Results 131 to 140 of about 8,571 (202)

Recent advances in pharmaceutical sciences V [PDF]

, 2015
Reproducció del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=249This E-book is the fifth volume of a series that compiles contributions from different areas of the multidisciplinary field of Pharmaceutical Sciences. The E-book consists
Muñoz-Torrero López-Ibarra, Diego, Palazón Barandela, Javier, Vinardell Martínez-Hidalgo, Ma. Pilar   +2 more
core  

Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia. [PDF]

Cancers (Basel), 2023
Ung J, Tan SF, Fox TE, Shaw JJP, Taori M, Horton BJ, Golla U, Sharma A, Szulc ZM, Wang HG, Chalfant CE, Cabot MC, Claxton DF, Loughran TP, Feith DJ.   +14 more
europepmc   +1 more source

Acid ceramidase-1 (ASAH1/aCDase) an important for anticancer drug discovery: a review

Future Journal of Pharmaceutical Sciences
Background Dysregulated sphingolipid metabolism has emerged as a major pathway in multiple human cancers. Sphingolipids are major structural components of cell membranes, playing key roles in maintaining structural integrity, fluidity, and barrier ...
Seemarani M. Pawar, Trupti Chitre, Prasad Dandawate   +2 more
doaj   +1 more source

Acid ceramidase involved in pathogenic cascade leading to accumulation of α-synuclein in iPSC model of GBA1-associated Parkinson's disease. [PDF]

Hum Mol Genet, 2023
Kumar M, Srikanth MP, Deleidi M, Hallett PJ, Isacson O, Feldman RA.   +5 more
europepmc   +1 more source

Skin inflammation and impaired adipogenesis in a mouse model of acid ceramidase deficiency. [PDF]

J Inherit Metab Dis, 2022
Rybova J, Kuchar L, Sikora J, McKillop WM, Medin JA.   +4 more
europepmc   +1 more source

Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis. [PDF]

Mol Med, 2022
Xiao J, Zeng W, Zhang P, Zhou Y, Fang Q.
europepmc   +1 more source

Decreased Sphingosine Due to Down-Regulation of Acid Ceramidase Expression in Airway of Bronchiectasis Patients: A Potential Contributor to Pseudomonas aeruginosa Infection. [PDF]

Infect Drug Resist, 2023
Qi Q, Xu J, Wang Y, Zhang J, Gao M, Li Y, Dong L.   +6 more
europepmc   +1 more source

Human acid ceramidase: processing, glycosylation, and lysosomal targeting.

The Journal of biological chemistry, 2001
The biosynthesis of human acid ceramidase (hAC) starts with the expression of a single precursor polypeptide of approximately 53-55 kDa, which is subsequently processed to the mature, heterodimeric enzyme (40 + 13 kDa) in the endosomes/lysosomes. Secretion of hAC by either fibroblasts or acid ceramidase cDNA-transfected COS cells is extraordinarily low.
K, Ferlinz, G, Kopal, K, Bernardo, T, Linke, J, Bar, B, Breiden, U, Neumann, F, Lang, E H, Schuchman, K, Sandhoff   +9 more
openaire   +1 more source

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis. [PDF]

Elife, 2022
Günther A, Hose M, Abberger H, Schumacher F, Veith Y, Kleuser B, Matuschewski K, Lang KS, Gulbins E, Buer J, Westendorf AM, Hansen W.   +11 more
europepmc   +1 more source

Acid Ceramidase Deficiency: Bridging Gaps between Clinical Presentation, Mouse Models, and Future Therapeutic Interventions. [PDF]

Biomolecules, 2023
Kleynerman A, Rybova J, Faber ML, McKillop WM, Levade T, Medin JA.   +5 more
europepmc   +1 more source