Results 71 to 80 of about 8,571 (202)

Stimulation of Acid Ceramidase Activity by Saposin D

Archives of Biochemistry and Biophysics, 1994
Ceramide is ubiquitously present in plasma membranes and plays a pivotal role in metabolism of sphingolipids. In addition, ceramide and its hydrolytic product, sphingosine, may have important roles as second messengers for cell function and survival. Ceramide is hydrolyzed by both acid and alkaline ceramidase. In this investigation, saposin D was found
N, Azuma, J S, O'Brien, H W, Moser, Y, Kishimoto   +3 more
openaire   +2 more sources

Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols

Journal of Lipid Research, 2015
Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids. Previously, we reported on the use of the RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity.
Mireia Casasampere, Luz Camacho, Francesca Cingolani, Josefina Casas, Meritxell Egido-Gabás, José Luís Abad, Carmen Bedia, Ruijuan Xu, Kai Wang, Daniel Canals, Yusuf A. Hannun, Cungui Mao, Gemma Fabrias   +12 more
doaj   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, Volume 13, Issue 13, 3 March 2026.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase [PDF]

Journal of Biological Chemistry, 2011
Acid sphingomyelinase (aSMase) generates the bioactive lipid ceramide (Cer) from hydrolysis of sphingomyelin (SM). However, its precise roles in regulating specific sphingolipid-mediated biological processes remain ill defined. Interestingly, the aSMase gene gives rise to two distinct enzymes, lysosomal sphingomyelinase (L-SMase) and secretory ...
Jenkins, Russell W., Clarke, Christopher J., Canals, Daniel, Snider, Ashley J., Gault, Christopher R., Heffernan-Stroud, Linda, Wu, Bill X., Simbari, Fabio, Roddy, Patrick, Kitatani, Kazuyuki, Obeid, Lina M., Hannun, Yusuf A.   +11 more
openaire   +3 more sources

Characterization of genes involved in ceramide metabolism in the Pacific oyster (Crassostrea gigas)

BMC Research Notes, 2012
Background The lipid signaling molecule, ceramide, is a key component of the vertebrate stress response, however, there is limited information concerning its role in invertebrate species.
Timmins-Schiffman Emma, Roberts Steven
doaj   +1 more source

Tamoxifen is a candidate first‐in‐class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells—Unrecognized players in tumorigenesis

Cancer Medicine, 2020
Polyploid giant cancer cells (PGCC) represent a poorly understood, small subpopulation of tumor cells that are increasingly being recognized for their critical role in therapy resistance, metastasis, and cancer recurrence.
Shai White‐Gilbertson, Ping Lu, Christian M. Jones, Stephanie Chiodini, Deborah Hurley, Arabinda Das, Joe R. Delaney, James S. Norris, Christina Voelkel‐Johnson   +8 more
doaj   +1 more source

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation [PDF]

, 2017
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the
A Deshmukh, Albert Hofman, Albert Sun, Albert V Smith, Alex P Reiner, Alexander Teumer, Alexandre Pereira, Alfredo J Mansur, Alvaro Alonso, Anders Hamsten, Andre G Uitterlinden, Andrea R V R Horimoto, Andrew P Morris, Annette Peters, AP Boyle, Archie Campbell, Bastiaan Geelhoed, Blair H Smith, Bradford B Worrall, Bruce M Psaty, Bruno H Stricker, Carolina Roselli, Caroline Hayward, Cecilia M Lindgren, Charles Kooperberg, Christian Shaffer, Christine M Albert, Christopher D Anderson, Christopher Newton-Cheh, CJ Hoggart, CJ Willer, Claudia Schurmann, CT January, D Welter, Dan E Arking, Dan M Roden, Daniel I Chasman, Daniel J Rader, David Conen, David Porteous, David R Van Wagoner, Dawood Darbar, Derek Klarin, DF Gudbjartsson, DF Gudbjartsson, DF Seals, DM Lloyd-Jones, E Eden, Efthymia Vlachopoulou, EJ Benjamin, Elsayed Z Soliman, Emelia J Benjamin, Eric Boerwinkle, Erik Ingelsson, Erwin B Bottinger, F Dudbridge, Farid Radmanesh, G Laumet, Ganesh Chauhan, Graciela Delgado, Guillaume Paré, H Holm, Henry J Lin, Honghuang Lin, I Pe'er, Ian Ford, Ilkka Seppälä, Ingrid E Christophersen, J Gustav Smith, J Wouter Jukema, J Yang, Jan Heeringa, Jared W Magnani, Jari Laurikka, Jeffrey Haessler, Jemma C Hopewell, Jennifer A Brody, Jennifer Huffman, Jennifer Kriebel, Jerome I Rotter, Jie Huang, Jie Yao, John Barnard, Jonathan D Smith, Jonathan Rosand, Jorge A Wong, Jose E Krieger, Joshua C Bis, Joshua C Denny, Joylene E Siland, Juha Sinisalo, Jussi Hernesniemi, Karl-Heinz Jöckel, Kathryn L Lunetta, Kent D Taylor, Kjell Nikus, Lars Lannfelt, Lars Lind, LD Ward, Lenore J Launer, Leo-Pekka Lyytikäinen, Lewin Eisele, Lin Y Chen, Lorenz Risch, Lu-Chen Weng, Lynne J Hocking, M Arnold, M Benjamin Shoemaker, Maartje N Niemeijer, Man Li, Marco Perez, Marcus Dörr, Marcus E Kleber, Marina Arendt, Marja-Liisa Lokki, Marju Orho-Melander, Mark Chaffin, Markku Eskola, Martin Dichgans, Martina Müller-Nurasyid, Melanie Waldenberger, MF Sinner, Michiaki Kubo, Michiel Rienstra, Mika Kähönen, Mina K Chung, Molong Li, Moritz F Sinner, MR Nelson, Nancy L Pedersen, Natalia Rost, Nathan A Bihlmeyer, Nathan R Tucker, Niek Verweij, Nona Sotoodehnia, Olle Melander, Oscar H Franco, P Cejudo-Martin, P Weeke, Patrick T Ellinor, Patrik K Magnusson, Paul L Huang, Paul M Ridker, PC Sham, Peter Almgren, Peter E Weeke, Peter Lichtner, Peter W Macfarlane, Pim van der Harst, PT Ellinor, PT Ellinor, Qiong Yang, R Malik, Rainer Malik, Rajat Deo, RJ Pruim, Roopinder K Sandhu, Ruth J F Loos, S Kuriyama, S Lee, S Purcell, Sandosh Padmanabhan, Sebastian Clauss, Sekar Kathiresan, Seung Hoan Choi, Siegfried Perz, Siew-Kee Low, SS Chugh, ST Sherry, Stefan Gustafsson, Stefan Kääb, Stefan Weiss, Stefanie Aeschbacher, Stefanie Heilmann-Heimbach, Stella Trompet, Stephan B Felix, Stephanie Debette, Steven A Lubitz, Stuart A Scott, Susan R Heckbert, Svati H Shah, Sébastien Thériault, Tamara B Harris, Terho Lehtimäki, TH Pers, TH Pers, Toshihiro Tanaka, Traci M Bartz, Uwe Völker, Vilmundur Gudnason, Winfried März, Xiaoyan Yin, Xiuqing Guo, Y Benjamini, Yanick P Hagemeijer, Yii-Der Ida Chen, Yingchang Lu, Yoichiro Kamatani   +197 more
core   +9 more sources

Dysbiosis in the Pathogenesis of Atopic Dermatitis

The Journal of Dermatology, Volume 53, Issue 3, Page 388-398, March 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation. Recent research highlights cutaneous dysbiosis as a critical factor in its pathogenesis. In this review, we summarize the interplay between the skin microbiota and host immunity, contrasting the homeostatic ...
Hiroki Okamoto, Yuumi Nakamura
wiley   +1 more source

Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis [PDF]

, 2019
Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to ...
Becker, Katrin A., Ebel, Jana-Fabienne, Hose, Matthias [u.v.m.], Japtok, Lukasz, Klopfleisch, Robert, Meiners, Jana, Palmieri, Vittoria, Schumacher, Fabian, Yusuf, Ayan Mohamud, Zöller, Julia   +9 more
core   +1 more source

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, Volume 13, Issue 10, 18 February 2026.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source