Results 41 to 50 of about 7,033 (216)
PLoS ONE, 2013 The tumor suppressor PTEN is now understood to regulate cellular processes at the cytoplasmic membrane, where it classically regulates PI3K signaling, as well as in the nucleus where multiple roles in controlling cell cycle and genome stability have been
Thomas H Beckham +5 more
doaj +1 more source
Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. [PDF]
PLoS ONE, 2017 Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer.
Aiping Bai +5 more
doaj +1 more source
Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury
Journal of Lipid Research, 2022 Cisplatin is a commonly used chemotherapeutic for the treatment of many solid organ cancers; however, its effectiveness is limited by the development of acute kidney injury (AKI) in 30% of patients. AKI is driven by proximal tubule cell death, leading to
Sophia M. Sears +12 more
semanticscholar +1 more source
A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy-Induced Cardiotoxicity. [PDF]
Adv Sci (Weinh)In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Yoo J +19 more
europepmc +2 more sources
Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis
Molecular Medicine, 2022 Acute pancreatitis is the sudden inflammation of the pancreas. Severe cases of acute pancreatitis are potentially fatal and have no specific treatment available. Premature trypsinogen activation could initiate acute pancreatitis.
Juan Xiao +4 more
semanticscholar +1 more source
Cells, 2020 Changes in sphingolipid metabolism have been suggested to contribute to the pathophysiology of major depression. In this study, we investigated the activity of acid and neutral sphingomyelinases (ASM, NSM) and ceramidases (AC, NC), respectively, in ...
Iulia Zoicas +5 more
doaj +1 more source
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Science Translational Medicine, 2020 Acid ceramidase inhibition promotes YAP/TAZ degradation to inactivate fibroblasts, decrease matrix stiffness, and reduce fibrosis in mice. Making a case for aCDase inhibition Activation of YAP/TAZ mechanosignaling promotes organ fibrosis.
Sarah Alsamman +32 more
semanticscholar +1 more source
Bioengineered, 2022 The involvement of certain circular RNAs (circRNAs) in the development of hepatocellular carcinoma (HCC) has been reported. Herein, this study aimed to investigate the function and mechanism of circ_0001955 in HCC tumorigenesis.
Kaizong Bai, Yubo Ma, Jian Li
semanticscholar +1 more source
Scientific Reports, 2021 Acid ceramidase (AC) is a lysosomal hydrolase encoded by the ASAH1 gene, which cleaves ceramides into sphingosine and fatty acid. AC is expressed at high levels in most human melanoma cell lines and may confer resistance against chemotherapeutic agents ...
Michele Lai +8 more
semanticscholar +1 more source
Frontiers in Plant Science, 2015 Ceramidases hydrolyze ceramide into sphingosine and fatty acids and, although ceramidases function as key regulators of sphingolipid homeostasis in mammals, their roles in plants remain largely unknown.
Jian eLi +7 more
doaj +1 more source