Results 61 to 70 of about 8,571 (202)
Infection and Drug Resistance, 2023 Qian Qi,1,2,* Jiawei Xu,1,2,* Yujiao Wang,3,* Jian Zhang,1 Mingxia Gao,1 Yu Li,4 Liang Dong1,2 1Department of Respiratory, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong ...
Qi Q +6 more
doaj
Chronic glucocorticoid-rich milieu and liver dysfunction [PDF]
, 2016 We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats.
Castro, María Cecilia +7 more
core +6 more sources
The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada +8 more
wiley +1 more source
Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22 [PDF]
, 2012 A substantial proportion of familial colorectal cancer (CRC) is not a consequence of known susceptibility loci, such as mismatch repair (MMR) genes, supporting the existence of additional loci.
Allyson S Templeton +33 more
core +10 more sources
Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization [PDF]
, 2015 Background: Fertilization is a key physiological process for the preservation of the species. Consequently, different mechanisms affecting the sperm and the oocyte have been developed to ensure a successful fertilization. Thus, sperm acrosome reaction is
Avilés Sánchez, Manuel +11 more
core +2 more sources
GLP‐1 agonists and the gut microbiome: A bidirectional relationship
British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath +2 more
wiley +1 more source
On the role of bioactive sphingolipids and their metabolizing enzymes in cancer [PDF]
, 2017 Ceramide is a family of closely related molecules, which are presumed to be in the center of sphingolipid metabolism. Among sphingolipid metabolites, several ceramide subspecies and sphingosine induce apoptosis, cell cycle arrest and death, whereas ...
Ahmed, Dilruba
core +1 more source
Acta Crystallographica Section D, Volume 82, Issue 4, Page 383-396, April 2026.This study reports the first crystal structure of human TANGO2, mutations of which are responsible for TANGO2 deficiency disorder. The crystallographic analysis demonstrates that interactions between heme and TANGO2 are nonspecific, helping to address ongoing questions about the role of TANGO2 as a heme‐trafficking protein.Recently, there has been ...
Dayong Zhou +3 more
wiley +1 more source
Sphingosine 1-phosphate receptors: do they have a therapeutic potential in cardiac fibrosis? [PDF]
, 2017 Sphingosine 1-phosphate (S1P) is a bioactive lipid that is characterized by a peculiar mechanism of action. In fact, S1P, which is produced inside the cell, can act as an intracellular mediator, whereas after its export outside the cell, it can act as ...
Frati, Alessia +4 more
core +2 more sources
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek +7 more
wiley +1 more source