Results 121 to 130 of about 8,571 (202)

Secretoma do fungo biocontrolador Metarhizium anisopliae relacionado à infecção do carrapato bovino Rhipicephalus microplus [PDF]

, 2016
O controle biológico é considerado uma alternativa natural e ecológica para o controle de pragas, evitando os problemas causados pela utilização de agentes químicos.
Scherer, Karine
core  

P81 | AN IN VITRO CYTOTOXIC, PROAPOPTOTIC AND ANTITUMOR ACTIVITY ASSESSMENT FOR CERAMIDASE INHIBITORS ON HUMAN LARYNGEAL CANCER CELLS

European Journal of Histochemistry
Laryngeal cancer is diagnosed approximately 20% of head and neck cancers worldwide1. Among the potential sphingolipid-based treatment methods for the treatment of these fatal cancers2 acid ceramidase inhibition is indicated as a beneficial treatment ...
doaj   +1 more source

Farber disease: Understanding a fatal childhood disorder and dissecting ceramide biology [PDF]

, 2013
Farber S, Mark S. Sands
core   +2 more sources

Acid Ceramidase [PDF]

, 2020
openaire   +1 more source

Upregulation of acid ceramidase contributes to tumor progression in tuberous sclerosis complex. [PDF]

JCI Insight, 2023
Astrinidis A, Li C, Zhang EY, Zhao X, Zhao S, Guo M, Olatoke T, Mattam U, Huang R, Zhang AG, Pitstick L, Kopras EJ, Gupta N, Jandarov R, Smith EP, Fugate E, Lindquist D, Markiewski MM, Karbowniczek M, Wikenheiser-Brokamp KA, Setchell KDR, McCormack FX, Xu Y, Yu JJ.   +23 more
europepmc   +1 more source

Acid Ceramidase Deficiency

Background and ObjectivesSpinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME) due to acid ceramidase deficiency is a rare disorder, allelic with Farber disease, resulting from recessive ASAH1 variants. Patients present in early childhood with muscle weakness due to anterior horn degeneration and/or progressive drug-resistant myoclonic ...
Cuinat, Silvestre, Rollier, Paul, Grand, Katheryn, Sanchez-Lara, Pedro, Allen-Sharpley, Michelle, Levade, Thierry, Vanier, Marie, Lion Francois, Laurence, Chemaly, Nicole, de Lattre, Capucine, Moreau, Camille, Paquot, Adrien, Beghyn, Terence, de Masfrand, Servane, Bézieau, Stéphane, Mercier, Sandra, Boespflug-Tanguy, Odile   +16 more
openaire   +1 more source

Inhibitory effect of Porphyromonas gingivalis-derived phosphoethanolamine dihydroceramide on acid ceramidase expression in oral squamous cells. [PDF]

J Cell Mol Med, 2023
Yamada C, Ho A, Nusbaum A, Xu R, Davey ME, Nichols F, Mao C, Movila A.   +7 more
europepmc   +1 more source

Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites. [PDF]

, 2019
Age and Alzheimer's disease (AD) share some common features such as cognitive impairments, memory loss, metabolic disturbances, bioenergetic deficits, and inflammation.
Brewer, Gregory J, Dong, Yue
core  

Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling [PDF]

, 2014
Adiponectin is an adipocyte-secreted adipokine with pleiotropic actions. Clinical evidence has shown that serum adiponectin levels are increased and that adiponectin can protect pancreatic beta cells against apoptosis, which suggests that adiponectin may
Cheng, X, Da, Y, Huang, B, Li, M, Peng, M, Wang, D, Xu, A, Xue, Z, Yao, Z, Zhang, N, Zhang, R   +10 more
core   +1 more source

Spinal muscular atrophy-like phenotype in a mouse model of acid ceramidase deficiency. [PDF]

Commun Biol, 2023
Nagree MS, Rybova J, Kleynerman A, Ahrenhoerster CJ, Saville JT, Xu T, Bachochin M, McKillop WM, Lawlor MW, Pshezhetsky AV, Isaeva O, Budde MD, Fuller M, Medin JA.   +13 more
europepmc   +1 more source