Results 1 to 10 of about 31,322 (227)
Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia [PDF]
Neurobiology of DiseaseLoss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle +12 more
doaj +2 more sources
Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels
Cell Reports, 2020 Summary: Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines.
Jian Shi, Adam J Hyman, Dario De Vecchis
exaly +3 more sources
Targeting sphingolipid metabolism: inhibition of neutral sphingomyelinase 2 impairs coronaviral replication organelle formation [PDF]
mBioMany plus-strand RNA viruses, including coronaviruses, orchestrate the formation of specialized replication organelles in the cytoplasm of infected cells by specific membrane-associated viral nonstructural proteins (nsp’s).
Florian Salisch +5 more
doaj +2 more sources
Heliyon, 2023 Purpose: Leptospirosis is a perplexing mystification for many clinicians. Clinically often underdiagnosed due to lack of a rapid, sensitive, and specific diagnostic test.
A. Ashaiba +3 more
doaj +1 more source
Ceramide Metabolism and Parkinson’s Disease—Therapeutic Targets
Biomolecules, 2021 Ceramide is a bioactive sphingolipid involved in numerous cellular processes. In addition to being the precursor of complex sphingolipids, ceramides can act as second messengers, especially when they are generated at the plasma membrane of cells.
Antía Custodia +8 more
doaj +1 more source
Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination. [PDF]
PLoS ONE, 2017 The cuprizone animal model, also known as the toxic demyelination model, is a well-reproducible model of demyelination- and remyelination in mice, and has been useful in studying important aspect of human demyelinating diseases, including multiple ...
Marwan Chami +7 more
doaj +1 more source
The subcellular localization of neutral sphingomyelinase in rat liver.
Journal of Lipid Research, 1979 The subcellular distribution of neutral sphingomyelinase activity has been determined in rat liver. Neutral sphingomyelinase is present in the plasma membrane.
K Y Hostetler, P J Yazaki
doaj +1 more source
Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis [PDF]
, 2019 Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to ...
Becker, Katrin A. +9 more
core +1 more source
Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide System
Neurosignals, 2016 Background: Melatonin has been shown to have antidepressive effects. We tested whether melatonin inhibits the acid sphingomyelinase/ceramide system and mediates its antidepressive effects via inhibition of the acid sphingomyelinase and a reduction of ...
Richard Hoehn +11 more
doaj +1 more source
Biomolecules, 2023 Acid ceramidase (AC) is a lysosomal enzyme required to hydrolyze ceramide to sphingosine by the removal of the fatty acid moiety. An inherited deficiency in this activity results in two disorders, Farber Lipogranulomatosis and spinal muscular atrophy ...
Xingxuan He, Edward H. Schuchman
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