Results 41 to 50 of about 6,648 (196)

High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC inhibitors has attracted increasing ...
Mazen Aseeri, José Luis Abad, Antonio Delgado, Gemma Fabriàs, Gemma Triola, Josefina Casas   +5 more
doaj   +1 more source

Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets

Journal of Lipid Research, 2018
In patients with asthma or chronic obstructive pulmonary disease, rhinovirus (RV) infections can provoke acute worsening of disease, and limited treatment options exist.
An Nguyen, Anabel Guedán, Aurelie Mousnier, Dawid Swieboda, Qifeng Zhang, Dorottya Horkai, Nicolas Le Novere, Roberto Solari, Michael J.O. Wakelam   +8 more
doaj   +1 more source

Inhibition of ceramide accumulation in AdipoR1–/– mice increases photoreceptor survival and improves vision

JCI Insight, 2022
Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been associated with nonsyndromic and syndromic retinitis pigmentosa.
Dominik Lewandowski, Andrzej T. Foik, Roman Smidak, Elliot H. Choi, Jianye Zhang, Thanh Hoang, Aleksander Tworak, Susie Suh, Henri Leinonen, Zhiqian Dong, Antonio F.M. Pinto, Emily Tom, Jennings Luu, Joan Lee, Xiuli Ma, Erhard Bieberich, Seth Blackshaw, Alan Saghatelian, David C. Lyon, Dorota Skowronska-Krawczyk, Marcin Tabaka, Krzysztof Palczewski   +21 more
doaj   +1 more source

Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis. [PDF]

, 2020
Rationale: In cystic fibrosis the major cause of morbidity and mortality is lung disease characterized by inflammation and infection. The influence of sphingolipid metabolism is poorly understood with a lack of studies using human airway model systems ...
Ward, Christopher, Simpson, A. John, Gallagher, John, Verdon, Bernard, Mavin, Emily, Gulbins, Erich, Kramer, Elizabeth, Becker, Katrin, Schuchman, Edward, Fisher, Andrew, Koulman, Albert, Haq, Iram, Mcdonnell, Melissa, Gardner, Aaron, Trigg, Alexandra, Gray, Michael, Clancy, John, Saint-Criq, Vinciane, Brodlie, Malcolm   +18 more
core   +2 more sources

Absorption and lipoprotein transport of sphingomyelin

Journal of Lipid Research, 2006
Dietary sphingomyelin (SM) is hydrolyzed by intestinal alkaline sphingomyelinase and neutral ceramidase to sphingosine, which is absorbed and converted to palmitic acid and acylated into chylomicron triglycerides (TGs).
Åke Nilsson, Rui-Dong Duan
doaj   +1 more source

Adiponectin serenades ceramidase to improve metabolism

Molecular Metabolism, 2017
Saskia Reibe-Pal, Mark A. Febbraio
doaj   +3 more sources

ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS

, 2013
The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I
PIOMELLI DANIELE, REALINI NATALIA, MOR MARCO, PAGLIUCA CHIARA, PIZZIRANI DANIELA, SCARPELLI RITA, BANDIERA TIZIANO   +6 more
openaire   +6 more sources

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Regulation of neutral ceramidase in glomerular messangial cells [PDF]

, 2009
During the past several years, ceramide has emerged as an important second messenger triggering cell responses including proliferation, differentiation, growth arrest and apoptosis.
Franzen, Rochus
core  

Presence of Ceramidase Activity in Electronegative LDL

International Journal of Molecular Sciences, 2022
Electronegative low-density lipoprotein (LDL(−)) is a minor modified fraction of human plasma LDL with several atherogenic properties. Among them is increased bioactive lipid mediator content, such as lysophosphatidylcholine (LPC), non-esterified fatty acids (NEFA), ceramide (Cer), and sphingosine (Sph), which are related to the presence of some ...
Núria Puig, Jose Rives, Montserrat Estruch, Ana Aguilera-Simon, Noemi Rotllan, Mercedes Camacho, Núria Colomé, Francesc Canals, José Luis Sánchez-Quesada, Sonia Benitez   +9 more
openaire   +6 more sources