Acid ceramidase regulates innate immune memory [PDF]
Cell Reports, 2023 Summary: Innate immune memory, also called ''trained immunity,'' is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions.
Nils Rother +24 more
doaj +8 more sources
The Acid Ceramidase Is a SARS-CoV-2 Host Factor [PDF]
Cells, 2022 SARS-CoV-2 variants such as the delta or omicron variants, with higher transmission rates, accelerated the global COVID-19 pandemic. Thus, novel therapeutic strategies need to be deployed.
Nina Geiger +14 more
doaj +5 more sources
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer [PDF]
Cells, 2020 Previous work utilizing proteomic and immunohistochemical analyses has identified that high levels of acid ceramidase (AC) expression confers a poorer response to neoadjuvant treatment in locally advanced rectal cancer.
Rachael E. Clifford +11 more
doaj +6 more sources
Targeting acid ceramidase enhances antitumor immune response in colorectal cancer [PDF]
Journal of Advanced ResearchIntroduction: Acid ceramidase (hereafter referred as ASAH1) is an enzyme in sphingolipid metabolism that converts pro-survival ceramide into sphingosine. ASAH1 has been shown to be overexpressed in certain cancers.
Yadu Vijayan +8 more
doaj +4 more sources
Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction [PDF]
Respiratory Research, 2023 Background Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and efficiency of acid ceramidase gene
Michael G. Katz +7 more
doaj +2 more sources
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC inhibitors has attracted increasing ...
Mazen Aseeri +5 more
doaj +2 more sources
Acid ceramidase promotes senescent cell survival. [PDF]
Aging (Albany NY), 2021 Cellular senescence is linked to chronic age-related diseases including atherosclerosis, diabetes, and neurodegeneration. Compared to proliferating cells, senescent cells express distinct subsets of proteins. In this study, we used cultured human diploid fibroblasts rendered senescent through replicative exhaustion or ionizing radiation to identify ...
Munk R +13 more
europepmc +3 more sources
Acid Ceramidase Protects Against Hepatic Ischemia/Reperfusion Injury by Modulating Sphingolipid Metabolism and Reducing Inflammation and Oxidative Stress [PDF]
Frontiers in Cell and Developmental Biology, 2021 Ceramide is a bioactive signaling lipid involved in the pathogenesis of numerous diseases. It also plays an important role in ischemia reperfusion (IR) injury via activation of inflammatory/oxidative stress-stimulated signaling pathways, resulting in ...
Yuan Jiang +5 more
doaj +2 more sources
Potential role of autophagy induced by FLT3-ITD and acid ceramidase in acute myeloid leukemia chemo-resistance: new insights [PDF]
Cell Communication and Signaling, 2022 Acute myeloid leukemia (AML) is a type of leukemia with a poor prognosis and survival characterized by abnormal cell proliferation and differentiation.
Hamidreza Zalpoor +9 more
doaj +2 more sources
Identification of a Novel Acid Sphingomyelinase Activity Associated with Recombinant Human Acid Ceramidase [PDF]
Biomolecules, 2023 Acid ceramidase (AC) is a lysosomal enzyme required to hydrolyze ceramide to sphingosine by the removal of the fatty acid moiety. An inherited deficiency in this activity results in two disorders, Farber Lipogranulomatosis and spinal muscular atrophy ...
Xingxuan He, Edward H. Schuchman
doaj +2 more sources