Results 101 to 110 of about 2,521,035 (177)

Acid Ceramidase in Melanoma [PDF]

Journal of Biological Chemistry, 2016
Natalia Realini, Francesca Palese, Daniela Pizzirani, Silvia Pontis, Abdul Basit, Anders Bach, Anand Ganesan, Daniele Piomelli   +7 more
openaire   +1 more source

Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet β-cells [PDF]

, 2009
Ceramidase hydrolyzes ceramide and produces sphingosine as a substrate of sphingosine kinase (SPHK), which transforms sphingosine to sphingosine-1-phosphate. It has been reported that cytokines elicit SPHK activation in rat β-cells.
Liu, Chao, Liao, Duan-fang, Jin, Junfei, Shan, Xiaohong, Lu, Yibing, Xu, Jiarong, Zhu, Qun, Miao, Heng, You, Na   +8 more
core   +1 more source

Beware of N-Benzoyloxybenzamides

Molecules
Following a High-Throughput Screening campaign to discover inhibitors of acid ceramidase, we report the novel and extremely potent covalent inhibitor, 1.
Jonathan Cubitt, Mari Davies, Ross Riseley, Gabrielle Evans, Sian E. Gardiner, Benson M. Kariuki, Simon E. Ward, Emyr Lloyd-Evans, Helen Waller-Evans, D. Heulyn Jones   +9 more
doaj   +1 more source

Acid ceramidase inhibition: a novel target for cancer therapy

, 2008
During the last decade, sphingolipid deregulation, namely the balance between the pro-apoptotic molecule ceramide and the anti-apoptotic sphingolipid sphingosine-1- phosphate, has emerged as an important factor in cancer pathology and resistance to ...
Liu, X, Szulc, Z, Tavassoli, Mahvash, Szulc, Zdzislaw, Mahdy, Ayman E M, Zeidan, Y H, Holman, David H, Mahdy, A E M, Holman, D H, Rubinchik, Semyon, Liu, Xiang, Dong, J Y, Guo, G W, Tavassoli, M, El-Zawahry, A M, Rubinchik, S, Elojeimy, Saeed, Turner, Lorianne S, Bielawska, Alicja, Hannun, Y A, Turner, L S, Elojeimy, S, Dong, Jian-Yun, Bielawski, J, Hannun, Yusuf A, Norris, J S, El-Zawahry, Ahmed M, Guo, Gui-wen, Zeidan, Youssef H, Bielawski, Jacek, Keane, Thomas E, Norris, James S, Bielawska, A, Keane, T E   +33 more
core   +1 more source

Systemic ceramide accumulation leads to severe and varied pathological consequences

EMBO Molecular Medicine, 2013
Farber disease (FD) is a severe inherited disorder of lipid metabolism characterized by deficient lysosomal acid ceramidase (ACDase) activity, resulting in ceramide accumulation. Ceramide and metabolites have roles in cell apoptosis and proliferation. We
Abdulfatah M. Alayoubi, James C. M. Wang, Bryan C. Y. Au, Stéphane Carpentier, Virginie Garcia, Shaalee Dworski, Samah El‐Ghamrasni, Kevin N. Kirouac, Mathilde J. Exertier, Zi Jian Xiong, Gilbert G. Privé, Calogera M. Simonaro, Josefina Casas, Gemma Fabrias, Edward H. Schuchman, Patricia V. Turner, Razqallah Hakem, Thierry Levade, Jeffrey A. Medin   +18 more
doaj   +1 more source

Farber disease: understanding a fatal childhood disorder and dissecting ceramide biology

EMBO Molecular Medicine, 2013
See related article in EMBO Molecular Medicine http://dx.doi.org/10.1002/emmm ...
Mark S. Sands
doaj   +1 more source

Inhibiting Acid Ceramidase with Phenolphthalein Compounds as a Potential Cancer Treatment

, 2023
Cancer is a prevalent issue. The most common current treatments for cancer include radiation therapy and chemotherapy. However, recent developments in cancer treatment have included targeted therapy.
Smith, Sybil
core  

Acid Ceramidase [PDF]

, 2020
openaire   +1 more source

Acid Ceramidase Deficiency

Background and ObjectivesSpinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME) due to acid ceramidase deficiency is a rare disorder, allelic with Farber disease, resulting from recessive ASAH1 variants. Patients present in early childhood with muscle weakness due to anterior horn degeneration and/or progressive drug-resistant myoclonic ...
Cuinat, Silvestre, Rollier, Paul, Grand, Katheryn, Sanchez-Lara, Pedro, Allen-Sharpley, Michelle, Levade, Thierry, Vanier, Marie, Lion Francois, Laurence, Chemaly, Nicole, de Lattre, Capucine, Moreau, Camille, Paquot, Adrien, Beghyn, Terence, de Masfrand, Servane, Bézieau, Stéphane, Mercier, Sandra, Boespflug-Tanguy, Odile   +16 more
openaire   +1 more source

FFAs induce ceramidase protein expression in a dose dependent manner but do not increase ceramidase activity in adipocytes.

, 2016
Fully differentiated 3T3-L1 adipocytes were incubated with indicated doses of palmitate for 72 hours and (A) cell extracts were examined for acid ceramidase and neutral ceramidase expression.
Peng Zhao (128233), William T. Cefalu (380240), Jacqueline M. Stephens (297020), David Ribnicky (380239), Diana N. Obanda (2551765), Allison J. Richard (575937)   +5 more
core   +1 more source