Results 101 to 110 of about 25,021,772 (171)

Chromatin neutral sphingomyelinase and its role in hepatic regeneration

, 1997
Ceramide acts as a second messenger and modulates many cellular functions. This molecule can be produced by enzymatic digestion of sphingomyelin, a phospholipid which has been shown to be in high concentration in a chromatin phospholipidic fraction.
Viola Magni, M. P., ALBI, Elisabetta
core   +1 more source

Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis

Journal of Extracellular Biology
Extracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing off‐target effects and ...
Marlies Burgelman, Pieter Dujardin, Anthony Willems, Tino Hochepied, Griet Van Imschoot, Elien Van Wonterghem, Lien Van Hoecke, Charysse Vandendriessche, Roosmarijn E. Vandenbroucke   +8 more
doaj   +1 more source

Platinum Nanoparticles Enhance Exosome Release in Human Lung Epithelial Adenocarcinoma Cancer Cells (A549): Oxidative Stress and the Ceramide Pathway are Key Players

International Journal of Nanomedicine, 2021
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, KoreaCorrespondence: Sangiliyandi Gurunathan; Jin-Hoi KimDepartment of Stem Cell and ...
Gurunathan S, Kang MH, Jeyaraj M, Kim JH
doaj  

Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide[S]

Journal of Lipid Research, 2010
Data from animal experiments strongly suggest that ceramide is an important mediator of lipotoxicity in the heart and that accumulation of ceramide contributes to cardiomyocyte apoptosis associated with type 2 diabetes and obesity.
Marcin Baranowski, Agnieszka Blachnio-Zabielska, Tomasz Hirnle, Dorota Harasiuk, Krzysztof Matlak, Malgorzata Knapp, Piotr Zabielski, Jan Gorski   +7 more
doaj   +1 more source

Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells

BMC Complementary and Alternative Medicine, 2013
Abstract Background Some of ginsenosides, root extracts from Panax ginseng, exert cytotoxicity against cancer cells through disruption of membrane subdomains called lipid rafts. Protopanaxadiol (PPD) exhibits the highest cytotoxic effect among 8 ginsenosides which we evaluated for anti-cancer activity. We investigated
Park, Bonggoo, Lee, Yong-Moon, Kim, Jae-Sung, Her, Youl, Kang, Ju Hee, Oh, Seung-Hyun, Kim, Hwan-Mook   +6 more
openaire   +3 more sources

Lovastatin reversed the enhanced sphingomyelin caused by 27-hydroxycholesterol in cultured vascular endothelial cells

Biochemistry and Biophysics Reports, 2016
Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Qi Zhou, Allan Luo, Fred A Kummerow
doaj   +1 more source

Apoptosis and signalling in acid sphingomyelinase deficient cells [PDF]

, 2000
Background Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic leaftet of the plasma membrane. Inner leaflet sphingomyelin is then
Sillence Dan J, Dan J Sillence, Sillence, Daniel J.   +2 more
core   +1 more source

ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation[S]

Journal of Lipid Research, 2016
Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional ...
Christopher J. Clarke, Achraf A. Shamseddine, Joseph J. Jacob, Gabrielle Khalife, Tara A. Burns, Yusuf A. Hannun   +5 more
doaj   +1 more source

In silico analysis of neutral sphingomyelinase 2

, 2020
177
openaire   +1 more source

Souris fragilitas ossium et mutation de la sphingomyélinase neutre de type 2 : implication dans l'apoptose et l'ostéochondrogenèse [PDF]

, 2011
Les sphingolipides sont des lipides complexes, qui rentrent dans la composition des membranes, mais sont également des agents de signalisation majeurs, impliqués dans de nombreuses réponses et régulations cellulaires, et dans la physiopathologie de ...
Devillard, Raphaël
core