Results 81 to 90 of about 8,477 (148)

The regulation of T cell metabolism by neutral sphingomyelinase 2

, 2020
T cells play an essential role in the immune system. Engaging the T cell receptor (TCR) initiates a cascade of signaling events that activates the T cells. Neutral sphingomyelinase (NSM) is a member of a superfamily of enzymes responsible for the hydrolysis of sphingomyelin into phosphocholine and ceramide.
openaire   +2 more sources

Platinum Nanoparticles Enhance Exosome Release in Human Lung Epithelial Adenocarcinoma Cancer Cells (A549): Oxidative Stress and the Ceramide Pathway are Key Players

International Journal of Nanomedicine, 2021
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, KoreaCorrespondence: Sangiliyandi Gurunathan; Jin-Hoi KimDepartment of Stem Cell and ...
Gurunathan S, Kang MH, Jeyaraj M, Kim JH
doaj  

Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide[S]

Journal of Lipid Research, 2010
Data from animal experiments strongly suggest that ceramide is an important mediator of lipotoxicity in the heart and that accumulation of ceramide contributes to cardiomyocyte apoptosis associated with type 2 diabetes and obesity.
Marcin Baranowski, Agnieszka Blachnio-Zabielska, Tomasz Hirnle, Dorota Harasiuk, Krzysztof Matlak, Malgorzata Knapp, Piotr Zabielski, Jan Gorski   +7 more
doaj   +1 more source

Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis

Journal of Extracellular Biology
Extracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing off‐target effects and ...
Marlies Burgelman, Pieter Dujardin, Anthony Willems, Tino Hochepied, Griet Van Imschoot, Elien Van Wonterghem, Lien Van Hoecke, Charysse Vandendriessche, Roosmarijn E. Vandenbroucke   +8 more
doaj   +1 more source

Lovastatin reversed the enhanced sphingomyelin caused by 27-hydroxycholesterol in cultured vascular endothelial cells

Biochemistry and Biophysics Reports, 2016
Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Qi Zhou, Allan Luo, Fred A Kummerow
doaj   +1 more source

Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells

BMC Complementary and Alternative Medicine, 2013
Abstract Background Some of ginsenosides, root extracts from Panax ginseng, exert cytotoxicity against cancer cells through disruption of membrane subdomains called lipid rafts. Protopanaxadiol (PPD) exhibits the highest cytotoxic effect among 8 ginsenosides which we evaluated for anti-cancer activity. We investigated
Park, Bonggoo, Lee, Yong-Moon, Kim, Jae-Sung, Her, Youl, Kang, Ju Hee, Oh, Seung-Hyun, Kim, Hwan-Mook   +6 more
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ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation[S]

Journal of Lipid Research, 2016
Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional ...
Christopher J. Clarke, Achraf A. Shamseddine, Joseph J. Jacob, Gabrielle Khalife, Tara A. Burns, Yusuf A. Hannun   +5 more
doaj   +1 more source

In silico analysis of neutral sphingomyelinase 2

, 2020
177
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Ceramide‐mediated orchestration of oxidative stress response through filopodia‐derived small extracellular vesicles

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H2O2 in Hela cells stimulated filopodia formation and the secretion of EVs.
Zainuddin Quadri, Ahmed Elsherbini, Simone M. Crivelli, Salim S. El‐Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D. Spassieva, Mariana Nikolova‐Karakashian, Erhard Bieberich   +10 more
doaj   +1 more source

Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold. [PDF]

Eur J Med Chem, 2023
Novotna K, Thomas AG, Stepanek O, Murphy B, Hin N, Skacel J, Mueller L, Tenora L, Pal A, Alt J, Wu Y, Paule J, Rais R, Slusher BS, Tsukamoto T.   +14 more
europepmc   +1 more source