Acid ceramidase regulates innate immune memory [PDF]
Cell Reports, 2023 Summary: Innate immune memory, also called ''trained immunity,'' is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions.
Nils Rother +24 more
doaj +11 more sources
The Acid Ceramidase Is a SARS-CoV-2 Host Factor [PDF]
Cells, 2022 SARS-CoV-2 variants such as the delta or omicron variants, with higher transmission rates, accelerated the global COVID-19 pandemic. Thus, novel therapeutic strategies need to be deployed.
Nina Geiger +14 more
doaj +8 more sources
Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling [PDF]
Cells, 2022 Glioblastoma (GBM) remains one of the most aggressive cancers, partially due to its ability to migrate into the surrounding brain. The sphingolipid balance, or the balance between ceramides and sphingosine-1-phosphate, contributes to the ability of GBM ...
Cyntanna C. Hawkins +12 more
doaj +5 more sources
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer [PDF]
Cells, 2020 Previous work utilizing proteomic and immunohistochemical analyses has identified that high levels of acid ceramidase (AC) expression confers a poorer response to neoadjuvant treatment in locally advanced rectal cancer.
Rachael E. Clifford +11 more
doaj +8 more sources
Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction [PDF]
Respiratory Research, 2023 Background Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and efficiency of acid ceramidase gene
Michael G. Katz +7 more
doaj +3 more sources
Acid Ceramidase Deficiency [PDF]
Neurol GenetBackground and Objectives Spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME) due to acid ceramidase deficiency is a rare disorder, allelic with Farber disease, resulting from recessive ASAH1 variants.
Silvestre Cuinat +16 more
semanticscholar +4 more sources
Adiponectin overexpression improves metabolic abnormalities caused by acid ceramidase deficiency but does not prolong lifespan in a mouse model of Farber Disease [PDF]
Molecular Genetics and Metabolism ReportsFarber Disease is a debilitating and lethal childhood disease of ceramide accumulation caused by acid ceramidase deficiency. The potent induction of a ligand-gated neutral ceramidase activity promoted by adiponectin may provide sufficient lowering of ...
Marie K. Norris +8 more
doaj +3 more sources
Potential role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights [PDF]
Cell Communication and Signaling, 2022 Acute myeloid leukemia (AML) is a type of leukemia with a poor prognosis and survival characterized by abnormal cell proliferation and differentiation.
Hamidreza Zalpoor +9 more
doaj +3 more sources
Identification of a Novel Acid Sphingomyelinase Activity Associated with Recombinant Human Acid Ceramidase [PDF]
Biomolecules, 2023 Acid ceramidase (AC) is a lysosomal enzyme required to hydrolyze ceramide to sphingosine by the removal of the fatty acid moiety. An inherited deficiency in this activity results in two disorders, Farber Lipogranulomatosis and spinal muscular atrophy ...
Xingxuan He, Edward H. Schuchman
doaj +3 more sources
Targeting acid ceramidase enhances antitumor immune response in colorectal cancer [PDF]
Journal of Advanced Research, 2023 Introduction: Acid ceramidase (hereafter referred as ASAH1) is an enzyme in sphingolipid metabolism that converts pro-survival ceramide into sphingosine. ASAH1 has been shown to be overexpressed in certain cancers.
Yadu Vijayan +8 more
doaj +3 more sources