Substrate specificity of rat brain ceramidase [PDF]
Journal of Lipid Research, 2002 In this study, the substrate specificity of a newly identified rat brain ceramidase (CDase) was investigated. To this end, the major functional groups and stereochemistry of ceramide (Cer) were evaluated for their influence on the hydrolysis of substrate
Samer El Bawab +5 more
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The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase. [PDF]
Acta Crystallogr D Struct BiolThis study reports the first crystal structure of human TANGO2, mutations of which are responsible for TANGO2 deficiency disorder. The crystallographic analysis demonstrates that interactions between heme and TANGO2 are nonspecific, helping to address ongoing questions about the role of TANGO2 as a heme‐trafficking protein.Recently, there has been ...
Zhou D, Chen L, Rose J, Wang BC.
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Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation. [PDF]
Adv Sci (Weinh)Deletion of ASAH2 in intestinal epithelial cells induces the accumulation of ganglioside GD3 via regulating ST8SIA1. GD3 is identified as the glycolipid ligand for the inhibitory receptor Siglec‐E on macrophages. GD3/Siglec‐E ligation polarizes macrophages and promotes the proliferation of colonic ST2+ T regulatory cells via the induction of IL‐33. The
Xu Z +11 more
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A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy-Induced Cardiotoxicity. [PDF]
Adv Sci (Weinh)In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Yoo J +19 more
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The Acid Ceramidase Is a SARS-CoV-2 Host Factor
Cells, 2022 SARS-CoV-2 variants such as the delta or omicron variants, with higher transmission rates, accelerated the global COVID-19 pandemic. Thus, novel therapeutic strategies need to be deployed.
Nina Geiger +14 more
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The Role of Ceramides in Diabetes and Cardiovascular Disease Regulation of Ceramides by Adipokines
Frontiers in Endocrinology, 2020 Metabolic dysfunction is intertwined with the pathophysiology of both diabetes and cardiovascular disease. Recently, one particular lipid class has been shown to influence the development and sustainment of these diseases: ceramides.
Bianca C. Field +3 more
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Frontiers in Physiology, 2023 Ceramidases (CDases) are vital sphingolipid enzymes involved in organismal growth and development. They have been reported as key mediators of thermal stress response.
Min Chen +7 more
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Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
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Gene cloning of a neutral ceramidase from the sphingolipid metabolic pathway based on transcriptome analysis of Amorphophallus muelleri. [PDF]
PLoS ONE, 2018 Amorphophallus is a perennial herbaceous plant species mainly distributed in the tropics or subtropics of Asia and Africa. It has been used as a traditional medicine for a long time and now is utilized for the pharmaceutical, chemical and agriculture ...
Lin Zhong +7 more
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Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation. [PDF]
, 2014 RATIONALE: Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered.
Booth, David +10 more
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