Results 51 to 60 of about 8,477 (148)

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin

Cellular Physiology and Biochemistry, 2018
Background/Aims: Mycobacteria-induced diseases, especially tuberculosis, cause more than 1 million deaths each year, which is higher than any other single bacterial pathogen.
Yuqing Wu, Cao Li, Andrea Riehle, Barbara Pollmeier, Erich Gulbins, Heike Grassmé   +5 more
doaj   +1 more source

Cytotoxicity Profiling of Tenacibaculum Extracellular Products on Chinook Salmon (Oncorhynchus tshawytscha) Gill Cell Line, OTgill1PFR

Journal of Fish Diseases, EarlyView.
ABSTRACT Tenacibaculosis is an important disease of marine fishes caused by bacteria of the genus Tenacibaculum. Pathogenic Tenacibaculum species or serotypes, including Tenacibaculum maritimum, T. dicentrarchi, T. finnmarkense and T. soleae, have been isolated from farmed Chinook salmon (Oncorhynchus tshawytscha) during disease outbreaks in Aotearoa ...
Bjorn Böhmert, Michael Algie, Karthiga Kumanan, Kate S. Hutson, Georgina C. Dowd   +4 more
wiley   +1 more source

Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
The activation of neutral sphingomyelinase-2 (nSMase2) and consequent ceramide production are implicated in many stress-induced signaling pathways. Trafficking of nSMase2 from the Golgi compartment to the plasma membrane (PM) in response to signaling stimuli has been described. However, the precise mechanisms of transport remain unknown.
Delphine, Milhas, Christopher J, Clarke, Jolanta, Idkowiak-Baldys, Daniel, Canals, Yusuf A, Hannun   +4 more
openaire   +2 more sources

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

Nature Communications, 2023
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of caveolin-1 tyrosine-14 (Cav-1Y14) and ceramide generation in caveolae ...
V. S. Peche, T. A. Pietka, M. Jacome-Sosa, D. Samovski, H. Palacios, G. Chatterjee-Basu, A. C. Dudley, W. Beatty, G. A. Meyer, I. J. Goldberg, N. A. Abumrad   +10 more
doaj   +1 more source

The Pathogenic Sphingolipid Psychosine is Secreted in Extracellular Vesicles in the Brain of a Mouse Model of Krabbe Disease

ASN Neuro, 2022
Psychosine exerts most of its toxic effects by altering membrane dynamics with increased shedding of extracellular vesicles (EVs). In this study, we discovered that a fraction of psychosine produced in the brain of the Twitcher mouse, a model for Krabbe ...
Cory R. Reiter, Rima Rebiai, Angelika Kwak, Jeff Marshall, Dylan Wozniak, Giusepe Scesa, Duc Nguyen, Emily Rue, Koralege C. Pathmasiri, Robert Pijewski, Richard van Breemen, Stephanie Cologna, Stephen J. Crocker, M Irene Givogri, Ernesto R Bongarzone   +14 more
doaj   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source

Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease

JCI Insight, 2021
IL-33 is a key mediator of chronic airway disease driven by type 2 immune pathways, yet the nonclassical secretory mechanism for this cytokine remains undefined.
Ella Katz-Kiriakos, Deborah F. Steinberg, Colin E. Kluender, Omar A. Osorio, Catie Newsom-Stewart, Arjun Baronia, Derek E. Byers, Michael J. Holtzman, Dawn Katafiasz, Kristina L. Bailey, Steven L. Brody, Mark J. Miller, Jennifer Alexander-Brett   +12 more
doaj   +1 more source

Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA₂β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes

Molecules, 2021
Type 1 diabetes (T1D) development, in part, is due to ER stress-induced β-cell apoptosis. Activation of the Ca2+-independent phospholipase A2 beta (iPLA2β) leads to the generation of pro-inflammatory eicosanoids, which contribute to β-cell death and T1D.
Tomader Ali, Xiaoyong Lei, Suzanne E. Barbour, Akio Koizumi, Charles E. Chalfant, Sasanka Ramanadham   +5 more
doaj   +1 more source

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang, Xin Fu, Jingchao Bai, Yanguo Liu, Kai Huang   +4 more
wiley   +1 more source