Results 121 to 130 of about 8,477 (148)

Screening for acid sphingomyelinase deficiency in patients with an interstitial lung disease. [PDF]

Orphanet J Rare Dis
Vermant M, Van Raemdonck I, Veyt N, Carlon MS, Cortesi EE, De Crem N, De Rooy M, Follet T, Gogaert S, Vanaudenaerde B, Cassiman D, De Sadeleer LJ, Wuyts WA.   +12 more
europepmc   +1 more source

Neutral Sphingomyelinase 2 [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2011
Abstract Chronic obstructive pulmonary disease (COPD) is caused by exposure to cigarette smoke (CS). One mechanism of CS-induced lung injury is aberrant generation of ceramide, which leads to elevated apoptosis of epithelial and endothelial cells in the alveolar spaces.
Kent Pinkerton, Simone Filosto, Lisa Franzi   +2 more
exaly   +2 more sources

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Identification and evaluation of neutral sphingomyelinase 2 inhibitors

Archives of Pharmacal Research, 2011
Sphingomyelinase catalyzes the hydrolysis of sphingomyelin to generate ceramide, an important molecule involved in the regulation of various cellular responses. In this study, we partially purified the neutral sphingomyelinase2 (nSMase2) and identified the inhibitors, D-lyxophytosphingosine and D-arabino-phytosphingosine, which have an inhibitory ...
Dong Hun, Lee, Sung Hyun, Kim, Kyong Hoon, Ahn, Seok Kyun, Kim, Jong Min, Choi, Jung Eun, Ji, Jong Hoon, Won, Yang Hui, Park, Chaemin, Lim, Sanghee, Kim, Dae Kyong, Kim   +10 more
openaire   +2 more sources

The neutral sphingomyelinase 2 in T cell receptor signaling and polarity

Biological Chemistry, 2018
Abstract By hydrolyzing its substrate sphingomyelin at the cytosolic leaflet of cellular membranes, the neutral sphingomyelinase 2 (NSM2) generates microdomains which serve as docking sites for signaling proteins and thereby, functions to regulate signal relay.
Lena, Collenburg, Sibylle, Schneider-Schaulies, Elita, Avota   +2 more
exaly   +3 more sources

Dopamine transporter trafficking is regulated by neutral sphingomyelinase 2/ceramide kinase

Cellular Signalling, 2018
Dopamine (DA) reuptake is the primary mechanism to terminate dopaminergic transmission in the synaptic cleft. The dopamine transporter (DAT) has an important role in the regulation of DA reuptake. This study provides anatomical and physiological evidence that DAT recycling is regulated by ceramide kinase via the sphingomyelin pathway.
Jong Hoon, Won, Seok Kyun, Kim, In Chul, Shin, Hae Chan, Ha, Ji Min, Jang, Moon Jung, Back, Dae Kyong, Kim   +6 more
openaire   +2 more sources

The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL

Free Radical Biology and Medicine, 2016
Capillaries of the external part of the normal arterial wall constitute the vasa vasorum network. In atherosclerotic lesions, neovascularization occurs in areas of intimal hyperplasia where it may promote plaque expansion, and intraplaque hemorrhage. Oxidized LDL that are present in atherosclerotic areas activate various angiogenic signaling pathways ...
Camare, Caroline, Augé, Nathalie, Pucelle, Mélanie, Saint-Lebes, Bertrand, Grazide, Marie-Hélène, Nègre-Salvayre, Anne, Salvayre, Robert   +6 more
openaire   +2 more sources

Crystal structure and activation mechanism of human neutral sphingomyelinase 2

The FASEB Journal, 2017
Neutral sphingomyelinase 2 (nSMase2) is a magnesium‐dependent phophodiesterase that generates the bioactive sphingolipid ceramide. Ceramide is a critically important secondary messenger that acts in a variety of cellular pathways such as apoptosis, inflammation, cell growth and differentiation.
Prajna Shanbhogue, Michael Airola, Achraf Shamseddine, Kip Guja, Rohan Maini, Nana Bartke, Bill Wu, Lina Obeid, Miguel Garcia‐Diaz, Yusuf Hannun   +9 more
openaire   +1 more source

Neutral sphingomyelinase 2 induces dopamine uptake through regulation of intracellular calcium

Cellular Signalling, 2010
Ceramide serves as a second messenger produced from sphingomyelin by the activation of sphingomyelinase (SMase). Here, we suggest that neutral SMase 2 (nSMase2) may regulate dopamine (DA) uptake. nSMase2 siRNA-transfected PC12 cells showed lower levels of nSMase activity and ceramide than scramble siRNA-transfected and control cells.
Seok Kyun, Kim, Kyong Hoon, Ahn, Jung Eun, Ji, Jong Min, Choi, Hyung Jun, Jeon, Sung Yun, Jung, Kwang Mook, Jung, Dae Kyong, Kim   +7 more
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Down‐regulation of acid sphingomyelinase and neutral sphingomyelinase‐2 inversely determines the cellular resistance to plasmalemmal injury by pore‐forming toxins

The FASEB Journal, 2018
ABSTRACT Bacterial pore‐forming toxins compromise plasmalemmal integrity, leading to Ca 2+ influx, leakage of the cytoplasm, and cell death. Such lesions can be repaired by microvesicular shedding or by the endocytic uptake of the injured membrane sites.
Schönauer, Roman, Larpin, Yu-Noël, Babiichuk, Eduard, Drücker, Patrick, Babiichuk, Viktoriia, Avota, E, Schneider-Schaulies, S, Schumacher, F, Kleusner, B, Köffel, René, Draeger, Annette   +10 more
openaire   +3 more sources

A CRITICAL ROLE FOR NEUTRAL SPHINGOMYELINASE-2 IN DOXORUBICIN-INDUCED CARDIOTOXICITY

ABSTRACT Cardiotoxicity is a major side effect of Doxorubicin (Dox) that has hampered its clinical utility, and strategies to mitigate this cardiotoxicity are limited. Sphingolipids (SL) are central to the chemotherapy response in cancer but their role in normal tissue is less clear.
Samia Mohammed, Victoria Franzi, Ya-Ping Jiang, Fabiola N. Velazquez, Monica E. Alexander, Folnetti A. Alvarez, Danielle Lambadis, Sam B. Chiappone, Anne G. Ostermeyer-Fay, Leiqing Zhang, Achraf A. Shamseddine, Daniel Canals, Ashley J. Snider, Richard Z. Lin, Yusuf A. Hannun, Christopher J. Clarke   +15 more
openaire   +2 more sources