Results 131 to 140 of about 25,021,772 (171)

The regulation of lipid metabolism in T cells by neutral sphingomyelinase-2 (NSM2)

Accumulation of lipid droplets (LD) and ceramides (Cer) is associated with the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) a condition frequently co-occurring with type 2 diabetes and diminished immune functionality.
openaire   +2 more sources

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. [PDF]

J Biol Chem, 2019
Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA.   +7 more
europepmc   +1 more source

Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. [PDF]

Eur J Med Chem, 2019
Stepanek O, Hin N, Thomas AG, Dash RP, Alt J, Rais R, Rojas C, Slusher BS, Tsukamoto T.   +8 more
europepmc   +1 more source

Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide. [PDF]

Cell Death Dis, 2018
Back MJ, Ha HC, Fu Z, Choi JM, Piao Y, Won JH, Jang JM, Shin IC, Kim DK.   +8 more
europepmc   +1 more source

Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination. [PDF]

Mol Neurobiol, 2018
Tan LH, Tan AJ, Ng YY, Chua JJ, Chew WS, Muralidharan S, Torta F, Dutta B, Sze SK, Herr DR, Ong WY.   +10 more
europepmc   +1 more source

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. [PDF]

Sci Rep, 2018
Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer M, Slusher BS.   +17 more
europepmc   +1 more source

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse. [PDF]

J Neurosci, 2016
Dinkins MB, Enasko J, Hernandez C, Wang G, Kong J, Helwa I, Liu Y, Terry AV, Bieberich E.   +8 more
europepmc   +1 more source

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest. [PDF]

Cell Death Dis, 2015
Shamseddine AA, Clarke CJ, Carroll B, Airola MV, Mohammed S, Rella A, Obeid LM, Hannun YA.   +7 more
europepmc   +1 more source

Sphingolipid Metabolism Links Morphological Signatures to Immunomodulatory Potency in Human Mesenchymal Stromal Cells. [PDF]

Cell Mol Bioeng
Shah DC, Leitmann BW, Priyadarshani P, DeVeaux SA, Munoz C, Zhang Y, Rui K, Chiappa NF, Hymel LA, York W, Ogle ME, Botchwey EA, Mortensen LJ.   +12 more
europepmc   +1 more source

Analysis of membrane topology of neutral sphingomyelinase 2 [PDF]

FEBS Letters, 2007
Neutral sphingomyelinase 2 (nSMase2), which has two hydrophobic segments at its NH2‐terminus, plays an important role in ceramide‐mediated cell regulation. Here, we investigated the membrane topology of nSMase2. When a double‐tagged nSMase2 at both the NH2 and COOH termini, was overexpressed in MCF‐7 cells, the signals from both tags were detected in ...
Yusuf A. Hannun, Motohiro Tani
exaly   +3 more sources