Results 21 to 30 of about 9,480 (220)
Adiponectin serenades ceramidase to improve metabolism
Molecular Metabolism, 2017 Saskia Reibe-Pal, Mark A. Febbraio
doaj +3 more sources
PLoS ONE, 2016 ObjectiveExcess dietary lipids result in the accumulation of lipid metabolites including ceramides that can attenuate insulin signaling. There is evidence that a botanical extract of Urtica dioica L.
Diana N Obanda +5 more
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Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells [PDF]
, 2017 Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine. This reaction lowers intracellular ceramide levels and concomitantly generates sphingosine used for sphingosine-1-phosphate (
Ganesan, Anand +8 more
core +1 more source
Ceramidase activity in porcine epidermis [PDF]
FEBS Letters, 1990 This report presents the first demonstration of a ceramide‐hydrolyzing activity in mammalian epidermis. An assay using fractions derived from porcine epidermis and synthetic [3H]ceramide is described, and it is shown that under the conditions used, the K m for ceramide is 110 μM and hydrolysis is linear for up to 2 h.
Wertz, Philip W., Downing, Donald T.
openaire +2 more sources
New fluorogenic probes for neutral and alkaline ceramidases
Journal of Lipid Research, 2019 New fluorogenic ceramidase substrates derived from the N-acyl modification of our previously reported probes (RBM14) are reported. While none of the new probes were superior to the known RBM14C12 as acid ceramidase substrates, the corresponding nervonic ...
Mireia Casasampere +9 more
doaj +1 more source
Farber disease: clinical presentation, pathogenesis and a new approach to treatment [PDF]
, 2007 Background Farber Disease is an autosomal-recessively inherited, lysosomal storage disorder caused by acid ceramidase deficiency and associated with distinct clinical phenotypes.
Karoline Ehlert +5 more
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Small Molecule Inhibitors of Ceramidases [PDF]
Cellular Physiology and Biochemistry, 2014 The equilibrium between the pro-apoptotic ceramide and pro-vital sphingosine-1-phosphate is considered to be decisive for cell death or survival. The different ceramidases thus play key roles in cell fate and might offer attractive targets for pharmacological intervention.
Essa M. Saied, Christoph Arenz
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PLoS ONE, 2013 The tumor suppressor PTEN is now understood to regulate cellular processes at the cytoplasmic membrane, where it classically regulates PI3K signaling, as well as in the nucleus where multiple roles in controlling cell cycle and genome stability have been
Thomas H Beckham +5 more
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Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. [PDF]
PLoS ONE, 2017 Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer.
Aiping Bai +5 more
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Respiratory Research, 2023 Background Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and efficiency of acid ceramidase gene
Michael G. Katz +7 more
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