 2 (nSMase2) play a pivotal role in stress responses in mammalian cells. Dysregulation of sphingolipid metabolism has been implicated in numerous inflammation-related pathologies. However,
Marie Schöl +11 more
doaj +7 more sources
Translational Neurodegeneration, 2023 Background Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is triggered by ceramide
Barbara S Slusher +2 more
exaly +5 more sources
Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons
Neurobiology of Disease, 2023 Extracellular vesicles (EVs) have been proposed to regulate the deposition of Aβ. Multiple publications have shown that APP, amyloid processing enzymes and Aβ peptides are associated with EVs.
Norman J Haughey +2 more
exaly +5 more sources
Lipid droplets and small extracellular vesicles interplay in Japanese encephalitis virus non-lytic release [PDF]
mBioLipid droplets (LDs) and small extracellular vesicles (sEVs) are classically known for lipid metabolism and intercellular communication, respectively.
Bhaghyasree Mallick +7 more
doaj +2 more sources
ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation[S]
Journal of Lipid Research, 2016 Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional ...
Christopher J Clarke, Yusuf A. Hannun
exaly +3 more sources
Phenotypic modulation of corpus cavernosum smooth muscle cells in type 2 diabetic rats is mediated by regulated exosomes secretion via neutral sphingomyelinase-2 [PDF]
Asian Journal of AndrologyPhenotypic modulation of corpus cavernosum smooth muscle cells (CCSMCs) is closely related to the occurrence of erectile dysfunction (ED). However, the effect of exosomes (EXOs) on the phenotypic modulation of CCSMCs with diabetes mellitus (DM)-related ...
Feng-Zhi Chen +6 more
doaj +2 more sources
The steady-state level of plasma membrane ceramide is regulated by neutral sphingomyelinase 2 [PDF]
Journal of Lipid ResearchDuring the last 30 years, an increasing number of cellular functions have been reported to be regulated by the lipid ceramide. The diversity in the ceramide structure, leading to tens of ceramide species and the discrete distribution based on subcellular
Anne G. Ostermeyer-Fay +6 more
doaj +2 more sources
Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling [PDF]
Journal of Extracellular BiologyExtra‐large extracellular vesicles (XLEVs), with diameters > 600 nm, are increasingly recognised as mediators of specialized modes of intercellular communication; however, the molecular mechanisms governing their biogenesis and functional regulation ...
Shuo Wang +3 more
doaj +2 more sources
Docosahexaenoic acid remodels lipid composition of lipid rafts and mitochondrial function in ApoE4/4 mouse brain: a multi-omic investigation [PDF]
Molecular BiomedicineAlzheimer’s disease (AD) is an irreversible neurodegenerative disorder lacking curative therapies, with ApoE4 as the strongest genetic risk factor driving lipid dyshomeostasis and neuronal damage in the central nervous system.
Yu Liu +10 more
doaj +2 more sources