Results 51 to 60 of about 7,033 (216)

The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

bioRxiv, 2022
Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes.
Ann-Kathrin Günther, Matthias Hose, F. Schumacher, B. Kleuser, K. Matuschewski, K. Lang, E. Gulbins, J. Buer, A. Westendorf, W. Hansen   +9 more
semanticscholar   +1 more source

Measurement of neutral ceramidase activity in vitro and in vivo

Analytical Biochemistry, 2022
Neutral ceramidase and ceramide metabolism have been implicated in cancer development and inflammation. Ceramides and sphingolipids, in which belongs to a family of N-acyl linked lipids, have limited structural functions, but instead are biologically ...
Michael Simoes, A. Saleh, Y. Choi, M. Airola, J. Haley, N. Coant   +5 more
semanticscholar   +1 more source

Acid ceramidase and human disease

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Acid ceramidase (N-acylsphingosine deacylase, EC 3.5.1.23; AC) is the lipid hydrolase responsible for the degradation of ceramide into sphingosine and free fatty acids within lysosomes. The enzymatic activity was first identified over four decades ago, and is deficient in the inherited lipid storage disorder, Farber Lipogranulomatosis (Farber disease).
Park, Jae-Ho, Schuchman, Edward H.
openaire   +2 more sources

Host lipidome analysis during rhinovirus replication in HBECs identifies potential therapeutic targets

Journal of Lipid Research, 2018
In patients with asthma or chronic obstructive pulmonary disease, rhinovirus (RV) infections can provoke acute worsening of disease, and limited treatment options exist.
An Nguyen, Anabel Guedán, Aurelie Mousnier, Dawid Swieboda, Qifeng Zhang, Dorottya Horkai, Nicolas Le Novere, Roberto Solari, Michael J.O. Wakelam   +8 more
doaj   +1 more source

Adiponectin serenades ceramidase to improve metabolism

Molecular Metabolism, 2017
Saskia Reibe-Pal, Mark A. Febbraio
doaj   +3 more sources

COVID-19 and its clinical severity are associated with alterations of plasma sphingolipids and enzyme activities of sphingomyelinase and ceramidase

medRxiv, 2022
In the current pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19), a better understanding of the underlying mechanisms is essential to reduce morbidity and mortality and treat post-COVID-19 disease.
C. Mühle, A. Kremer, M. Vetter, Jonas A. Schmid, S. Achenbach, F. Schumacher, B. Lenz, C. Cougoule, N. Hoertel, A. Carpinteiro, E. Gulbins, B. Kleuser, J. Kornhuber   +12 more
semanticscholar   +1 more source

Inhibition of ceramide accumulation in AdipoR1–/– mice increases photoreceptor survival and improves vision

JCI Insight, 2022
Adiponectin receptor 1 (ADIPOR1) is a lipid and glucose metabolism regulator that possesses intrinsic ceramidase activity. Mutations of the ADIPOR1 gene have been associated with nonsyndromic and syndromic retinitis pigmentosa.
Dominik Lewandowski, Andrzej T. Foik, Roman Smidak, Elliot H. Choi, Jianye Zhang, Thanh Hoang, Aleksander Tworak, Susie Suh, Henri Leinonen, Zhiqian Dong, Antonio F.M. Pinto, Emily Tom, Jennings Luu, Joan Lee, Xiuli Ma, Erhard Bieberich, Seth Blackshaw, Alan Saghatelian, David C. Lyon, Dorota Skowronska-Krawczyk, Marcin Tabaka, Krzysztof Palczewski   +21 more
doaj   +1 more source

The manganese transporter SLC39A8 links alkaline ceramidase 1 to inflammatory bowel disease

Nature Communications
The metal ion transporter SLC39A8 is associated with physiological traits and diseases, including blood manganese (Mn) levels and inflammatory bowel diseases (IBD).
Eun-Kyung Choi, Thekkelnaycke M. Rajendiran, Tanu Soni, Jinho Park, Luisa Aring, C. Muraleedharan, V. Garcia-Hernandez, Nobuhiko Kamada, Linda C. Samuelson, Asma Nusrat, Shigeki Iwase, Y. Seo   +11 more
semanticscholar   +1 more source

Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis

bioRxiv, 2022
Nonalcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide, and is characterized by the accumulation of fat in the liver.
A. Yu, Carson Cable, Mahbubul Hoque Shihan, Sachin Sharma, Aras N. Mattis, Izolda Mileva, Y. Hannun, Caroline C. Duwaerts, Jennifer Y. Chen   +8 more
semanticscholar   +1 more source

Absorption and lipoprotein transport of sphingomyelin

Journal of Lipid Research, 2006
Dietary sphingomyelin (SM) is hydrolyzed by intestinal alkaline sphingomyelinase and neutral ceramidase to sphingosine, which is absorbed and converted to palmitic acid and acylated into chylomicron triglycerides (TGs).
Åke Nilsson, Rui-Dong Duan
doaj   +1 more source