Molecular Therapy, 2007 Head and neck squamous cell cancers (HNSCC) are particularly aggressive and are resistant to many forms of treatment. Ceramide metabolism has been shown to play an important role in cancer progression and cancer resistance to therapy in many tumor models, including HNSCC.
Elojeimy, Saeed +15 more
openaire +4 more sources
Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur. [PDF]
J Med Chem, 2019 Human acid ceramidase (AC) is a lysosomal cysteine amidase, which has received a great deal of interest in recent years as a potential target for the development of new therapeutics against melanoma and glioblastoma tumors. Despite the strong interest in obtaining structural information, only the structures of the apo-AC enzyme in its zymogen and ...
Dementiev A +9 more
europepmc +4 more sources
Acid ceramidase as a therapeutic target in metastatic prostate cancer[S] [PDF]
Journal of Lipid Research, 2013 Acid ceramidase (AC) catalyzes the hydrolysis of ceramide into sphingosine, in turn a substrate of sphingosine kinases that catalyze its conversion into the mitogenic sphingosine-1-phosphate.
Luz Camacho +14 more
doaj +5 more sources
Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. [PDF]
PLoS ONE, 2017 Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer.
Aiping Bai +5 more
doaj +1 more source
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]
, 2020 CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun +12 more
core +2 more sources
Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells. [PDF]
Int J Mol Sci, 2021 Lai M +9 more
europepmc +2 more sources
Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration
Cells, 2020 Ceramide and sphingosine are important interconvertible sphingolipid metabolites which govern various signaling pathways related to different aspects of cell survival and senescence. The conversion of ceramide into sphingosine is mediated by ceramidases.
Carolina Duarte +5 more
doaj +1 more source
The Reverse Activity of Human Acid Ceramidase [PDF]
Journal of Biological Chemistry, 2003 An overexpression system was recently developed to produce and purify recombinant, human acid ceramidase. In addition to ceramide hydrolysis, the purified enzyme was able to catalyze ceramide synthesis using [14C]lauric acid and sphingosine as substrates.
Nozomu, Okino +5 more
openaire +2 more sources
Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
core +1 more source
Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells [PDF]
, 2017 Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine. This reaction lowers intracellular ceramide levels and concomitantly generates sphingosine used for sphingosine-1-phosphate (
Ganesan, Anand +8 more
core +1 more source