Results 91 to 100 of about 8,477 (148)

Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits

Nature Communications
Extracellular vesicles (EVs) are nano-sized, membrane-delimited, particles released by cells that carry signaling macromolecules. A major pathway of EV production is potentiated by neutral sphingomyelinase 2 (SMPD3/nSMAse2), an enzyme that generates ...
Clair Crewe, Christy M. Gliniak, Toshiharu Onodera, Shiuhwei Chen, Jan-Bernd Funcke, May-Yun Wang, Snigdha Tiash, Yun-Ling Pai, Marjori Russo, Saket Awadhesbhai Patel, Ze Yu, Yi-Cian Zheng, Alex Larkin, Chao Xing, Laurent Gautron, Chun-Kan Chen, Chen Liu, Philipp E. Scherer   +17 more
doaj   +1 more source

Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound. [PDF]

Proc Natl Acad Sci U S A, 2023
Yoo SW, Waheed AA, Deme P, Tohumeken S, Rais R, Smith MD, DeMarino C, Calabresi PA, Kashanchi F, Freed EO, Slusher BS, Haughey NJ.   +11 more
europepmc   +1 more source

Virtual screening reveals aprepitant to be a potent inhibitor of neutral sphingomyelinase 2: implications in blockade of exosome release in cancer therapy. [PDF]

J Cancer Res Clin Oncol, 2023
Moloudizargari M, Hekmatirad S, Gharaghani S, Moghadamnia AA, Najafzadehvarzi H, Asghari MH.   +5 more
europepmc   +1 more source

Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts. [PDF]

Mol Neurobiol, 2022
Zhu Z, Quadri Z, Crivelli SM, Elsherbini A, Zhang L, Tripathi P, Qin H, Roush E, Spassieva SD, Nikolova-Karakashian M, McClintock TS, Bieberich E.   +11 more
europepmc   +1 more source

Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma. [PDF]

J Mol Med (Berl), 2022
Schumacher F, Carpinteiro A, Edwards MJ, Wilson GC, Keitsch S, Soddemann M, Wilker B, Kleuser B, Becker KA, Müller CP, Kornhuber J, Gulbins E.   +11 more
europepmc   +1 more source

Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. [PDF]

Int J Mol Sci, 2023
Pavlic A, Poelman H, Wasilewski G, Wichapong K, Lux P, Maassen C, Lutgens E, Schurgers LJ, Reutelingsperger CP, Nicolaes GAF.   +9 more
europepmc   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling

Journal of Extracellular Biology
Extra‐large extracellular vesicles (XLEVs), with diameters > 600 nm, are increasingly recognised as mediators of specialized modes of intercellular communication; however, the molecular mechanisms governing their biogenesis and functional regulation ...
Shuo Wang, Rio Imai, Yuya Kaneko, Yosuke Tanaka   +3 more
doaj   +1 more source

Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation. [PDF]

Int J Mol Sci, 2022
Álvarez-Fernández H, Mingo-Casas P, Blázquez AB, Caridi F, Saiz JC, Pérez-Pérez MJ, Martín-Acebes MA, Priego EM.   +7 more
europepmc   +1 more source

Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides. [PDF]

Cell Mol Life Sci, 2021
Zietzer A, Jahnel AL, Bulic M, Gutbrod K, Düsing P, Hosen MR, Dörmann P, Werner N, Nickenig G, Jansen F.   +9 more
europepmc   +1 more source