Results 101 to 110 of about 8,571 (202)
Neural Plasticity, 2014 The lysosomal acid ceramidase, an enzyme known to limit intracellular ceramide accumulation, has been reported to be defective in neurodegenerative disorders. We show here that rat hippocampal slices, preincubated with the acid ceramidase inhibitor (ACI)
Marie-Elaine Laurier-Laurin +4 more
doaj +1 more source
Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]
, 2019 Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra +3 more
core +1 more source
Topical Live and Heat‐Killed Probiotics for Photoaging Prevention: A Meta‐Analysis
Dermatology Research and Practice, Volume 2026, Issue 1, 2026.Background The skin microbiome plays a crucial role in maintaining healthy skin, and imbalances in this microbial community, often caused by aging and environmental factors like UV radiation, are linked to photoaging. Topical probiotics may help prevent it.
Marina Rimadhani +5 more
wiley +1 more source
Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1 [PDF]
, 2014 Humans and yeast possess alkaline ceramidases located in the early secretory pathway. Single deletions of the highly homologous yeast alkaline ceramidases YPC1 and YDC1 have very little genetic interactions or phenotypes.
Cerantola, Vanessa +7 more
core +1 more source
Secretory Acid Sphingomyelinase in Children and Adolescents With Type 1 Diabetes
Journal of Diabetes Research, Volume 2026, Issue 1, 2026.Introduction The activity of acid sphingomyelinase (ASMase), a key enzyme in sphingolipid metabolism, has been found to be increased in a variety of human diseases. Studies conducted on animal and cellular models showed that sphingolipids and ASMase play a central role in the pathogenesis of type 1 diabetes (T1D) and T1D‐related vascular damage ...
Chiara Mameli +13 more
wiley +1 more source
The steady-state level of plasma membrane ceramide is regulated by neutral sphingomyelinase 2
Journal of Lipid ResearchDuring the last 30 years, an increasing number of cellular functions have been reported to be regulated by the lipid ceramide. The diversity in the ceramide structure, leading to tens of ceramide species and the discrete distribution based on subcellular
Anne G. Ostermeyer-Fay +6 more
doaj +1 more source
Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease
Frontiers in Neurology, 2019 Mitochondrial dysfunction has been recognized as a key player in neurodegenerative diseases, including Alzheimer's disease (AD) and Niemann–Pick type C (NPC) disease.
Sandra Torres +7 more
doaj +1 more source
Autophagy in the light of sphingolipid metabolism [PDF]
, 2015 Maintenance of cellular homeostasis requires tight and coordinated control of numerous metabolic pathways, which are governed by interconnected networks of signaling pathways and energy-sensing regulators.
Færgeman, Nils J. +2 more
core +2 more sources
C26-Ceramide as highly sensitive biomarker for the diagnosis of Farber Disease
Scientific Reports, 2017 Farber disease (FD) is a rare autosomal recessive disease caused by mutations in the acid ceramidase gene (ASAH1). Low ceramidase activity results in the accumulation of fatty substances, mainly ceramides.
Claudia Cozma +9 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2019 As structural membrane components and signaling effector molecules sphingolipids influence a plethora of host cell functions, and by doing so also the replication of viruses.
Anika Grafen +6 more
doaj +1 more source