Results 81 to 90 of about 5,986,972 (170)

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Ceramides have garnered considerable attention as pro‐aging bioactive lipids implicated in both metabolic dysfunction and musculoskeletal decline. Among these, C18:0 and C24:1 ceramides may play a role in the pathophysiology of sarcopenia, a key manifestation of age‐related deterioration.
So Jeong Park, Ji Yeon Baek, Shibo Wei, Jin Young Lee, Yuna Lee, Sang‐Hoon Lee, Il‐Young Jang, Hyuk Sakong, Hyun Ju Yoo, Hee‐Won Jung, Eunju Lee, Su Jung Kim, Yunju Jo, Kyunggon Kim, Dongryeol Ryu, Beom‐Jun Kim   +15 more
wiley   +1 more source

Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols

Journal of Lipid Research, 2015
Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids. Previously, we reported on the use of the RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity.
Mireia Casasampere, Luz Camacho, Francesca Cingolani, Josefina Casas, Meritxell Egido-Gabás, José Luís Abad, Carmen Bedia, Ruijuan Xu, Kai Wang, Daniel Canals, Yusuf A. Hannun, Cungui Mao, Gemma Fabrias   +12 more
doaj   +1 more source

Role of Acid Ceramidase in Resistance to FasL: Therapeutic Approaches Based on Acid Ceramidase Inhibitors and FasL Gene Therapy

Molecular Therapy, 2007
Head and neck squamous cell cancers (HNSCC) are particularly aggressive and are resistant to many forms of treatment. Ceramide metabolism has been shown to play an important role in cancer progression and cancer resistance to therapy in many tumor models, including HNSCC.
Elojeimy, Saeed, Liu, Xiang, Mckillop, John C, El-Zawahry, Ahmed M, Holman, David H, Cheng, Jonathan Y, Meacham, William D, Mahdy, Ayman EM, Saad, Antonio F, Turner, Lorianne S, Cheng, Joseph, A Day, Terrence, Dong, Jian-Yun, Bielawska, Alicja, Hannun, Yusuf A, Norris, James Scott   +15 more
openaire   +2 more sources

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase [PDF]

Journal of Biological Chemistry, 2011
Acid sphingomyelinase (aSMase) generates the bioactive lipid ceramide (Cer) from hydrolysis of sphingomyelin (SM). However, its precise roles in regulating specific sphingolipid-mediated biological processes remain ill defined. Interestingly, the aSMase gene gives rise to two distinct enzymes, lysosomal sphingomyelinase (L-SMase) and secretory ...
Jenkins, Russell W., Clarke, Christopher J., Canals, Daniel, Snider, Ashley J., Gault, Christopher R., Heffernan-Stroud, Linda, Wu, Bill X., Simbari, Fabio, Roddy, Patrick, Kitatani, Kazuyuki, Obeid, Lina M., Hannun, Yusuf A.   +11 more
openaire   +3 more sources

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath, Nicole S. L. Chan, Paul Joyce   +2 more
wiley   +1 more source

The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N‐terminal nucleophile (Ntn) hydrolase

Acta Crystallographica Section D, Volume 82, Issue 4, Page 383-396, April 2026.
This study reports the first crystal structure of human TANGO2, mutations of which are responsible for TANGO2 deficiency disorder. The crystallographic analysis demonstrates that interactions between heme and TANGO2 are nonspecific, helping to address ongoing questions about the role of TANGO2 as a heme‐trafficking protein.Recently, there has been ...
Dayong Zhou, Lirong Chen, John Rose, Bi-Cheng Wang   +3 more
wiley   +1 more source

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek, Magda Tumova, Alex Puskasu, Pavol Utekal, Marek Vrbacky, Ladislav Kuchar, Petr Draber, Viktor Bugajev   +7 more
wiley   +1 more source

Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages

Nature Communications
The tumor microenvironment is reprogrammed by cancer cells and participates in all stages of tumor progression. Neutral ceramidase is a key regulator of ceramide, the central intermediate in sphingolipid metabolism. The contribution of neutral ceramidase
Rui Sun, Chao Lei, Zhishan Xu, Xuemei Gu, Liu Huang, Liang Chen, Yi Tan, Min Peng, Kavitha Yaddanapudi, Leah Siskind, Maiying Kong, Robert Mitchell, Jun Yan, Zhongbin Deng   +13 more
doaj   +1 more source

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Science Translational Medicine, 2020
Acid ceramidase inhibition promotes YAP/TAZ degradation to inactivate fibroblasts, decrease matrix stiffness, and reduce fibrosis in mice. Making a case for aCDase inhibition Activation of YAP/TAZ mechanosignaling promotes organ fibrosis.
Sarah Alsamman, S. Christenson, Amy Yu, Nadia M. E. Ayad, M. Mooring, J. Segal, J. Hu, J. Schaub, Steve S. Ho, Vikram Rao, Megan M. Marlow, S. Turner, M. Sedki, L. Pantano, Sarani Ghoshal, D. Ferreira, Hsiao-Yen Ma, Caroline C. Duwaerts, Regina Español‐Suñer, Lan Wei, Benjamin Newcomb, Izolda Mileva, D. Canals, Y. Hannun, R. Chung, Aras N. Mattis, B. Fuchs, A. Tager, Dean Yimlamai, V. Weaver, Alan C. Mullen, D. Sheppard, Jennifer Y. Chen   +32 more
semanticscholar   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source