Results 41 to 50 of about 9,480 (220)
Journal of Lipid Research, 2018 In patients with asthma or chronic obstructive pulmonary disease, rhinovirus (RV) infections can provoke acute worsening of disease, and limited treatment options exist.
An Nguyen +8 more
doaj +1 more source
Long-term biopermanence of ceramides, cholesteryl esters, and ether-linked triglycerides with very-long-chain PUFA in the cadmium-damaged testis [PDF]
, 2014 Cadmium is known to harm rat testis by causing the dose-dependent apoptotic or necrotic death of seminiferous epithelium cells. Here we investigated how this affects the lipids with long-chain (C18-C22) and very-long-chain (C24-C32) polyunsaturated fatty
Aveldaño, Marta I. +1 more
core +2 more sources
Catalytic Mechanism of Eukaryotic Neutral Ceramidase [PDF]
Structure, 2015 Neutral ceramidases are key enzymes of sphingolipid metabolism that hydrolyze the fatty acyl/sphingosine amide linkage of ceramide at neutral pH. In this issue of Structure, Airola et al. (2015) present the first crystal structure of human nCDase and show how complexation with phosphate supports a new catalytic mechanism for Zn-dependent amidases while
Malinina, Lucy, Brown, Rhoderick E.
openaire +2 more sources
JCI Insight, 2022 Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been associated with nonsyndromic and syndromic retinitis pigmentosa.
Dominik Lewandowski +21 more
doaj +1 more source
Estrogen, angiogenesis, immunity and cell metabolism: Solving the puzzle [PDF]
, 2018 Estrogen plays an important role in the regulation of cardiovascular physiology and the immune system by inducing direct effects on multiple cell types including immune and vascular cells. Sex steroid hormones are implicated in cardiovascular protection,
Bolego, Chiara +5 more
core +2 more sources
Steroid profiling in male wobbler mouse, a model of Amyotrophic Lateral Sclerosis [PDF]
, 2016 The Wobbler mouse is an animal model for human motoneuron diseases, especially amyotrophic lateral sclerosis (ALS), used in the investigation of both pathology and therapeutic treatment.
Aprahamian, Fanny +9 more
core +1 more source
Absorption and lipoprotein transport of sphingomyelin
Journal of Lipid Research, 2006 Dietary sphingomyelin (SM) is hydrolyzed by intestinal alkaline sphingomyelinase and neutral ceramidase to sphingosine, which is absorbed and converted to palmitic acid and acylated into chylomicron triglycerides (TGs).
Åke Nilsson, Rui-Dong Duan
doaj +1 more source
Ceramidase Regulates Synaptic Vesicle Exocytosis and Trafficking [PDF]
The Journal of Neuroscience, 2004 A screen forDrosophilasynaptic dysfunction mutants identifiedslug-a-bed(slab). Theslabgene encodes ceramidase, a central enzyme in sphingolipid metabolism and regulation. Sphingolipids are major constituents of lipid rafts, membrane domains with roles in vesicle trafficking, and signaling pathways. Nullslabmutants arrest as fully developed embryos with
Jeffrey, Rohrbough +7 more
openaire +2 more sources
Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22 [PDF]
, 2012 A substantial proportion of familial colorectal cancer (CRC) is not a consequence of known susceptibility loci, such as mismatch repair (MMR) genes, supporting the existence of additional loci.
Allyson S Templeton +33 more
core +10 more sources
Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets [PDF]
, 2018 Gαi2, a heterotrimeric G-protein subunit, regulates various cell functions including ion channel activity, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz +12 more
core +1 more source