Results 31 to 40 of about 9,480 (220)
Cell Communication and Signaling, 2022 Acute myeloid leukemia (AML) is a type of leukemia with a poor prognosis and survival characterized by abnormal cell proliferation and differentiation.
Hamidreza Zalpoor +9 more
doaj +1 more source
Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease [PDF]
, 2000 Farber's disease (FD) is a rare genetic disorder caused by ceramidase deficiency, which results in ceramide accumulation in lung, liver, colon, skeletal muscle, cartilage, and bone.
BUCCHIERI, Fabio +6 more
core +1 more source
Acid ceramidase promotes senescent cell survival
Aging, 2021 Cellular senescence is linked to chronic age-related diseases including atherosclerosis, diabetes, and neurodegeneration. Compared to proliferating cells, senescent cells express distinct subsets of proteins. In this study, we used cultured human diploid fibroblasts rendered senescent through replicative exhaustion or ionizing radiation to identify ...
Munk, Rachel +12 more
openaire +2 more sources
Presence of Ceramidase Activity in Electronegative LDL [PDF]
International Journal of Molecular Sciences, 2022 Electronegative low-density lipoprotein (LDL(−)) is a minor modified fraction of human plasma LDL with several atherogenic properties. Among them is increased bioactive lipid mediator content, such as lysophosphatidylcholine (LPC), non-esterified fatty acids (NEFA), ceramide (Cer), and sphingosine (Sph), which are related to the presence of some ...
Núria Puig +9 more
openaire +6 more sources
Cells, 2020 Changes in sphingolipid metabolism have been suggested to contribute to the pathophysiology of major depression. In this study, we investigated the activity of acid and neutral sphingomyelinases (ASM, NSM) and ceramidases (AC, NC), respectively, in ...
Iulia Zoicas +5 more
doaj +1 more source
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]
, 2017 The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio +16 more
core +3 more sources
Frontiers in Plant Science, 2015 Ceramidases hydrolyze ceramide into sphingosine and fatty acids and, although ceramidases function as key regulators of sphingolipid homeostasis in mammals, their roles in plants remain largely unknown.
Jian eLi +7 more
doaj +1 more source
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC inhibitors has attracted increasing ...
Mazen Aseeri +5 more
doaj +1 more source
Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation [PDF]
, 2006 Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts both as an extracellular ligand for endothelial differentiation gene receptor family and as an intracellular second messenger.
Brancaleone, V +9 more
core +1 more source
Role of ceramide in diabetes mellitus: evidence and mechanisms [PDF]
, 2013 Diabetes mellitus is a metabolic disease with multiple complications that causes serious diseases over the years. The condition leads to severe economic consequences and is reaching pandemic level globally.
Alaa Galadari +4 more
core +1 more source