Results 11 to 20 of about 7,033 (216)
High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Ceramide has a key role in the regulation of cellular senescence and apoptosis. As Ceramide levels are lowered by the action of acid ceramidase (AC), abnormally expressed in various cancers, the identification of AC inhibitors has attracted increasing ...
Mazen Aseeri +5 more
doaj +2 more sources
Nature Communications, 2020 Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
Judith Lang +30 more
doaj +2 more sources
Pharmaceutics, 2018 Glioblastoma is the most common, malignant primary tumor of the central nervous system. The average prognosis for life expectancy after diagnosis, with the triad of surgery, chemotherapy, and radiation therapy, is less than 1.5 years.
Ha S. Nguyen +3 more
doaj +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance This study identifies the source of the toxic glycolipid, galactosylsphingosine (psychosine), which accumulates in the inherited demyelinating disorder, Krabbe disease.
Yedda Li +2 more
exaly +2 more sources
Presence of Ceramidase Activity in Electronegative LDL
International Journal of Molecular Sciences, 2022 Electronegative low-density lipoprotein (LDL(−)) is a minor modified fraction of human plasma LDL with several atherogenic properties. Among them is increased bioactive lipid mediator content, such as lysophosphatidylcholine (LPC), non-esterified fatty ...
N. Puig +9 more
semanticscholar +7 more sources
Substrate specificity of rat brain ceramidase [PDF]
Journal of Lipid Research, 2002 In this study, the substrate specificity of a newly identified rat brain ceramidase (CDase) was investigated. To this end, the major functional groups and stereochemistry of ceramide (Cer) were evaluated for their influence on the hydrolysis of substrate
Samer El Bawab +5 more
doaj +3 more sources
Structural basis for the activation of acid ceramidase [PDF]
Nature Communications, 2018 Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insight ...
Ahmad Gebai +4 more
doaj +3 more sources
Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization. [PDF]
J PatholAbstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Takada M +8 more
europepmc +2 more sources
The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase. [PDF]
Acta Crystallogr D Struct BiolThis study reports the first crystal structure of human TANGO2, mutations of which are responsible for TANGO2 deficiency disorder. The crystallographic analysis demonstrates that interactions between heme and TANGO2 are nonspecific, helping to address ongoing questions about the role of TANGO2 as a heme‐trafficking protein.Recently, there has been ...
Zhou D, Chen L, Rose J, Wang BC.
europepmc +2 more sources
Frontiers in Genetics, 2023 Background: The causal relationship between lipid-lowering drug (LLD) use and lung cancer risk is controversial, and the role of sphingolipid metabolism in this effect remains unclear.Methods: Genome-wide association study data on low-density lipoprotein
Honglin Li +7 more
doaj +1 more source