Results 1 to 10 of about 9,480 (220)

Acid ceramidase regulates innate immune memory [PDF]

Cell Reports, 2023
Summary: Innate immune memory, also called ''trained immunity,'' is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions.
Nils Rother, Cansu Yanginlar, Mandy M T Van Leent   +2 more
exaly   +8 more sources

Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells [PDF]

Lipids in Health and Disease, 2008
Background The ceramide generation is an early event in the apoptotic response to numerous stimuli including the oxidative stress and ceramide analogs mimic the stress effect and induce apoptosis.
Shakhova Elena G, Babenko Nataliya A
doaj   +4 more sources

The role of ACER2 in intestinal sphingolipid metabolism and gastrointestinal cancers [PDF]

Frontiers in Immunology
Sphingolipids, particularly sphingosine-1-phosphate (S1P), are bioactive lipids involved in regulating cellular processes such as proliferation, apoptosis, inflammation, and tumor progression.
Binggang Liu, Junfeng Zhou, Biao Jiang, Bing Tang, Ting Liu, Pengcheng Lei   +5 more
doaj   +2 more sources

Molecular Targeting of Acid Ceramidase in Glioblastoma: A Review of Its Role, Potential Treatment, and Challenges

Pharmaceutics, 2018
Glioblastoma is the most common, malignant primary tumor of the central nervous system. The average prognosis for life expectancy after diagnosis, with the triad of surgery, chemotherapy, and radiation therapy, is less than 1.5 years.
Ha S Nguyen, Ahmed J Awad, Saman Shabani
exaly   +3 more sources

Lipid-lowering drugs affect lung cancer risk via sphingolipid metabolism: a drug-target Mendelian randomization study

Frontiers in Genetics, 2023
Background: The causal relationship between lipid-lowering drug (LLD) use and lung cancer risk is controversial, and the role of sphingolipid metabolism in this effect remains unclear.Methods: Genome-wide association study data on low-density lipoprotein
Honglin Li, Lei Zhang, Feiran Yang, Xiaoteng Feng, Rong Fu, Ruohan Zhao, Xiurong Li, Huijie Li   +7 more
doaj   +1 more source

Acid Ceramidase Protects Against Hepatic Ischemia/Reperfusion Injury by Modulating Sphingolipid Metabolism and Reducing Inflammation and Oxidative Stress

Frontiers in Cell and Developmental Biology, 2021
Ceramide is a bioactive signaling lipid involved in the pathogenesis of numerous diseases. It also plays an important role in ischemia reperfusion (IR) injury via activation of inflammatory/oxidative stress-stimulated signaling pathways, resulting in ...
Yuan Jiang, Yuan Jiang, Xingxuan He, Calogera M. Simonaro, Bin Yi, Edward H. Schuchman   +5 more
doaj   +1 more source

Digestion and Absorption of Milk Phospholipids in Newborns and Adults

Frontiers in Nutrition, 2021
Milk polar lipids provide choline, ethanolamine, and polyunsaturated fatty acids, which are needed for the growth and plasticity of the tissues in a suckling child.
Åke Nilsson, Rui-Dong Duan, Lena Ohlsson   +2 more
doaj   +1 more source

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]

, 2020
CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun, Cloots, Eva, De Geest, Bruno, Drennan, Michael, Elewaut, Dirk, Gaublomme, Djoere, Govindarajan, Srinath, Gysens, Fien, Janssens, Sophie, Maelegheer, Margaux, Moody, D Branch, Venken, Koen, Verheugen, Eveline   +12 more
core   +2 more sources

Identification of a Novel Acid Sphingomyelinase Activity Associated with Recombinant Human Acid Ceramidase

Biomolecules, 2023
Acid ceramidase (AC) is a lysosomal enzyme required to hydrolyze ceramide to sphingosine by the removal of the fatty acid moiety. An inherited deficiency in this activity results in two disorders, Farber Lipogranulomatosis and spinal muscular atrophy ...
Xingxuan He, Edward H. Schuchman
doaj   +1 more source

Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration

Cells, 2020
Ceramide and sphingosine are important interconvertible sphingolipid metabolites which govern various signaling pathways related to different aspects of cell survival and senescence. The conversion of ceramide into sphingosine is mediated by ceramidases.
Carolina Duarte, Juliet Akkaoui, Chiaki Yamada, Anny Ho, Cungui Mao, Alexandru Movila   +5 more
doaj   +1 more source