The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling [PDF]
Frontiers in Immunology, 2018 By promoting ceramide release at the cytosolic membrane leaflet, the neutral sphingomyelinase 2 (NSM) is capable of organizing receptor and signalosome segregation. Its role in T cell receptor (TCR) signaling remained so far unknown. We now show that TCR-
Markus Sauer +2 more
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Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation [PDF]
Cells, 2023 Non-alcoholic fatty liver disease (NAFLD) is manifested by hepatic steatosis, insulin resistance, hepatocyte death, and systemic inflammation. Obesity induces steatosis and chronic inflammation in the liver.
Fatema Al-Rashed +15 more
doaj +4 more sources
The steady-state level of plasma membrane ceramide is regulated by neutral sphingomyelinase 2 [PDF]
Journal of Lipid ResearchDuring the last 30 years, an increasing number of cellular functions have been reported to be regulated by the lipid ceramide. The diversity in the ceramide structure, leading to tens of ceramide species and the discrete distribution based on subcellular
Anne G. Ostermeyer-Fay +6 more
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Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. [PDF]
PLoS ONE, 2015 Ceramide is a bioactive lipid that plays an important role in stress responses leading to apoptosis, cell growth arrest and differentiation. Ceramide production is due in part to sphingomyelin hydrolysis by sphingomyelinases.
Mariana Figuera-Losada +11 more
doaj +7 more sources
Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice [PDF]
Journal of Lipid Research, 2018 Sphingolipids are key signaling lipids in cancer. Genome-wide studies have identified neutral SMase-2 (nSMase2), an enzyme generating ceramide from SM, as a potential repressor for hepatocellular carcinoma.
Liansheng Zhong +13 more
doaj +4 more sources
Dynamic changes in the proximitome of neutral sphingomyelinase-2 (nSMase2) in TNFα stimulated Jurkat cells [PDF]
Frontiers in ImmunologyCeramides generated by the activity of the neutral sphingomyelinase 2 (nSMase2) play a pivotal role in stress responses in mammalian cells. Dysregulation of sphingolipid metabolism has been implicated in numerous inflammation-related pathologies. However,
Christian Stigloher +2 more
exaly +4 more sources
Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes [PDF]
Journal of Lipid Research, 2023 Obesity-associated diabetes is linked to the accumulation of ceramide in various organs, including the liver. The exact mechanisms by which ceramide contributes to diabetic pathology are unclear, but one proposed scenario is that ceramide accumulation ...
S. El-Amouri +3 more
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Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV [PDF]
Neurobiology of Disease, 2022 People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population.
Xiaolei Zhu +13 more
doaj +2 more sources
Targeting sphingolipid metabolism: inhibition of neutral sphingomyelinase 2 impairs coronaviral replication organelle formation [PDF]
mBioMany plus-strand RNA viruses, including coronaviruses, orchestrate the formation of specialized replication organelles in the cytoplasm of infected cells by specific membrane-associated viral nonstructural proteins (nsp’s).
Florian Salisch +5 more
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Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation [PDF]
Frontiers in Molecular Biosciences, 2020 Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane.
Maria Nathalia De Lira +4 more
doaj +2 more sources