Results 111 to 120 of about 5,986,972 (170)

Acid Ceramidase in Melanoma [PDF]

Journal of Biological Chemistry, 2016
Natalia Realini, Francesca Palese, Daniela Pizzirani, Silvia Pontis, Abdul Basit, Anders Bach, Anand Ganesan, Daniele Piomelli   +7 more
openaire   +1 more source

Beware of N-Benzoyloxybenzamides

Molecules
Following a High-Throughput Screening campaign to discover inhibitors of acid ceramidase, we report the novel and extremely potent covalent inhibitor, 1.
Jonathan Cubitt, Mari Davies, Ross Riseley, Gabrielle Evans, Sian E. Gardiner, Benson M. Kariuki, Simon E. Ward, Emyr Lloyd-Evans, Helen Waller-Evans, D. Heulyn Jones   +9 more
doaj   +1 more source

Systemic ceramide accumulation leads to severe and varied pathological consequences

EMBO Molecular Medicine, 2013
Farber disease (FD) is a severe inherited disorder of lipid metabolism characterized by deficient lysosomal acid ceramidase (ACDase) activity, resulting in ceramide accumulation. Ceramide and metabolites have roles in cell apoptosis and proliferation. We
Abdulfatah M. Alayoubi, James C. M. Wang, Bryan C. Y. Au, Stéphane Carpentier, Virginie Garcia, Shaalee Dworski, Samah El‐Ghamrasni, Kevin N. Kirouac, Mathilde J. Exertier, Zi Jian Xiong, Gilbert G. Privé, Calogera M. Simonaro, Josefina Casas, Gemma Fabrias, Edward H. Schuchman, Patricia V. Turner, Razqallah Hakem, Thierry Levade, Jeffrey A. Medin   +18 more
doaj   +1 more source

Acid Ceramidase [PDF]

, 2020
openaire   +1 more source

P81 | AN IN VITRO CYTOTOXIC, PROAPOPTOTIC AND ANTITUMOR ACTIVITY ASSESSMENT FOR CERAMIDASE INHIBITORS ON HUMAN LARYNGEAL CANCER CELLS

European Journal of Histochemistry
Laryngeal cancer is diagnosed approximately 20% of head and neck cancers worldwide1. Among the potential sphingolipid-based treatment methods for the treatment of these fatal cancers2 acid ceramidase inhibition is indicated as a beneficial treatment ...
doaj   +1 more source

Interfacial Regulation of Acid Ceramidase Activity [PDF]

Journal of Biological Chemistry, 2001
Thomas Linke, Gundo Wilkening, Farsaneh Sadeghlar, Heidi Mozcall, Katussevani Bernardo, Edward Schuchman, Konrad Sandhoff   +6 more
openaire   +1 more source

Decreased Sphingosine Due to Down-Regulation of Acid Ceramidase Expression in Airway of Bronchiectasis Patients: A Potential Contributor to Pseudomonas aeruginosa Infection. [PDF]

Infect Drug Resist, 2023
Qi Q, Xu J, Wang Y, Zhang J, Gao M, Li Y, Dong L.   +6 more
europepmc   +1 more source

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis. [PDF]

Elife, 2022
Günther A, Hose M, Abberger H, Schumacher F, Veith Y, Kleuser B, Matuschewski K, Lang KS, Gulbins E, Buer J, Westendorf AM, Hansen W.   +11 more
europepmc   +1 more source

Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia. [PDF]

Blood Neoplasia
Ung J, Tan SF, Shaw JJP, Taori M, Deddens TM, Venancio G, Montgomery MM, Hagen JT, Aruleba RT, Golla UR, Sharma A, Paudel BB, Lee I, Ramamoorthy B, Janes KA, Garrett-Bakelman F, Cabot MC, Fisher-Wellman KH, Fox TE, Claxton DF, Chalfant CE, Feith DJ, Loughran TP.   +22 more
europepmc   +1 more source

Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells. [PDF]

Cancer Sci, 2021
Taniai T, Shirai Y, Shimada Y, Hamura R, Yanagaki M, Takada N, Horiuchi T, Haruki K, Furukawa K, Uwagawa T, Tsuboi K, Okamoto Y, Shimada S, Tanaka S, Ohashi T, Ikegami T.   +15 more
europepmc   +1 more source