Results 11 to 20 of about 2,521,035 (177)
Pharmaceutics, 2018 Glioblastoma is the most common, malignant primary tumor of the central nervous system. The average prognosis for life expectancy after diagnosis, with the triad of surgery, chemotherapy, and radiation therapy, is less than 1.5 years.
Ha S. Nguyen +3 more
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Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. [PDF]
PLoS ONE, 2017 Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer.
Aiping Bai +5 more
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Development of an acid ceramidase activity-based probe
Chemical Communications, 2015 Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease.
Overkleeft, Herman S. +9 more
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PLoS ONE, 2013 The tumor suppressor PTEN is now understood to regulate cellular processes at the cytoplasmic membrane, where it classically regulates PI3K signaling, as well as in the nucleus where multiple roles in controlling cell cycle and genome stability have been
Thomas H Beckham +5 more
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Infection and Drug Resistance, 2023 Qian Qi,1,2,* Jiawei Xu,1,2,* Yujiao Wang,3,* Jian Zhang,1 Mingxia Gao,1 Yu Li,4 Liang Dong1,2 1Department of Respiratory, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong ...
Qi Q +6 more
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Structural basis for the activation of acid ceramidase [PDF]
Nature Communications, 2018 Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insight ...
Ahmad Gebai +4 more
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Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis [PDF]
Frontiers in Medicine, 2022 Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide, and is characterized by the accumulation of fat in the liver.
Amy Yu +11 more
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Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling [PDF]
Cells, 2022 Glioblastoma (GBM) remains one of the most aggressive cancers, partially due to its ability to migrate into the surrounding brain. The sphingolipid balance, or the balance between ceramides and sphingosine-1-phosphate, contributes to the ability of GBM ...
Cyntanna C. Hawkins +12 more
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Acid ceramidase deficiency: Farber disease and SMA-PME [PDF]
Orphanet Journal of Rare Diseases, 2018 Acid ceramidase (ACDase) deficiency is a spectrum of disorders that includes a rare lysosomal storage disorder called Farber disease (FD) and a rare epileptic disorder called spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME).
Fabian P. S. Yu +3 more
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Vectors for the treatment of acid ceramidase deficiency
, 2021 The present invention relates to a vector comprising an ASAH1 open reading frame, for use in the treatment of acid ceramidase deficiency.La présente invention concerne un vecteur comprenant un cadre de lecture ouvert ASAH1, destiné à être utilisé dans le
Marinello, Martina +2 more
core +5 more sources