Results 21 to 30 of about 18,841 (183)
Thematic Review Series: Sphingolipids. Nuclear sphingolipids: metabolism and signaling*
Journal of Lipid Research, 2008 Sphingolipids are most prominently expressed in the plasma membrane, but recent studies have pointed to important signaling and regulatory roles in the nucleus.
Robert W. Ledeen, Gusheng Wu
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Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation
Biomolecules, 2014 The sphingolipids are one of the major lipid families in eukaryotes, incorporating a diverse array of structural variants that exert a powerful influence over cell fate and physiology. Increased expression of sphingosine kinase 1 (SPHK1), which catalyses
Anthony S. Don +2 more
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Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases [PDF]
FEBS Letters, 2004 Sphingosylphosphocholine (SPC), the N‐deacylated form of sphingomyelin (SM), is a naturally occurring lipid mediator. However, little is known about the metabolism of SPC. We here report an in vitro assay system for SPC‐phospholipase C (PLC). Using this assay system, we demonstrated that nSMase1 and nSMase2, human neutral sphingomyelinases (SMases ...
Miura, Yukiko +4 more
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Journal of Lipid Research, 2005 Interleukin-1β (IL-1β) is a major inducer of liver acute-phase protein expression in response to infection. Several transcription factors, including CCAAT/enhancer binding protein (C/EBP), are known mediators in this process, although the mechanisms by ...
Natalia V. Giltiay +4 more
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Ceramide as a Target of Marine Triterpene Glycosides for Treatment of Human Myeloid Leukemia
Marine Drugs, 2016 Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood.
Seong-Hoon Yun +3 more
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Sphingomyelinase D, a novel probe for cellular sphingomyelin
Journal of Lipid Research, 2003 Sphingomyelin (SM) and free cholesterol (FC) are concentrated in the plasma membranes of eukaryotes; however, the physiological significance of their association is unclear.
Papasani V. Subbaiah +4 more
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Biomedicines, 2022 Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract, resulting in severe symptoms. At the moment, the goal of medical treatments is to reduce inflammation. IBD is treated with systemic anti-inflammatory
Tuula Penate Medina +7 more
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Journal of Lipid Research, 2006 We previously reported that human Niemann-Pick Disease type B (NPD-B) is associated with low HDL. In this study, we investigated the pathophysiology of this HDL deficiency by examining both HDL samples from NPD-B patients and nascent high density ...
Ching Yin Lee +8 more
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Role of sph2 Gene Regulation in Hemolytic and Sphingomyelinase Activities Produced by Leptospira interrogans. [PDF]
PLoS Neglected Tropical Diseases, 2015 Pathogenic members of the genus Leptospira are the causative agents of leptospirosis, a neglected disease of public and veterinary health concern. Leptospirosis is a systemic disease that in its severest forms leads to renal insufficiency, hepatic ...
Suneel A Narayanavari +4 more
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Journal of Lipid Research, 2013 Light-induced retinal degeneration (LIRD) in albino rats causes apoptotic photoreceptor cell death. Ceramide is a second messenger for apoptosis. We tested whether increases in ceramide mediate photoreceptor apoptosis in LIRD and if inhibition of ...
Hui Chen +6 more
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