Results 61 to 70 of about 2,521,035 (177)

Ceramidase is involved in metabolic reprogramming of fibroblasts under hypoxia conditions

Frontiers in Physiology
IntroductionPhysiological metabolic reprogramming is a cells strategy to resist/counteract stress to preserve homeostasis. Hypoxia is an important stress stimulus that can promote tissue remodeling and fibrosis, in which alterations in sphingolipid ...
Michela Terlizzi, Emmanuel D’Andria, Emmanuel D’Andria, Chiara Colarusso, Simone Di Caprio, Simone Di Caprio, Anna Falanga, Anna Falanga, Maria Rosaria Lauro, Rosario Salvi, Rosalinda Sorrentino   +10 more
doaj   +1 more source

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, Volume 41, Issue 9, Page 2349-2356, September 2026.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source

Characterization of genes involved in ceramide metabolism in the Pacific oyster (Crassostrea gigas)

BMC Research Notes, 2012
Background The lipid signaling molecule, ceramide, is a key component of the vertebrate stress response, however, there is limited information concerning its role in invertebrate species.
Timmins-Schiffman Emma, Roberts Steven
doaj   +1 more source

Porphyromonas gingivalis‐Derived Phosphoglycerol‐isoC17:0‐Dihydroceramide Reprograms Sphingolipid Metabolism in Human OECM‐1 Oral Squamous Cell Carcinoma Cells

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Dihydroceramide and ceramide sphingolipids suppress proliferation, whereas sphingosine‐1‐phosphate (S‐1‐P) promotes it. The balance between ceramide/S‐1‐P is critically regulated by the ceramide‐hydrolyzing enzyme known as acid ceramidase (aCDase) in oral squamous cell carcinoma (OSCC). Indeed, phosphoglycerol‐isoC17:0‐dihydroceramide (PGDHC), produced
Chiaki Yamada, Anny Ho, Natasha Sanz, Gang Peng, Ruijuan Xu, Cungui Mao, Xue Yuan, Fatemeh Momen‐Heravi, Paul C. Edwards, Frank Nichols, Alexandru Movila   +10 more
wiley   +1 more source

Tamoxifen is a candidate first‐in‐class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells—Unrecognized players in tumorigenesis

Cancer Medicine, 2020
Polyploid giant cancer cells (PGCC) represent a poorly understood, small subpopulation of tumor cells that are increasingly being recognized for their critical role in therapy resistance, metastasis, and cancer recurrence.
Shai White‐Gilbertson, Ping Lu, Christian M. Jones, Stephanie Chiodini, Deborah Hurley, Arabinda Das, Joe R. Delaney, James S. Norris, Christina Voelkel‐Johnson   +8 more
doaj   +1 more source

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

Role of Acid Ceramidase in Resistance to FasL: Therapeutic Approaches Based on Acid Ceramidase Inhibitors and FasL Gene Therapy

Molecular Therapy, 2007
Head and neck squamous cell cancers (HNSCC) are particularly aggressive and are resistant to many forms of treatment. Ceramide metabolism has been shown to play an important role in cancer progression and cancer resistance to therapy in many tumor models, including HNSCC.
Elojeimy, Saeed, Liu, Xiang, Mckillop, John C, El-Zawahry, Ahmed M, Holman, David H, Cheng, Jonathan Y, Meacham, William D, Mahdy, Ayman EM, Saad, Antonio F, Turner, Lorianne S, Cheng, Joseph, A Day, Terrence, Dong, Jian-Yun, Bielawska, Alicja, Hannun, Yusuf A, Norris, James Scott   +15 more
openaire   +2 more sources

Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols

Journal of Lipid Research, 2015
Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids. Previously, we reported on the use of the RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity.
Mireia Casasampere, Luz Camacho, Francesca Cingolani, Josefina Casas, Meritxell Egido-Gabás, José Luís Abad, Carmen Bedia, Ruijuan Xu, Kai Wang, Daniel Canals, Yusuf A. Hannun, Cungui Mao, Gemma Fabrias   +12 more
doaj   +1 more source

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley   +1 more source

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase [PDF]

Journal of Biological Chemistry, 2011
Acid sphingomyelinase (aSMase) generates the bioactive lipid ceramide (Cer) from hydrolysis of sphingomyelin (SM). However, its precise roles in regulating specific sphingolipid-mediated biological processes remain ill defined. Interestingly, the aSMase gene gives rise to two distinct enzymes, lysosomal sphingomyelinase (L-SMase) and secretory ...
Jenkins, Russell W., Clarke, Christopher J., Canals, Daniel, Snider, Ashley J., Gault, Christopher R., Heffernan-Stroud, Linda, Wu, Bill X., Simbari, Fabio, Roddy, Patrick, Kitatani, Kazuyuki, Obeid, Lina M., Hannun, Yusuf A.   +11 more
openaire   +3 more sources