Results 41 to 50 of about 5,986,972 (170)
Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur. [PDF]
J Med Chem, 2019 Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the development of new therapeutics against melanoma and glioblastoma tumors. Despite the strong interest in obtaining structural information, only the structures of the apo-AC enzyme in its zymogen and ...
Dementiev A +9 more
europepmc +4 more sources
Acid ceramidase-1 (ASAH1/aCDase) an important for anticancer drug discovery: a review
Future Journal of Pharmaceutical SciencesBackground Dysregulated sphingolipid metabolism has emerged as a major pathway in multiple human cancers. Sphingolipids are major structural components of cell membranes, playing key roles in maintaining structural integrity, fluidity, and barrier ...
Seemarani M. Pawar +2 more
doaj +2 more sources
Acid ceramidase as a therapeutic target in metastatic prostate cancer[S] [PDF]
Journal of Lipid Research, 2013 Acid ceramidase (AC) catalyzes the hydrolysis of ceramide into sphingosine, in turn a substrate of sphingosine kinases that catalyze its conversion into the mitogenic sphingosine-1-phosphate.
Luz Camacho +14 more
doaj +5 more sources
Markedly perturbed hematopoiesis in acid ceramidase deficient mice
Haematologica, 2015 Acid ceramidase (ACDase) is ubiquitous and catalyzes the degradation of ceramide. ACDase and ceramides have been implicated in many disorders, including cancer, obesity, diabetes, inflammation, and neurodegenerative diseases.[1][1]–[3][2] Deficiencies in ACDase activity lead to Farber disease ...
Shaalee Dworski +8 more
doaj +3 more sources
Sphingolipids and acid ceramidase as therapeutic targets in cancer therapy
Critical Reviews in Oncology/Hematology, 2019 Sphingolipids have been shown to play a key part in cancer cell growth and death and have increasingly become the subject of novel anti-cancer therapies. Acid ceramidase, a sphingolipid enzyme, has an important role in the regulation of apoptosis. In this review we aim to assess the current evidence supporting the role of sphingolipids in cancer and ...
Dale Vimalachandran, Rachael Clifford
exaly +3 more sources
Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors
bioRxivAbstract Oligodendroglioma is genetically defined as a tumor harboring isocitrate dehydrogenase 1 or 2 mutations (IDH1 mut /IDH2 mut ) and 1p/19q co-deletions. Previously, we reported that in IDH1 mut gliomas, D-
Helena Muley +11 more
semanticscholar +3 more sources
Frontiers in Cell and Developmental Biology, 2021 Ceramide is a bioactive signaling lipid involved in the pathogenesis of numerous diseases. It also plays an important role in ischemia reperfusion (IR) injury via activation of inflammatory/oxidative stress-stimulated signaling pathways, resulting in ...
Yuan Jiang +5 more
doaj +1 more source
Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells [PDF]
International Journal of Molecular Sciences, 2021 Mario Costa +2 more
exaly +2 more sources
Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. [PDF]
PLoS ONE, 2017 Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer.
Aiping Bai +5 more
doaj +1 more source
Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration
Cells, 2020 Ceramide and sphingosine are important interconvertible sphingolipid metabolites which govern various signaling pathways related to different aspects of cell survival and senescence. The conversion of ceramide into sphingosine is mediated by ceramidases.
Carolina Duarte +5 more
doaj +1 more source