Results 1 to 10 of about 5,372 (115)
Acid ceramidase regulates innate immune memory
Cell Reports, 2023 Summary: Innate immune memory, also called ''trained immunity,'' is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions.
Nils Rother +2 more
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Emerging roles of CREST superfamily members in lipid metabolism [PDF]
Journal of Lipid ResearchCREST superfamily members are a series of multi-transmembrane proteins conserved across a wide range of species. There are approximately 20 members in mammals.
Takuma Takagaki +3 more
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Ceramidase is involved in metabolic reprogramming of fibroblasts under hypoxia conditions [PDF]
Frontiers in PhysiologyIntroductionPhysiological metabolic reprogramming is a cells strategy to resist/counteract stress to preserve homeostasis. Hypoxia is an important stress stimulus that can promote tissue remodeling and fibrosis, in which alterations in sphingolipid ...
Michela Terlizzi +10 more
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Intestinal neutral ceramidase exacerbates MASH pathogenesis [PDF]
eGastroenterologyBackground Metabolic dysfunction-associated steatotic liver disease and its more severe manifestation, metabolic dysfunction-associated steatohepatitis (MASH), are intimately linked to genetic factors, gut microbiota and barrier alteration.
Chao Lei +10 more
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Pharmaceutics, 2018 Glioblastoma is the most common, malignant primary tumor of the central nervous system. The average prognosis for life expectancy after diagnosis, with the triad of surgery, chemotherapy, and radiation therapy, is less than 1.5 years.
Saman Shabani, Ninh Doan, Ha Son Nguyen
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Frontiers in Genetics, 2023 Background: The causal relationship between lipid-lowering drug (LLD) use and lung cancer risk is controversial, and the role of sphingolipid metabolism in this effect remains unclear.Methods: Genome-wide association study data on low-density lipoprotein
Honglin Li +7 more
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Frontiers in Cell and Developmental Biology, 2021 Ceramide is a bioactive signaling lipid involved in the pathogenesis of numerous diseases. It also plays an important role in ischemia reperfusion (IR) injury via activation of inflammatory/oxidative stress-stimulated signaling pathways, resulting in ...
Yuan Jiang +5 more
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Digestion and Absorption of Milk Phospholipids in Newborns and Adults
Frontiers in Nutrition, 2021 Milk polar lipids provide choline, ethanolamine, and polyunsaturated fatty acids, which are needed for the growth and plasticity of the tissues in a suckling child.
Åke Nilsson +2 more
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Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration
Cells, 2020 Ceramide and sphingosine are important interconvertible sphingolipid metabolites which govern various signaling pathways related to different aspects of cell survival and senescence. The conversion of ceramide into sphingosine is mediated by ceramidases.
Carolina Duarte +5 more
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Biomolecules, 2023 Acid ceramidase (AC) is a lysosomal enzyme required to hydrolyze ceramide to sphingosine by the removal of the fatty acid moiety. An inherited deficiency in this activity results in two disorders, Farber Lipogranulomatosis and spinal muscular atrophy ...
Xingxuan He, Edward H. Schuchman
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