Results 31 to 40 of about 7,033 (216)
The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines
Frontiers in Endocrinology, 2020 Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and cardiovascular disease. Recently, one particular lipid class has been shown to influence the development and sustainment of these diseases: ceramides.
Bianca C. Field +3 more
doaj +1 more source
Frontiers in Physiology, 2023 Ceramidases (CDases) are vital sphingolipid enzymes involved in organismal growth and development. They have been reported as key mediators of thermal stress response.
Min Chen +7 more
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Neutral ceramidase-active site inhibitor chemotypes and binding modes
Bioorganic chemistry (Print), 2023 Ceramides impact a diverse array of biological functions and have been implicated in disease pathogenesis. The enzyme neutral ceramidase (nCDase) is a zinc-containing hydrolase and mediates the metabolism of ceramide to sphingosine (Sph), both in cells ...
N. Coant +18 more
semanticscholar +1 more source
Ceramidase activity in porcine epidermis [PDF]
FEBS Letters, 1990 This report presents the first demonstration of a ceramide‐hydrolyzing activity in mammalian epidermis. An assay using fractions derived from porcine epidermis and synthetic [3H]ceramide is described, and it is shown that under the conditions used, the K m for ceramide is 110 μM and hydrolysis is linear for up to 2 h.
Wertz, Philip W., Downing, Donald T.
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Cell Reports, 2022 SUMMARY It is not clear how the complex interactions between diet and intestinal immune cells protect the gut from infection. Neutral ceramidase (NcDase) plays a critical role in digesting dietary sphingolipids. We find that NcDase is an essential factor
Rui Sun +11 more
semanticscholar +1 more source
Gene cloning of a neutral ceramidase from the sphingolipid metabolic pathway based on transcriptome analysis of Amorphophallus muelleri. [PDF]
PLoS ONE, 2018 Amorphophallus is a perennial herbaceous plant species mainly distributed in the tropics or subtropics of Asia and Africa. It has been used as a traditional medicine for a long time and now is utilized for the pharmaceutical, chemical and agriculture ...
Lin Zhong +7 more
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Small Molecule Inhibitors of Ceramidases [PDF]
Cellular Physiology and Biochemistry, 2014 The equilibrium between the pro-apoptotic ceramide and pro-vital sphingosine-1-phosphate is considered to be decisive for cell death or survival. The different ceramidases thus play key roles in cell fate and might offer attractive targets for pharmacological intervention.
Essa M. Saied, Christoph Arenz
openaire +3 more sources
PLoS ONE, 2016 ObjectiveExcess dietary lipids result in the accumulation of lipid metabolites including ceramides that can attenuate insulin signaling. There is evidence that a botanical extract of Urtica dioica L.
Diana N Obanda +5 more
doaj +1 more source
New fluorogenic probes for neutral and alkaline ceramidases
Journal of Lipid Research, 2019 New fluorogenic ceramidase substrates derived from the N-acyl modification of our previously reported probes (RBM14) are reported. While none of the new probes were superior to the known RBM14C12 as acid ceramidase substrates, the corresponding nervonic ...
Mireia Casasampere +9 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Krabbe Disease (KD) is a lysosomal storage disorder characterized by the genetic deficiency of the lysosomal enzyme β-galactosyl-ceramidase (GALC).
R. Rebiai +14 more
semanticscholar +1 more source