Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization [PDF]
J PatholCeramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and ...
Mariko Takada +8 more
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Acid ceramidase promotes senescent cell survival [PDF]
Aging (Albany NY), 2021 Cellular senescence is linked to chronic age-related diseases including atherosclerosis, diabetes, and neurodegeneration. Compared to proliferating cells, senescent cells express distinct subsets of proteins. In this study, we used cultured human diploid
R. Munk +12 more
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Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis [PDF]
Frontiers in Medicine, 2022 Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide, and is characterized by the accumulation of fat in the liver.
Amy Yu +11 more
doaj +3 more sources
Acid ceramidase expression and biomarker potential in patients with locally advanced rectal cancer [PDF]
Biomol BiomedAcid ceramidase (AC), a pivotal enzyme in sphingolipid metabolism, has been associated with various cancers; however, its specific role in rectal cancer remains poorly understood.
Jasna Bjelanović +4 more
semanticscholar +2 more sources
Inhibitory effect of Porphyromonas gingivalis‐derived phosphoethanolamine dihydroceramide on acid ceramidase expression in oral squamous cells [PDF]
J Cell Mol Med, 2023 The maintenance of diminished acid ceramidase (ASAH1) gene expression leading to the accumulation of antiproliferative intracellular ceramides in oral squamous cell carcinoma (OSCC) has emerged as a prospective oral cancer therapeutic regimen.
Chiaki Yamada +7 more
semanticscholar +2 more sources
Acid ceramidase as a novel target for adiponectin receptor agonist to abrogate podocyte NLRP3 inflammasome activation and glomerular inflammation during obesity [PDF]
J Pharmacol Exp TherAdiponectin receptor (AdipoR) agonists protect against glomerular inflammation and injury in obesity-related glomerulopathy (ORG), but their molecular mechanisms remain unclear.
Guangbi Li +8 more
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Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1 [PDF]
Front ImmunolBesides its robust antiviral activity, type I interferon (IFN-I) also exerts immunomodulatory effects and can even drive pathology during chronic viral infections.
Zhongwen Hu +16 more
semanticscholar +2 more sources
Spinal muscular atrophy-like phenotype in a mouse model of acid ceramidase deficiency [PDF]
Commun Biol, 2023 Mutations in ASAH1 have been linked to two allegedly distinct disorders: Farber disease (FD) and spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME).
Murtaza S. Nagree +13 more
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Inhibition or genetic reduction of ASAH1/acid ceramidase restore α-synuclein clearance in mutant GBA1 dopamine neurons from Parkinson’s patients [PDF]
Hum Mol GenetBi-allelic mutations in GBA1, a gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase), cause Gaucher disease (GD). Although GD carriers do not exhibit clinical manifestations, GBA1 mutations are the highest risk factor for Parkinson’s ...
Manoj Kumar, Ricardo A. Feldman
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Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex [PDF]
JCI Insight, 2023 Tuberous sclerosis complex (TSC) is characterized by multisystem, low-grade neoplasia involving the lung, kidneys, brain, and heart. Lymphangioleiomyomatosis (LAM) is a progressive pulmonary disease affecting almost exclusively women.
A. Astrinidis +23 more
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