Results 21 to 30 of about 6,648 (196)
<i>Porphyromonas gingivalis</i>-Derived Phosphoglycerol-isoC17:0-Dihydroceramide Reprograms Sphingolipid Metabolism in Human OECM-1 Oral Squamous Cell Carcinoma Cells. [PDF]
FASEB BioadvDihydroceramide and ceramide sphingolipids suppress proliferation, whereas sphingosine‐1‐phosphate (S‐1‐P) promotes it. The balance between ceramide/S‐1‐P is critically regulated by the ceramide‐hydrolyzing enzyme known as acid ceramidase (aCDase) in oral squamous cell carcinoma (OSCC). Indeed, phosphoglycerol‐isoC17:0‐dihydroceramide (PGDHC), produced
Yamada C +10 more
europepmc +2 more sources
Loss of Acid Ceramidase in Myeloid Cells Protects From Chronic Colitis in IL10‐Deficient Mice [PDF]
FASEB JAcid ceramidase converts ceramide to sphingosine which can then be converted to sphingosine‐1‐phosphate, a bioactive lipid involved in inflammation. Loss of acid ceramidase in myeloid cells protects from chronic colitis by reducing pro‐inflammatory markers, increasing ceramides, and reducing effector immune cells in the colon.
Espinoza K +13 more
europepmc +2 more sources
The Acid Ceramidase Is a SARS-CoV-2 Host Factor
Cells, 2022 SARS-CoV-2 variants such as the delta or omicron variants, with higher transmission rates, accelerated the global COVID-19 pandemic. Thus, novel therapeutic strategies need to be deployed.
Nina Geiger +14 more
doaj +1 more source
Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization. [PDF]
J PatholAbstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Takada M +8 more
europepmc +2 more sources
Gene cloning of a neutral ceramidase from the sphingolipid metabolic pathway based on transcriptome analysis of Amorphophallus muelleri. [PDF]
PLoS ONE, 2018 Amorphophallus is a perennial herbaceous plant species mainly distributed in the tropics or subtropics of Asia and Africa. It has been used as a traditional medicine for a long time and now is utilized for the pharmaceutical, chemical and agriculture ...
Lin Zhong +7 more
doaj +1 more source
Ceramidase activity in porcine epidermis [PDF]
FEBS Letters, 1990 This report presents the first demonstration of a ceramide‐hydrolyzing activity in mammalian epidermis. An assay using fractions derived from porcine epidermis and synthetic [3H]ceramide is described, and it is shown that under the conditions used, the K m for ceramide is 110 μM and hydrolysis is linear for up to 2 h.
Wertz, Philip W., Downing, Donald T.
openaire +2 more sources
Frontiers in Physiology, 2023 Ceramidases (CDases) are vital sphingolipid enzymes involved in organismal growth and development. They have been reported as key mediators of thermal stress response.
Min Chen +7 more
doaj +1 more source
Small Molecule Inhibitors of Ceramidases [PDF]
Cellular Physiology and Biochemistry, 2014 The equilibrium between the pro-apoptotic ceramide and pro-vital sphingosine-1-phosphate is considered to be decisive for cell death or survival. The different ceramidases thus play key roles in cell fate and might offer attractive targets for pharmacological intervention.
Essa M. Saied, Christoph Arenz
openaire +3 more sources
The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines
Frontiers in Endocrinology, 2020 Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and cardiovascular disease. Recently, one particular lipid class has been shown to influence the development and sustainment of these diseases: ceramides.
Bianca C. Field +3 more
doaj +1 more source
PLoS ONE, 2016 ObjectiveExcess dietary lipids result in the accumulation of lipid metabolites including ceramides that can attenuate insulin signaling. There is evidence that a botanical extract of Urtica dioica L.
Diana N Obanda +5 more
doaj +1 more source