Results 11 to 20 of about 23,449 (215)
Regulation of Arthritis Severity by the Acid Sphingomyelinase
Cellular Physiology and Biochemistry, 2017 Background/Aims: Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities ...
Nadine Beckmann +10 more
doaj +2 more sources
VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation [PDF]
Canadian Journal of Gastroenterology, 2008 BACKGROUND: Alkaline sphingomyelinase, an enzyme found exclusively in bile and the intestinal brush border, hydrolyzes sphingomyelin into ceramide, sphingosine and sphingosine-1-phosphate, thereby inducing epithelial apoptosis. Reduced levels of alkaline
Isaac Soo +9 more
doaj +2 more sources
Sphingomyelinase in Pig and Human Epidermis [PDF]
Journal of Investigative Dermatology, 1978 The enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which hydrolyzes sphingomyelin to ceramide (N-acylsphingosine) and phosphorylcholine was identified in the subcellular fractions of pig and human epidermis. The enzyme has an optimum pH of 4.5 to 5 and is activated by Triton X-100 (0.1% w/v).
Bowser, Paul A., Maurice Gray, G.
openaire +3 more sources
Role of sph2 Gene Regulation in Hemolytic and Sphingomyelinase Activities Produced by Leptospira interrogans. [PDF]
PLoS Neglected Tropical Diseases, 2015 Pathogenic members of the genus Leptospira are the causative agents of leptospirosis, a neglected disease of public and veterinary health concern. Leptospirosis is a systemic disease that in its severest forms leads to renal insufficiency, hepatic ...
Suneel A Narayanavari +4 more
doaj +3 more sources
Apoptosis and signalling in acid sphingomyelinase deficient cells [PDF]
BMC Cell Biology, 2001 Background Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic leaftet of the plasma membrane. Inner leaflet sphingomyelin is then
Sillence Dan J
doaj +2 more sources
Frontiers in Immunology, 2021 Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive sphingomyelinases is a hallmark of adaptive responses and cellular repair.
Murad Abusukhun +15 more
doaj +2 more sources
Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis [PDF]
, 2023 Atherosclerosis, a leading cause of cardiovascular diseases requires approaches to enhance disease monitoring and treatment. Nanoparticles offer promising potential in this area by being customisable to target components or molecular processes within ...
Jesús, Ruiz-Cabello +5 more
core +1 more source
Sphingomyelinases and Liver Diseases [PDF]
Biomolecules, 2020 Sphingolipids (SLs) are critical components of membrane bilayers that play a crucial role in their physico-chemical properties. Ceramide is the prototype and most studied SL due to its role as a second messenger in the regulation of multiple signaling pathways and cellular processes.
Naroa Insausti-Urkia +3 more
openaire +4 more sources
Acid Sphingomyelinase Deficiency Ameliorates Farber Disease [PDF]
, 2019 Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan.
Michael J. Edwards +21 more
core +2 more sources
Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties [PDF]
, 2015 This work was supported by National Institute of Mental Health grants: P30 MH075673-06 to BSS, CR, NJH and JCM; R01 MH096636 and R01 MH077542 to NJH (http://projectreporter.nih.gov/reporter.cfm); and The Johns Hopkins Brain Science Institute to BSS ...
Justin C. McArthur (66539) +35 more
core +2 more sources