Results 41 to 50 of about 8,571 (202)
PLoS ONE, 2016 ObjectiveExcess dietary lipids result in the accumulation of lipid metabolites including ceramides that can attenuate insulin signaling. There is evidence that a botanical extract of Urtica dioica L.
Diana N Obanda +5 more
doaj +1 more source
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]
, 2017 The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio +16 more
core +3 more sources
JCI Insight, 2022 Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been associated with nonsyndromic and syndromic retinitis pigmentosa.
Dominik Lewandowski +21 more
doaj +1 more source
Long-term biopermanence of ceramides, cholesteryl esters, and ether-linked triglycerides with very-long-chain PUFA in the cadmium-damaged testis [PDF]
, 2014 Cadmium is known to harm rat testis by causing the dose-dependent apoptotic or necrotic death of seminiferous epithelium cells. Here we investigated how this affects the lipids with long-chain (C18-C22) and very-long-chain (C24-C32) polyunsaturated fatty
Aveldaño, Marta I. +1 more
core +2 more sources
Role of ceramide in diabetes mellitus: evidence and mechanisms [PDF]
, 2013 Diabetes mellitus is a metabolic disease with multiple complications that causes serious diseases over the years. The condition leads to severe economic consequences and is reaching pandemic level globally.
Alaa Galadari +4 more
core +1 more source
Nature Communications, 2020 Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
Judith Lang +30 more
doaj +1 more source
The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile
Annals of Clinical and Translational Neurology, 2022 Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme
Michelle M. Lee +16 more
doaj +1 more source
Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation [PDF]
, 2006 Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts both as an extracellular ligand for endothelial differentiation gene receptor family and as an intracellular second messenger.
Brancaleone, V +9 more
core +1 more source
Acid ceramidase confers radioresistance to glioblastoma cells
Oncology Reports, 2017 Glioblastoma multiforme (GBM) is the most common primary, intracranial malignancy of the central nervous system. The standard treatment protocol, which involves surgical resection, and concurrent radiation with adjuvant temozolomide (TMZ), still imparts a grim prognosis.
Doan, Ninh B. +9 more
openaire +3 more sources
High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism [PDF]
, 2017 Ovarian cancer is a very severe type of disease with poor prognosis. Treatment of ovarian cancer is challenging because of the lack of tests for early detection and effective therapeutic targets.
Braicu, Elena Ioana +12 more
core +3 more sources