Results 61 to 70 of about 25,021,772 (171)

Sphingolipid and ceramide homeostasis : potential therapeutic targets [PDF]

, 2012
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction.
Smith, Terry, Simon A. Young, Denny, Paul, Young, Simon, Denny, Paul W., Mina, J.G., Mina, John, Denny, P.W., Smith, Terry K., Mina, John G., John G. Mina, Young, S.A., Smith, T.K., Paul W. Denny, Young, Simon A., Terry K. Smith   +15 more
core   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin

Cellular Physiology and Biochemistry, 2018
Background/Aims: Mycobacteria-induced diseases, especially tuberculosis, cause more than 1 million deaths each year, which is higher than any other single bacterial pathogen.
Yuqing Wu, Cao Li, Andrea Riehle, Barbara Pollmeier, Erich Gulbins, Heike Grassmé   +5 more
doaj   +1 more source

Mechanisms of Arachidonic Acid In Vitro Tumoricidal Impact

Molecules, 2023
To promote the potential of arachidonic acid (ARA) for cancer prevention and management, experiments were implemented to disclose the mechanisms of its tumoricidal action.
Hatem Tallima, Rashika El Ridi
doaj   +1 more source

Advances in Radiotherapy for Neoadjuvant Therapy of Stage III Non‐Small Cell Lung Cancer

Cancer Science, EarlyView.
This review summarizes three neoadjuvant radiotherapy techniques for stage III NSCLC, highlighting SFRT's low‐toxicity dual immune‐tumor control benefits and radioimmunotherapy's superior pathological response to guide precise multimodal treatment. ABSTRACT This review aims to systematically summarize the mechanisms of action, clinical evolution, and ...
Qinrong Mao, Yuanchun Yu, Yan Fang, Shaofeng Zhu, Chengjin Tang, Jing Cai   +5 more
wiley   +1 more source

Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
The activation of neutral sphingomyelinase-2 (nSMase2) and consequent ceramide production are implicated in many stress-induced signaling pathways. Trafficking of nSMase2 from the Golgi compartment to the plasma membrane (PM) in response to signaling stimuli has been described. However, the precise mechanisms of transport remain unknown.
Delphine, Milhas, Christopher J, Clarke, Jolanta, Idkowiak-Baldys, Daniel, Canals, Yusuf A, Hannun   +4 more
openaire   +2 more sources

Cytotoxicity Profiling of Tenacibaculum Extracellular Products on Chinook Salmon (Oncorhynchus tshawytscha) Gill Cell Line, OTgill1PFR

Journal of Fish Diseases, EarlyView.
ABSTRACT Tenacibaculosis is an important disease of marine fishes caused by bacteria of the genus Tenacibaculum. Pathogenic Tenacibaculum species or serotypes, including Tenacibaculum maritimum, T. dicentrarchi, T. finnmarkense and T. soleae, have been isolated from farmed Chinook salmon (Oncorhynchus tshawytscha) during disease outbreaks in Aotearoa ...
Bjorn Böhmert, Michael Algie, Karthiga Kumanan, Kate S. Hutson, Georgina C. Dowd   +4 more
wiley   +1 more source

A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody.

, 2011
International audienceBACKGROUND: Outcomes for organ transplantation are constantly improving because of advances in organ preservation, surgical techniques, immune clinical monitoring, and immunosuppressive treatment preventing acute transplant ...
Nathalie Augé, Denis Calise, Jean-Claude Thiers, Hans-Willi Krell, Augé, Nathalie, Salvayre, Robert, Magali Trayssac, Rostaing, Lionel, Anne Nègre-Salvayre, Nassim Kamar, Sylvain Galvani, Federico Sallusto, Kamar, Nassim, Mogens Thomsen, Trayssac, Magali, Calise, Denis, Krell, Hans-Willi, Thomsen, Mogens, Robert Salvayre, Thiers, Jean-Claude, Galvani, Sylvain, Lionel Rostaing, Sallusto, Federico, Nègre-Salvayre, Anne   +23 more
core   +1 more source

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

Nature Communications, 2023
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of caveolin-1 tyrosine-14 (Cav-1Y14) and ceramide generation in caveolae ...
V. S. Peche, T. A. Pietka, M. Jacome-Sosa, D. Samovski, H. Palacios, G. Chatterjee-Basu, A. C. Dudley, W. Beatty, G. A. Meyer, I. J. Goldberg, N. A. Abumrad   +10 more
doaj   +1 more source

The Pathogenic Sphingolipid Psychosine is Secreted in Extracellular Vesicles in the Brain of a Mouse Model of Krabbe Disease

ASN Neuro, 2022
Psychosine exerts most of its toxic effects by altering membrane dynamics with increased shedding of extracellular vesicles (EVs). In this study, we discovered that a fraction of psychosine produced in the brain of the Twitcher mouse, a model for Krabbe ...
Cory R. Reiter, Rima Rebiai, Angelika Kwak, Jeff Marshall, Dylan Wozniak, Giusepe Scesa, Duc Nguyen, Emily Rue, Koralege C. Pathmasiri, Robert Pijewski, Richard van Breemen, Stephanie Cologna, Stephen J. Crocker, M Irene Givogri, Ernesto R Bongarzone   +14 more
doaj   +1 more source