Results 111 to 120 of about 25,021,772 (171)

Neutral Bay.

, 1886
Advertisements on preliminary and final leaves.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map-lfsp1703. The land for sale was "the extensive property held by the late Mr. Patrick Hayes"

core  

The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes [PDF]

, 2015
Background: Exosomes are a novel mechanism of intercellular transmission of infectious prions. Results: Chemical and RNAi inhibition of the neutral sphingomyelinase (nSMase) pathway impairs exosome formation and prion packaging.
Hill, Andrew F, Guo, Belinda B, Bellingham, Shayne A   +2 more
core   +1 more source

Ceramide‐mediated orchestration of oxidative stress response through filopodia‐derived small extracellular vesicles

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H2O2 in Hela cells stimulated filopodia formation and the secretion of EVs.
Zainuddin Quadri, Ahmed Elsherbini, Simone M. Crivelli, Salim S. El‐Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D. Spassieva, Mariana Nikolova‐Karakashian, Erhard Bieberich   +10 more
doaj   +1 more source

Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold. [PDF]

Eur J Med Chem, 2023
Novotna K, Thomas AG, Stepanek O, Murphy B, Hin N, Skacel J, Mueller L, Tenora L, Pal A, Alt J, Wu Y, Paule J, Rais R, Slusher BS, Tsukamoto T.   +14 more
europepmc   +1 more source

Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits

Nature Communications
Extracellular vesicles (EVs) are nano-sized, membrane-delimited, particles released by cells that carry signaling macromolecules. A major pathway of EV production is potentiated by neutral sphingomyelinase 2 (SMPD3/nSMAse2), an enzyme that generates ...
Clair Crewe, Christy M. Gliniak, Toshiharu Onodera, Shiuhwei Chen, Jan-Bernd Funcke, May-Yun Wang, Snigdha Tiash, Yun-Ling Pai, Marjori Russo, Saket Awadhesbhai Patel, Ze Yu, Yi-Cian Zheng, Alex Larkin, Chao Xing, Laurent Gautron, Chun-Kan Chen, Chen Liu, Philipp E. Scherer   +17 more
doaj   +1 more source

Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound. [PDF]

Proc Natl Acad Sci U S A, 2023
Yoo SW, Waheed AA, Deme P, Tohumeken S, Rais R, Smith MD, DeMarino C, Calabresi PA, Kashanchi F, Freed EO, Slusher BS, Haughey NJ.   +11 more
europepmc   +1 more source

Virtual screening reveals aprepitant to be a potent inhibitor of neutral sphingomyelinase 2: implications in blockade of exosome release in cancer therapy. [PDF]

J Cancer Res Clin Oncol, 2023
Moloudizargari M, Hekmatirad S, Gharaghani S, Moghadamnia AA, Najafzadehvarzi H, Asghari MH.   +5 more
europepmc   +1 more source

Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts. [PDF]

Mol Neurobiol, 2022
Zhu Z, Quadri Z, Crivelli SM, Elsherbini A, Zhang L, Tripathi P, Qin H, Roush E, Spassieva SD, Nikolova-Karakashian M, McClintock TS, Bieberich E.   +11 more
europepmc   +1 more source

Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling

Journal of Extracellular Biology
Extra‐large extracellular vesicles (XLEVs), with diameters > 600 nm, are increasingly recognised as mediators of specialized modes of intercellular communication; however, the molecular mechanisms governing their biogenesis and functional regulation ...
Shuo Wang, Rio Imai, Yuya Kaneko, Yosuke Tanaka   +3 more
doaj   +1 more source

Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. [PDF]

Int J Mol Sci, 2023
Pavlic A, Poelman H, Wasilewski G, Wichapong K, Lux P, Maassen C, Lutgens E, Schurgers LJ, Reutelingsperger CP, Nicolaes GAF.   +9 more
europepmc   +1 more source