Results 31 to 40 of about 6,648 (196)
New fluorogenic probes for neutral and alkaline ceramidases
Journal of Lipid Research, 2019 New fluorogenic ceramidase substrates derived from the N-acyl modification of our previously reported probes (RBM14) are reported. While none of the new probes were superior to the known RBM14C12 as acid ceramidase substrates, the corresponding nervonic ...
Mireia Casasampere +9 more
doaj +1 more source
Respiratory Research, 2023 Background Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and efficiency of acid ceramidase gene
Michael G. Katz +7 more
doaj +1 more source
Cells, 2020 Changes in sphingolipid metabolism have been suggested to contribute to the pathophysiology of major depression. In this study, we investigated the activity of acid and neutral sphingomyelinases (ASM, NSM) and ceramidases (AC, NC), respectively, in ...
Iulia Zoicas +5 more
doaj +1 more source
Cell Communication and Signaling, 2022 Acute myeloid leukemia (AML) is a type of leukemia with a poor prognosis and survival characterized by abnormal cell proliferation and differentiation.
Hamidreza Zalpoor +9 more
doaj +1 more source
Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues [PDF]
, 2011 The lipid-signalling molecule ceramide is known to induce apoptosis in a variety of cell types. Inhibition of the lysosomal acid ceramidase can increase cellular ceramide levels and thus induce apoptosis.
Jan Jasper Klein +2 more
core +1 more source
Targeting Acid Ceramidase to Attenuate Kidney Fibrosis [PDF]
, 2022 Chronic kidney disease (CKD) affects nearly 1 in 10 Canadians, a condition that in its end-stage has a worse prognosis than most cancers, and results in an annual healthcare cost of $40 billion.
Ki, Seung Hyun
core +1 more source
Cell-nonautonomous function of ceramidase in photoreceptor homeostasis
, 2011 Neutral ceramidase, a key enzyme of sphingolipid metabolism, hydrolyzes ceramide to sphingosine. These sphingolipids are critical structural components of cell membranes and act as second messengers in diverse signal transduction cascades.
Acharya, Jairaj K. +10 more
core +2 more sources
The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase. [PDF]
Acta Crystallogr D Struct BiolThis study reports the first crystal structure of human TANGO2, mutations of which are responsible for TANGO2 deficiency disorder. The crystallographic analysis demonstrates that interactions between heme and TANGO2 are nonspecific, helping to address ongoing questions about the role of TANGO2 as a heme‐trafficking protein.Recently, there has been ...
Zhou D, Chen L, Rose J, Wang BC.
europepmc +2 more sources
Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation. [PDF]
J ArrhythmDiabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Yoshimura K +9 more
europepmc +2 more sources
Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster +13 more
wiley +2 more sources