Results 31 to 40 of about 8,477 (148)

A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization [PDF]

The Journal of Experimental Medicine, 2011
A deletion mutation called fro (fragilitas ossium) in the murine Smpd3 (sphingomyelin phosphodiesterase 3) gene leads to a severe skeletal dysplasia. Smpd3 encodes a neutral sphingomyelinase (nSMase2), which cleaves sphingomyelin to generate bioactive lipid metabolites.
Khavandgar, Zohreh, Poirier, Christophe, Clarke, Christopher J., Li, Jingjing, Wang, Nicholas, McKee, Marc D., Hannun, Yusuf A., Murshed, Monzur   +7 more
openaire   +2 more sources

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Molecular Brain, 2021
Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation.
Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys, Varghese John   +12 more
doaj   +1 more source

Neutral Sphingomyelinase 2 (nSMase2) Is a Phosphoprotein Regulated by Calcineurin (PP2B) [PDF]

Journal of Biological Chemistry, 2010
We previously reported that exposure of human airway epithelial cells to oxidative stress increased ceramide generation via specific activation of neutral sphingomyelinase2 (nSMase2). Here we show that nSMase2 is a phosphoprotein exclusively phosphorylated at serine residues.
Simone, Filosto, William, Fry, Anne A, Knowlton, Tzipora, Goldkorn   +3 more
openaire   +2 more sources

Impact of HepG2 Cells Glutathione Depletion on Neutral Sphingomyelinases mRNA Levels and Activity

Current Issues in Molecular Biology, 2023
Liver cancer is a prevalent form of cancer worldwide. While research has shown that increasing sphingomyelin (SM) hydrolysis by activating the cell surface membrane-associated neutral sphingomyelinase 2 (nSMase2) can control cell proliferation and ...
Marie Gamal, Hatem Tallima, Hassan M. E. Azzazy, Anwar Abdelnaser   +3 more
doaj   +1 more source

A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products

Journal of Lipid Research, 2006
Previous studies from our laboratory and others presented evidence that oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine (OxPAPC) and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine can inhibit ...
Kimberly A. Walton, Bogdan G. Gugiu, Miracle Thomas, Robert J. Basseri, Daniel R. Eliav, Robert G. Salomon, Judith A. Berliner   +6 more
doaj   +1 more source

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α. [PDF]

Sci Rep, 2020
ABSTRACT Obesity is associated with elevated levels of TNF-α and proinflammatory CD11c monocytes /macrophages. TNF-α mediated dysregulation in the plasticity of monocytes/macrophages is concomitant with pathogenesis of several inflammatory diseases, including metabolic syndrome, but the underlying mechanisms are ...
Al-Rashed F, Ahmad Z, Thomas R, Melhem M, Snider AJ, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R.   +8 more
europepmc   +5 more sources

Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells [PDF]

Biochemical Journal, 2011
Activation of N-SMase (neutral sphingomyelinase) is an established part of the response of cytokines such as TNF (tumour necrosis factor)-α. However, it remains unclear which of the currently cloned N-SMase isoforms (nSMase1, nSMase2 and nSMase3) are responsible for this activity.
Christopher J, Clarke, Emily A, Cloessner, Patrick L, Roddy, Yusuf A, Hannun   +3 more
openaire   +2 more sources

Inhibition of neutral sphingomyelinase-2 facilitates remyelination [PDF]

, 2019
Abstract For reasons that are not completely understood, remyelination is often incomplete, producing thin myelin sheaths with disorganized structure. We investigated the cellular basis for this altered myelin structure, and found that the response of oligodendrocyte progenitor cells (OPCs), and mature ...
Yoo, Seung-Wan, Agarwal, Amit, Smith, Matthew D., Khuder, Saja S., Baxi, Emily G., Thomas, Ajit G., Rojas, Camilo, Moniruzzman, Mohammed, Slusher, Barbara S., Bergles, Dwight E., Calabresi, Peter A., Haughey, Norman J.   +11 more
openaire   +1 more source

Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. [PDF]

PLoS ONE, 2010
BACKGROUND:Sphingomyelin hydrolysis in response to stress-inducing agents, and subsequent ceramide generation, are implicated in various cellular responses, including apoptosis, inflammation and proliferation, depending on the nature of the different ...
Raphael Devillard, Sylvain Galvani, Jean-Claude Thiers, Jean-Louis Guenet, Yusuf Hannun, Jacek Bielawski, Anne Nègre-Salvayre, Robert Salvayre, Nathalie Augé   +8 more
doaj   +1 more source

Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells

Cells, 2019
Extracellular vesicles (EVs), including exosomes and microvesicles, function in cell-to-cell communication through delivery of proteins, lipids and microRNAs to target cells via endocytosis and membrane fusion.
Andrew Khayrullin, Priyanka Krishnan, Luis Martinez-Nater, Bharati Mendhe, Sadanand Fulzele, Yutao Liu, Julie A. Mattison, Mark W. Hamrick   +7 more
doaj   +1 more source