Results 21 to 30 of about 2,521,035 (177)
Acid ceramidase as a therapeutic target in metastatic prostate cancer[S] [PDF]
Journal of Lipid Research, 2013 Acid ceramidase (AC) catalyzes the hydrolysis of ceramide into sphingosine, in turn a substrate of sphingosine kinases that catalyze its conversion into the mitogenic sphingosine-1-phosphate.
Luz Camacho +14 more
doaj +5 more sources
Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency [PDF]
Journal of Inherited Metabolic Disease, 2022 Jeffrey A. Medin +2 more
exaly +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Ceramide is a bioactive signaling lipid involved in the pathogenesis of numerous diseases. It also plays an important role in ischemia reperfusion (IR) injury via activation of inflammatory/oxidative stress-stimulated signaling pathways, resulting in ...
Yuan Jiang +5 more
doaj +1 more source
Acid ceramidase promotes senescent cell survival. [PDF]
Aging (Albany NY), 2021 Cellular senescence is linked to chronic age-related diseases including atherosclerosis, diabetes, and neurodegeneration. Compared to proliferating cells, senescent cells express distinct subsets of proteins. In this study, we used cultured human diploid fibroblasts rendered senescent through replicative exhaustion or ionizing radiation to identify ...
Munk R +13 more
europepmc +3 more sources
Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells [PDF]
Cancer Science, 2021 Toru Ikegami +2 more
exaly +2 more sources
Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells [PDF]
International Journal of Molecular Sciences, 2021 Mario Costa, Michele Lai, Paola Quaranta
exaly +2 more sources
ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS
, 2013 The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I
Stefano Ponzano +5 more
core +6 more sources
Targeting Acid Ceramidase to Attenuate Kidney Fibrosis [PDF]
, 2022 Chronic kidney disease (CKD) affects nearly 1 in 10 Canadians, a condition that in its end-stage has a worse prognosis than most cancers, and results in an annual healthcare cost of $40 billion.
Ki, Seung Hyun
core +1 more source
Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration
Cells, 2020 Ceramide and sphingosine are important interconvertible sphingolipid metabolites which govern various signaling pathways related to different aspects of cell survival and senescence. The conversion of ceramide into sphingosine is mediated by ceramidases.
Carolina Duarte +5 more
doaj +1 more source
The Reverse Activity of Human Acid Ceramidase [PDF]
Journal of Biological Chemistry, 2003 An overexpression system was recently developed to produce and purify recombinant, human acid ceramidase. In addition to ceramide hydrolysis, the purified enzyme was able to catalyze ceramide synthesis using [14C]lauric acid and sphingosine as substrates.
Nozomu, Okino +5 more
openaire +2 more sources