Results 81 to 90 of about 2,521,035 (177)
Overexpression of human acid ceramidase precursor and variants of the catalytic center in Sf9 cells : Analysis of ceramidase maturation, autocatalytic processing and interaction with Sap-D [PDF]
, 2009 Ceramides are important building blocks of eukaryotic membranes and primarily serve as membrane anchors of GSLs and sphingomyelins. The lysosomal degradation of ceramide is catalyzed by acid ceramidase and requires the interaction with Sap-D in vivo ...
Chien, Chih-Te
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Intestinal neutral ceramidase exacerbates MASH pathogenesis
eGastroenterologyBackground Metabolic dysfunction-associated steatotic liver disease and its more severe manifestation, metabolic dysfunction-associated steatohepatitis (MASH), are intimately linked to genetic factors, gut microbiota and barrier alteration.
Chao Lei +10 more
doaj +1 more source
F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway
Advanced Science, Volume 13, Issue 13, 3 March 2026.In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu +16 more
wiley +1 more source
Polyarticular arthritis and spinal muscular atrophy in acid ceramidase deficiency
, 2016 Survival of motor neuron 1-negative spinal muscular atrophy (SMA) is heterogeneous and remains a diagnostic challenge. The clinical spectrum continues to expand and ∼33 genes have been identified to date.
Mowat, D +7 more
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Dysbiosis in the Pathogenesis of Atopic Dermatitis
The Journal of Dermatology, Volume 53, Issue 3, Page 388-398, March 2026.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation. Recent research highlights cutaneous dysbiosis as a critical factor in its pathogenesis. In this review, we summarize the interplay between the skin microbiota and host immunity, contrasting the homeostatic ...
Hiroki Okamoto, Yuumi Nakamura
wiley +1 more source
Inhibiting Acid Ceramidase with Phenolphthalein Compounds as a Potential Cancer Treatment
, 2022 Cancer is a prevalent issue. The most common current treatments for cancer include radiation therapy and chemotherapy. However, recent developments in cancer treatment have included targeted therapy.
Smith, Sybil
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Advanced Science, Volume 13, Issue 10, 18 February 2026.In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo +19 more
wiley +1 more source
Neural Plasticity, 2014 The lysosomal acid ceramidase, an enzyme known to limit intracellular ceramide accumulation, has been reported to be defective in neurodegenerative disorders. We show here that rat hippocampal slices, preincubated with the acid ceramidase inhibitor (ACI)
Marie-Elaine Laurier-Laurin +4 more
doaj +1 more source
FARBER DISEASE — DISEASE DESCRIPTION WITH CASE REPORTS
Вопросы современной педиатрии, 2014 Farber disease (lipogranulomatosis, OMIM 228000) — is extremely rare autosomal-recessive disorder from group of lysosomal storage disorders, due to deficiency of acid ceramidase activity enzyme.
I. A. Chikova +7 more
doaj +1 more source
새로운 사람 Acid Ceramidase Homologue 유전자에 대한 연구
, 2000 학위논문(박사) - 한국과학기술원 : 생물과학과, 2000.2, [ ix, 107 p. ]Acid ceramidase (EC 3.5.1.23) is a lysosomal enzyme that hydrolyses ceramide to sphingosine and fatty acid.
홍승범, Hong, Seung-Beom
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