Results 101 to 110 of about 8,477 (148)

Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. [PDF]

Cancer Immunol Res, 2021
Montfort A, Bertrand F, Rochotte J, Gilhodes J, Filleron T, Milhès J, Dufau C, Imbert C, Riond J, Tosolini M, Clarke CJ, Dufour F, Constantinescu AA, Junior NF, Garcia V, Record M, Cordelier P, Brousset P, Rochaix P, Silvente-Poirot S, Therville N, Andrieu-Abadie N, Levade T, Hannun YA, Benoist H, Meyer N, Micheau O, Colacios C, Ségui B.   +28 more
europepmc   +1 more source

Neutral Sphingomyelinase 2 Is Palmitoylated on Multiple Cysteine Residues [PDF]

Journal of Biological Chemistry, 2007
Motohiro Tani, Yusuf A. Hannun
openaire   +1 more source

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science
Stroke represents a significant threat to public health, with insufficient understanding of its pathological mechanisms hindering therapeutic advancements. Exosomes are implicated in both the injury and recovery processes of ischemic stroke.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
doaj   +1 more source

Secretion and transfer of adipose lipoprotein lipase utilizes neutral sphingomyelinase 2 generated exosomes

ABSTRACT Lipoprotein lipase (LPL) is critical for clearance of circulating triglycerides and for tissue fatty acid supply. LPL is primarily synthesized and secreted by adipocytes into the interstitium and must traffic from there to the abluminal/basolateral side of capillary endothelial cells.
Terri A. Pietka, Edward F. Morris, Megan Basco, Jennifer Shew, Ni-huiping Son, Zhenxiu Liu, Brandon A. Davies, Ira J. Goldberg, Clair Crewe, Nada A. Abumrad   +9 more
openaire   +2 more sources

Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury. [PDF]

Biochem Pharmacol, 2021
Tallon C, Picciolini S, Yoo SW, Thomas AG, Pal A, Alt J, Carlomagno C, Gualerzi A, Rais R, Haughey NJ, Bedoni M, Slusher BS.   +11 more
europepmc   +1 more source

Neutral sphingomyelinase 2 controls exosome secretion by counteracting V-ATPase-mediated endosome acidification.

J Cell Sci, 2022
Choezom D, Gross JC.
europepmc   +1 more source

Proinflammatory Stress Activates Neutral Sphingomyelinase 2-Based Generation of a Ceramide-Enriched β-Cell EV Subpopulation. [PDF]

Diabetes
Xu J, Amalaraj I, De Oliveira A, Harris-Kawano A, Enriquez JR, Mirmira RG, Eder JG, Burnet MC, Díaz Ludovico I, Flores JE, Nakayasu ES, Sims EK.   +11 more
europepmc   +1 more source

Blockade of neutral sphingomyelinase 2 exerts antitumor effect on metastatic castration resistant prostate cancer cells and promotes tumor regression when combined with Enzalutamide. [PDF]

Am J Cancer Res
Shams SG, Dawud D, Michalak K, Makhlouf MM, Moustafa A, Jazwinski SM, Kang L, Zerfaoui M, El Sayed KA, Abd Elmageed ZY.   +9 more
europepmc   +1 more source

The regulation of lipid metabolism in T cells by neutral sphingomyelinase-2 (NSM2)

Accumulation of lipid droplets (LD) and ceramides (Cer) is associated with the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) a condition frequently co-occurring with type 2 diabetes and diminished immune functionality.
openaire   +2 more sources

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. [PDF]

J Biol Chem, 2019
Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA.   +7 more
europepmc   +1 more source