Results 1 to 10 of about 2,521,035 (177)

Acid ceramidase regulates innate immune memory [PDF]

Cell Reports, 2023
Summary: Innate immune memory, also called ''trained immunity,'' is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions.
Nils Rother, Cansu Yanginlar, Geoffrey Prévot, Inge Jonkman, Maaike Jacobs, Mandy M.T. van Leent, Julia van Heck, Vasiliki Matzaraki, Anthony Azzun, Judit Morla-Folch, Anna Ranzenigo, William Wang, Roy van der Meel, Zahi A. Fayad, Niels P. Riksen, Luuk B. Hilbrands, Rik G.H. Lindeboom, Joost H.A. Martens, Michiel Vermeulen, Leo A.B. Joosten, Mihai G. Netea, Willem J.M. Mulder, Johan van der Vlag, Abraham J.P. Teunissen, Raphaël Duivenvoorden   +24 more
doaj   +12 more sources

The Acid Ceramidase Is a SARS-CoV-2 Host Factor [PDF]

Cells, 2022
SARS-CoV-2 variants such as the delta or omicron variants, with higher transmission rates, accelerated the global COVID-19 pandemic. Thus, novel therapeutic strategies need to be deployed.
Nina Geiger, Louise Kersting, Jan Schlegel, Linda Stelz, Sofie Fähr, Viktoria Diesendorf, Valeria Roll, Marie Sostmann, Eva-Maria König, Sebastian Reinhard, Daniela Brenner, Sibylle Schneider-Schaulies, Markus Sauer, Jürgen Seibel, Jochen Bodem   +14 more
doaj   +6 more sources

Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer [PDF]

Cells, 2020
Previous work utilizing proteomic and immunohistochemical analyses has identified that high levels of acid ceramidase (AC) expression confers a poorer response to neoadjuvant treatment in locally advanced rectal cancer.
Rachael E. Clifford, Naren Govindarajah, David Bowden, Paul Sutton, Mark Glenn, Mahnaz Darvish-Damavandi, Simon Buczacki, Ultan McDermott, Zdzislaw Szulc, Besim Ogretmen, Jason L. Parsons, Dale Vimalachandran   +11 more
doaj   +8 more sources

Targeting acid ceramidase enhances antitumor immune response in colorectal cancer [PDF]

Journal of Advanced Research
Introduction: Acid ceramidase (hereafter referred as ASAH1) is an enzyme in sphingolipid metabolism that converts pro-survival ceramide into sphingosine. ASAH1 has been shown to be overexpressed in certain cancers.
Yadu Vijayan, Shirley James, Arun Viswanathan, Jayasekharan S Aparna, Anu Bindu, Narayanan N Namitha, Devasena Anantharaman, Manendra Babu Lankadasari, Kuzhuvelil B Harikumar   +8 more
doaj   +4 more sources

Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction [PDF]

Respiratory Research, 2023
Background Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and efficiency of acid ceramidase gene
Michael G. Katz, Yoav Hadas, Adam Vincek, Lina Freage-Kahn, Nataly Shtraizent, Jeko M. Madjarov, Peter Pastuszko, Efrat Eliyahu   +7 more
doaj   +2 more sources

High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC inhibitors has attracted increasing ...
Mazen Aseeri, José Luis Abad, Antonio Delgado, Gemma Fabriàs, Gemma Triola, Josefina Casas   +5 more
doaj   +2 more sources

Identification of a Novel Acid Sphingomyelinase Activity Associated with Recombinant Human Acid Ceramidase [PDF]

Biomolecules, 2023
Acid ceramidase (AC) is a lysosomal enzyme required to hydrolyze ceramide to sphingosine by the removal of the fatty acid moiety. An inherited deficiency in this activity results in two disorders, Farber Lipogranulomatosis and spinal muscular atrophy ...
Xingxuan He, Edward H. Schuchman
doaj   +2 more sources

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization. [PDF]

J Pathol
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Takada M, Sashikawa-Kimura M, Ohno Y, Hossain MR, Xie X, Iwabuchi K, Komine M, Ohtsuki M, Imokawa G.   +8 more
europepmc   +2 more sources

Potential role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights [PDF]

Cell Communication and Signaling, 2022
Acute myeloid leukemia (AML) is a type of leukemia with a poor prognosis and survival characterized by abnormal cell proliferation and differentiation.
Hamidreza Zalpoor, Maryam Bakhtiyari, Abdullatif Akbari, Fatemeh Aziziyan, Hooriyeh Shapourian, Mahsa Liaghat, Zahra Zare-Badie, Sheida Yahyazadeh, Vahideh Tarhriz, Mazdak Ganjalikhani-Hakemi   +9 more
doaj   +2 more sources

Adiponectin overexpression improves metabolic abnormalities caused by acid ceramidase deficiency but does not prolong lifespan in a mouse model of Farber Disease [PDF]

Molecular Genetics and Metabolism Reports
Farber Disease is a debilitating and lethal childhood disease of ceramide accumulation caused by acid ceramidase deficiency. The potent induction of a ligand-gated neutral ceramidase activity promoted by adiponectin may provide sufficient lowering of ...
Marie K. Norris, Trevor S. Tippetts, Joseph L. Wilkerson, Rebekah J. Nicholson, J. Alan Maschek, Thierry Levade, Jeffrey A. Medin, Scott A. Summers, William L. Holland   +8 more
doaj   +2 more sources