Results 111 to 120 of about 8,571 (202)

Human Acid Ceramidase [PDF]

Journal of Biological Chemistry, 2001
Klaus Ferlinz, Guido Kopal, Katussevani Bernardo, Thomas Linke, Julia Bär, Bernadette Breiden, Ulrich Neumann, Florian Lang, Edward H. Schuchman, Konrad Sandhoff   +9 more
openaire   +1 more source

FARBER DISEASE — DISEASE DESCRIPTION WITH CASE REPORTS

Вопросы современной педиатрии, 2014
Farber disease (lipogranulomatosis, OMIM 228000) — is extremely rare autosomal-recessive disorder from group of lysosomal storage disorders, due to deficiency of acid ceramidase activity enzyme.
I. A. Chikova, N. V. Buchinskaya, М. М. Kostik, V. V. Avramenko, O. L. Krasnogorskaya, R. A. Nasirov, T. Levade, V. G. Chasnyk   +7 more
doaj   +1 more source

A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease

Journal of Lipid Research, 2010
Acid ceramidase (aCDase) is one of several enzymes responsible for ceramide degradation within mammalian cells. As such, aCDase regulates the intracellular levels of the bioactive lipid ceramide.
Carmen Bedia, Luz Camacho, José Luís Abad, Gemma Fabriàs, Thierry Levade   +4 more
doaj   +1 more source

Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues

Journal of Lipids, 2011
The lipid-signalling molecule ceramide is known to induce apoptosis in a variety of cell types. Inhibition of the lysosomal acid ceramidase can increase cellular ceramide levels and thus induce apoptosis. Indeed, inhibitors of acid ceramidase have been reported to induce cell death and to display potentiating effects to classical radio- or chemo ...
Proksch, Denny, Klein, Jan Jasper, Arenz, Christoph   +2 more
openaire   +2 more sources

Ceramide generation as a novel biological mechanism for chemo-preventive and cytotoxic effects of hesperidin on HT-144 melanoma cells

Beni-Suef University Journal of Basic and Applied Sciences, 2018
Introduction: Hesperidin and its aglycone, hesperetin are abundant natural flavonoid in Citrus and known for their anti-neoplastic and pro-apoptotic properties.
Mahdi Mashhadi Akbar Boojar, Masoud Mashhadi Akbar Boojar, Sepide Golmohammad, Mojtaba Nikkhah Yazdi   +3 more
doaj   +1 more source

Genetic Variation in Acid Ceramidase Predicts Non-completion of an Exercise Intervention

Frontiers in Physiology, 2018
Genetic variation is associated with a number of lifestyle behaviours; it may be associated with adherence and individual responses to exercise training. We tested single nucleotide polymorphisms (SNPs) in the acid ceramidase gene (ASAH1) for association
Lauren S. Lewis, Kim M. Huffman, Kim M. Huffman, Ira J. Smith, Mark P. Donahue, Cris A. Slentz, Joseph A. Houmard, Monica J. Hubal, Eric P. Hoffman, Elizabeth R. Hauser, Elizabeth R. Hauser, Ilene C. Siegler, William E. Kraus, William E. Kraus   +13 more
doaj   +1 more source

Acid Ceramidase in Melanoma [PDF]

Journal of Biological Chemistry, 2016
Natalia Realini, Francesca Palese, Daniela Pizzirani, Silvia Pontis, Abdul Basit, Anders Bach, Anand Ganesan, Daniele Piomelli   +7 more
openaire   +1 more source

Beware of N-Benzoyloxybenzamides

Molecules
Following a High-Throughput Screening campaign to discover inhibitors of acid ceramidase, we report the novel and extremely potent covalent inhibitor, 1.
Jonathan Cubitt, Mari Davies, Ross Riseley, Gabrielle Evans, Sian E. Gardiner, Benson M. Kariuki, Simon E. Ward, Emyr Lloyd-Evans, Helen Waller-Evans, D. Heulyn Jones   +9 more
doaj   +1 more source

An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. [PDF]

, 2019
Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for ...
Cheang, Rachel T, Chen, Tzu-Chieh, Fitch, Mark D, Gray, Nora E, Hellerstein, Marc K, Kanamaluru, Deepthi, Lee, Justin Y, Lee, Rebecca A, Tan, Jenna H, Tsai, Sam L, Wang, Jen-Chywan, Yiv, Nicholas   +11 more
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Interfacial Regulation of Acid Ceramidase Activity [PDF]

Journal of Biological Chemistry, 2001
Thomas Linke, Gundo Wilkening, Farsaneh Sadeghlar, Heidi Mozcall, Katussevani Bernardo, Edward Schuchman, Konrad Sandhoff   +6 more
openaire   +1 more source