Results 51 to 60 of about 25,021,772 (171)

Neutral sphingomyelinase 2 ( smpd3 ) in the control of postnatal growth and development [PDF]

Proceedings of the National Academy of Sciences, 2005
Neutral sphingomyelinases sphingomyelin phosphodiesterase (SMPD)2 and -3 hydrolyze sphingomyelin to phosphocholine and ceramide. smpd2 is expressed ubiquitously, and smpd3 is expressed predominantly in neurons of the CNS.
Wilhelm, Stoffel, Britta, Jenke, Barbara, Blöck, Markus, Zumbansen, Jürgen, Koebke   +4 more
openaire   +2 more sources

Identification of Heat Shock Protein 60 as a Regulator of Neutral Sphingomyelinase 2 and Its Role in Dopamine Uptake. [PDF]

PLoS ONE, 2013
Activation of sphingomyelinase (SMase) by extracellular stimuli is the major pathway for cellular production of ceramide, a bioactive lipid mediator acting through sphingomyelin (SM) hydrolysis.
Kyong-Hoon Ahn, Seok-Kyun Kim, Jong-Min Choi, Sung-Yun Jung, Jong-Hoon Won, Moon-Jung Back, Zhicheng Fu, Ji-Min Jang, Hae-Chan Ha, Dae-Kyong Kim   +9 more
doaj   +1 more source

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

Neurobiology of Disease
Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson   +12 more
doaj   +1 more source

Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells [PDF]

, 2017
Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the ...
Carmen Mecca, Albi E., Ambesi-Impiombato, Francesco Saverio, Samuela Cataldi, Elisabetta Albi, Fioretti, Bernard, Hunot, Stéphane, Légeron, François-Pierre, Hunot, Stéphane, Traina G, Cataldi, Samuela, Fioretti B, Traina, Giovanna, Lazzarini, Andrea, Francesco Saverio Ambesi-Impiombato, Hunot S, Mercedes Garcia-Gil, Anna Tasegian, Légeron, François-Pierre, Michela Codini, Tommaso Beccari, Arcuri C, Stéphane Hunot, Mecca C, Codini, Michela, Lazzarini A, Codini M, Curcio F, Garcia-Gil M, Albi, Elisabetta, Beccari T, Garcia-Gil, Mercedes, Légeron FP, Ambesi-Impiombato FS, Tasegian, Anna, Curcio, Francesco, Cataldi S, Beccari, Tommaso, François-Pierre Légeron, Francesco Curcio, Tasegian A, Arcuri, Cataldo, Bernard Fioretti, Giovanna Traina, Cataldo Arcuri, Andrea Lazzarini, Mecca, Carmen   +46 more
core   +1 more source

Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL

Redox Biology, 2015
The neutral type 2 sphingomyelinase (nSMase2) hydrolyzes sphingomyelin and generates ceramide, a major bioactive sphingolipid mediator, involved in growth arrest and apoptosis.
Sandra Garoby-Salom, Myriam Rouahi, Elodie Mucher, Nathalie Auge, Robert Salvayre, Anne Negre-Salvayre   +5 more
doaj   +1 more source

Gene expression of ceramide metabolism enzymes in fat depots of different localization in cardiovascular diseases

Российский кардиологический журнал, 2023
Aim. To assess gene expression of enzymes of the sphingomyelinase pathway of ceramide biosynthesis and degradation in fat depots of various localization in patients with cardiovascular diseases.Material and methods.
O. V. Gruzdeva, E. V. Belik, Yu. A. Dyleva, E. G. Uchasova, A. V. Ponasenko, A. G. Kutikhin, V. E. Markova, E. E. Gorbatovskaya, E. V. Fanaskova, S. V. Ivanov, A. N. Stasev, M. G. Zinets, T. A. Slesareva, O. L. Barbarash   +13 more
doaj   +1 more source

The CD40-ligand stimulates T-lymphocytes via the neutral sphingomyelinase : A novel function of the CD40-ligand as signalling molecule [PDF]

, 1997
Recent results suggest an activation of T-lymphocytes via the CD40L implying a dual function of this ligand involved in the activation of both B- and T-lymphocytes [1–4].
Lang, F., Koppenhoefer, U., Gulbins, E., Brenner, B.   +3 more
core   +1 more source

Partial purification and properties of acid sphingomyelinase from rat liver.

Journal of Lipid Research, 1983
Acid sphingomyelinase was purified approximately 5,200-fold from the mitochondria-lysosome-enriched particles of rat liver by sequential chromatography on DEAE-cellulose, octyl-Sepharose, Sephacryl S-300, Concanavalin A-Sepharose, and CM-cellulose.
K Watanabe, N Sakuragawa, M Arima, E Satoyoshi   +3 more
doaj   +1 more source

Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869. [PDF]

Cell Discov, 2018
Zika virus (ZIKV) is a neurotrophic flavivirus that is capable of infecting humans, leading to brain abnormalities during fetal development. The ZIKV infectivity in neural target cells remains poorly understood.
Huang Y, Li Y, Zhang H, Zhao R, Jing R, Xu Y, He M, Peer J, Kim YC, Luo J, Tong Z, Zheng J.   +11 more
europepmc   +2 more sources

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source