Results 1 to 10 of about 1,596 (140)

Dynamic changes in the proximitome of neutral sphingomyelinase-2 (nSMase2) in TNFα stimulated Jurkat cells [PDF]

Frontiers in Immunology
Ceramides generated by the activity of the neutral sphingomyelinase 2 (nSMase2) play a pivotal role in stress responses in mammalian cells. Dysregulation of sphingolipid metabolism has been implicated in numerous inflammation-related pathologies. However,
Christian Stigloher, Fabian Schumacher, Burkhard Kleuser   +2 more
exaly   +6 more sources

Pharmacokinetic Evaluation of Neutral Sphinghomyelinase2 (nSMase2) Inhibitor Prodrugs in Mice and Dogs [PDF]

Pharmaceutics
Background: Extracellular vesicles (EVs) can carry pathological cargo, contributing to disease progression. The enzyme neutral sphingomyelinase 2 (nSMase2) plays a critical role in EV biogenesis, making it a promising therapeutic target.
Barbara Stauch Slusher, Arindom Pal, Rana Rais   +2 more
exaly   +6 more sources

Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons

Neurobiology of Disease, 2023
Extracellular vesicles (EVs) have been proposed to regulate the deposition of Aβ. Multiple publications have shown that APP, amyloid processing enzymes and Aβ peptides are associated with EVs.
Norman Haughey, Pragney Deme, Barbara Stauch Slusher   +2 more
exaly   +5 more sources

Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia [PDF]

Frontiers in Molecular Neuroscience, 2019
Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an influential role in the cell-to-cell spread of neurodegenerative diseases, including the intercellular transmission of α-synuclein (α-syn). However, the regulation of
Martin Hallbeck, Christopher Sackmann, Valerie Sackmann   +2 more
exaly   +7 more sources

Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling [PDF]

Journal of Extracellular Biology
Extra‐large extracellular vesicles (XLEVs), with diameters > 600 nm, are increasingly recognised as mediators of specialized modes of intercellular communication; however, the molecular mechanisms governing their biogenesis and functional regulation ...
Shuo Wang, Rio Imai, Yuya Kaneko, Yosuke Tanaka   +3 more
doaj   +3 more sources

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

Translational Neurodegeneration, 2023
Background Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is triggered by ceramide
Barbara Stauch Slusher, Benjamin Bell, Dimitrios Kapogiannis   +2 more
exaly   +4 more sources

Lipid droplets and small extracellular vesicles interplay in Japanese encephalitis virus non-lytic release [PDF]

mBio
Lipid droplets (LDs) and small extracellular vesicles (sEVs) are classically known for lipid metabolism and intercellular communication, respectively.
Bhaghyasree Mallick, Ananya Mondal, Ankita Sarkar, Tamoghna Chakraborty, Khadijah Khan, Dilip Kumar, Subhas Chandra Biswas, Sourish Ghosh   +7 more
doaj   +2 more sources

The steady-state level of plasma membrane ceramide is regulated by neutral sphingomyelinase 2 [PDF]

Journal of Lipid Research
During the last 30 years, an increasing number of cellular functions have been reported to be regulated by the lipid ceramide. The diversity in the ceramide structure, leading to tens of ceramide species and the discrete distribution based on subcellular
Anne G. Ostermeyer-Fay, Abhay Kanodia, Ranjana Pathak, Maria Jose Hernandez-Corbacho, Aarnoud C. van der Spoel, Yusuf A. Hannun, Daniel Canals   +6 more
doaj   +2 more sources

Ceramide‐mediated orchestration of oxidative stress response through filopodia‐derived small extracellular vesicles [PDF]

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H2O2 in Hela cells stimulated filopodia formation and the secretion of EVs.
Zainuddin Quadri, Ahmed Elsherbini, Simone M. Crivelli, Salim S. El‐Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D. Spassieva, Mariana Nikolova‐Karakashian, Erhard Bieberich   +10 more
doaj   +2 more sources

Research Progress of Exosome-Derived microRNA in Alcohol Use Disorders: A Critical Review. [PDF]

Addict Biol
Exosome‐derived microRNAs represent stable and mechanistically active mediators of alcohol‐induced multi‐organ injury. This review summarizes how chronic alcohol exposure reshapes exosomal miRNA cargo across the liver, immune system, and brain, highlighting key miRNAs with diagnostic value and therapeutic potential.
Zhang B, Xie TT, Ma Q, Jiang YP, Wang YM.   +4 more
europepmc   +2 more sources