Results 21 to 30 of about 23,449 (215)

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan   +2 more
core   +1 more source

Physiological functions and therapeutic applications of neutral sphingomyelinase and acid sphingomyelinase

Biomedicine & Pharmacotherapy, 2021
Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase (NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can regulate cell growth and apoptosis. Increasing evidence shows that NSM and ASM play key roles in many processes, such as apoptosis, immune function and inflammation.
Hongjiao, Xiang, Shengjie, Jin, Fenglang, Tan, Yifan, Xu, Yifei, Lu, Tao, Wu   +5 more
openaire   +2 more sources

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure [PDF]

, 2012
Contains fulltext : 107961.pdf (Publisher’s version ) (Open Access)Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Dinkla, S., Brock, R.E., Dinkla, S, Cluitmans, JC, Fuchs, B, Joosten, I, Fransen, J., Tomelleri, C, Verdurmen, W.P.R., Bosman, G.J.C.G.M., Wessels, K, Schiller, J., Wessels, K., Brock, R, Fuchs, B., Verdurmen, WP, Joosten, I., Bosman, GJ, Cluitmans, J.C.A., Schiller, J, Tomelleri, C., Fransen, J   +21 more
core   +2 more sources

Acid sphingomyelinase deficiency ameliorates Farber disease

, 2021
Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan.
Kleuser, Burkhard (Prof. Dr. rer. nat.), Beckmann, Nadine, Kühn, Claudine, Gulbins, Erich, Schulz-Schaeffer, Walter J., Carpinteiro, Alexander, Becker, Katrin Anne, Edwards, Michael J., Kramer, Melanie, Kadow, Stephanie, Schumacher, Fabian (Dr.)   +10 more
core   +1 more source

Multiple leptospiral sphingomyelinases (or are there?) [PDF]

Microbiology, 2012
Culture supernatants of leptospiral pathogens have long been known to haemolyse erythrocytes. This property is due, at least in part, to sphingomyelinase activity. Indeed, genome sequencing reveals that pathogenic Leptospira species are richly endowed with sphingomyelinase homologues: five genes have been annotated to encode sphingomyelinases in ...
Suneel A, Narayanavari, Manjula, Sritharan, David A, Haake, James, Matsunaga   +3 more
openaire   +3 more sources

Phospholipases and Membrane Curvature: What Is Happening at the Surface?

Membranes, 2023
In this revision work, we emphasize the close relationship between the action of phospholipases and the modulation of membrane curvature and curvature stress resulting from this activity.
María Laura Fanani, Ernesto Esteban Ambroggio   +1 more
doaj   +1 more source

Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxins. [PDF]

, 2019
Bacterial pore-forming toxins compromise plasmalemmal integrity, leading to Ca2+ influx, leakage of the cytoplasm, and cell death. Such lesions can be repaired by microvesicular shedding or by the endocytic uptake of the injured membrane sites.
Roman Schoenauer, Patrick Drücker, Draeger, Annette, Yu Larpin, Eduard B. Babiychuk, Viktoriia S. Babiychuk, Schönauer, Roman, Elita Avota, Fabian Schumacher, Annette Draeger, Schneider-Schaulies, S, Schumacher, F, Avota, E, Drücker, Patrick, Burkhard Kleuser, Babiychuk, Eduard, Babiychuk, Victoria, Larpin, Yu-Noël, Sibylle Schneider-Schaulies, René Köffel, Köffel, René, Kleusner, B   +21 more
core   +1 more source

Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells

Mediators of Inflammation, 2017
Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation, proliferation, and apoptosis. Although previous studies have reported the involvement of neutral sphingomyelinase in hippocampus physiopathology, its behavior in the ...
Samuela Cataldi, Cataldo Arcuri, Stéphane Hunot, François-Pierre Légeron, Carmen Mecca, Mercedes Garcia-Gil, Andrea Lazzarini, Michela Codini, Tommaso Beccari, Anna Tasegian, Bernard Fioretti, Giovanna Traina, Francesco Saverio Ambesi-Impiombato, Francesco Curcio, Elisabetta Albi   +14 more
doaj   +1 more source

Impact of HepG2 Cells Glutathione Depletion on Neutral Sphingomyelinases mRNA Levels and Activity

Current Issues in Molecular Biology, 2023
Liver cancer is a prevalent form of cancer worldwide. While research has shown that increasing sphingomyelin (SM) hydrolysis by activating the cell surface membrane-associated neutral sphingomyelinase 2 (nSMase2) can control cell proliferation and ...
Marie Gamal, Hatem Tallima, Hassan M. E. Azzazy, Anwar Abdelnaser   +3 more
doaj   +1 more source

Crystal structure of mammalian acid sphingomyelinase

Nature Communications, 2016
Mutations in acid sphingomyelinase result in toxic accumulation of sphingomyelin and cause Niemann-Pick disease. Here, the authors report structures of mammalian acid sphingomyelinase, which reveal details of the molecular mechanism of acid ...
Alexei Gorelik, Katalin Illes, Leonhard X. Heinz, Giulio Superti-Furga, Bhushan Nagar   +4 more
doaj   +1 more source