Results 121 to 130 of about 5,986,972 (170)

Exploration of a Class of Aryl Imidazolyl Ureas As Potent Acid Ceramidase Inhibitors for the Treatment of Fibrotic Diseases. [PDF]

ACS Omega
Beresis R, Prathigudupu V, Cable C, Yu A, Adler M, Ramamoorthi R, Yeon SK, Gordan JD, Sharma S, DeGrado WF, Zaro B, Chen JY, Jo H.   +12 more
europepmc   +1 more source

Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections. [PDF]

Infect Immun, 2021
Becker KA, Verhaegh R, Verhasselt HL, Keitsch S, Soddemann M, Wilker B, Wilson GC, Buer J, Ahmad SA, Edwards MJ, Gulbins E.   +10 more
europepmc   +1 more source

Publisher Correction: Acid ceramidase controls apoptosis and increases autophagy in human melanoma cells treated with doxorubicin. [PDF]

Sci Rep, 2021
Lai M, Amato R, La Rocca V, Bilgin M, Freer G, Spezia P, Quaranta P, Piomelli D, Pistello M.   +8 more
europepmc   +1 more source

Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis. [PDF]

J Biol Chem, 2021
Gardner AI, Wu Y, Verhaegh R, Liu Y, Wilker B, Soddemann M, Keitsch S, Edwards MJ, Haq IJ, Kamler M, Becker KA, Brodlie M, Gulbins E.   +12 more
europepmc   +1 more source

Clinical features and genetics in non-5q spinal muscular atrophy caused by acid ceramidase deficiency. [PDF]

J Med Life, 2021
Axente M, Shelby ES, Mirea A, Sporea C, Badina M, Padure L, Ion DA.   +6 more
europepmc   +1 more source

Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis. [PDF]

Am J Respir Crit Care Med, 2020
Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M.   +18 more
europepmc   +1 more source

Hematopoietic stem cell transplantation leads to biochemical and functional correction in two mouse models of acid ceramidase deficiency. [PDF]

Mol Ther
Rybova J, Sundararajan T, Kuchar L, Dlugi TA, Ruzicka P, McKillop WM, Medin JA.   +6 more
europepmc   +1 more source

Acid ceramidase expression reduces IFNγ secretion by mouse CD4⁺ T cells and is crucial for maintaining B-cell numbers in mice. [PDF]

Front Immunol
Mandasari P, Hollmann C, Zaidi RH, Löw S, Schrama J, Wigger D, Schumacher F, Kleuser B, Beyersdorf N.   +8 more
europepmc   +1 more source

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Acid Ceramidase: A Novel Therapeutic Target in Cancer

Current Topics in Medicinal Chemistry, 2019
Sphingolipids are important constituents of the eukaryotic cell membrane which govern various signaling pathways related to different aspects of cell survival. Ceramide and Sphingosine are interconvertible sphingolipid metabolites, out of which Ceramide is pro-apoptotic and sphingosine is anti-apoptotic in nature.
Harikumar Kb
exaly   +3 more sources