Results 11 to 20 of about 6,648 (196)
CDase is a pan-ceramidase inDrosophila [PDF]
Molecular Biology of the Cell, 2011 Ceramidases catalyze the conversion of ceramide to sphingosine. They are acylaminohydrolases that catalyze the deacylation of the amide-linked saturated fatty acid from ceramide to generate sphingosine. They also catalyze the reverse reaction of ceramide biosynthesis using sphingosine and fatty acid.
Yuan, Changqing +9 more
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Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. [PDF]
PLoS ONE, 2017 Acid ceramidase, which catalyzes ceramide hydrolysis to sphingosine and free fatty acid mainly in the lysosome, is being recognized as a potential therapeutic target for cancer.
Aiping Bai +5 more
doaj +2 more sources
An Arabidopsis neutral ceramidase mutant ncer1 accumulates hydroxyceramides and is sensitive to oxidative stress [PDF]
Frontiers in Plant Science, 2015 Ceramidases hydrolyze ceramide into sphingosine and fatty acids and, although ceramidases function as key regulators of sphingolipid homeostasis in mammals, their roles in plants remain largely unknown.
Jian eLi +7 more
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PLoS ONE, 2013 The tumor suppressor PTEN is now understood to regulate cellular processes at the cytoplasmic membrane, where it classically regulates PI3K signaling, as well as in the nucleus where multiple roles in controlling cell cycle and genome stability have been
Thomas H Beckham +5 more
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Improved synthesis of a fluorogenic ceramidase substrate [PDF]
Bioorganic & Medicinal Chemistry, 2010 Substantial interest has focused on the roles of sphingolipid metabolizing enzymes in a variety of hyperproliferative and inflammatory diseases. A key family of enzymes involved in these pathologies is the ceramidases. Ceramidases cleave the pro-apoptotic lipid ceramide into a long-chain fatty acid and sphingosine, which can then be further metabolized
Xia, Zuping +2 more
openaire +4 more sources
Molecular Genetics and Metabolism ReportsFarber Disease is a debilitating and lethal childhood disease of ceramide accumulation caused by acid ceramidase deficiency. The potent induction of a ligand-gated neutral ceramidase activity promoted by adiponectin may provide sufficient lowering of ...
Marie K. Norris +8 more
doaj +3 more sources
Substrate specificity of rat brain ceramidase [PDF]
Journal of Lipid Research, 2002 In this study, the substrate specificity of a newly identified rat brain ceramidase (CDase) was investigated. To this end, the major functional groups and stereochemistry of ceramide (Cer) were evaluated for their influence on the hydrolysis of substrate
Samer El Bawab +5 more
doaj +3 more sources
Nature CommunicationsThe tumor microenvironment is reprogrammed by cancer cells and participates in all stages of tumor progression. Neutral ceramidase is a key regulator of ceramide, the central intermediate in sphingolipid metabolism. The contribution of neutral ceramidase
Rui Sun +13 more
doaj +2 more sources
Structural basis for the activation of acid ceramidase [PDF]
Nature Communications, 2018 Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insight ...
Ahmad Gebai +4 more
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Acid ceramidase and sphingosine-1-phosphate lyase as biomarkers and therapeutic targets in cancer. (Ceramidasa ácida y esfingosina-1-fosfato liasa como biomarcadores y dianas terapéuticas en cáncer) [PDF]
, 2011 Cer and So are involved in regulation of apoptosis and cell cycle arrest while on the other hand S1P promotes cell growth and inhibits apoptosis. The antagonistic effects of these metabolites are regulated by enzymes that interconvert Cer, So, and S1P ...
Camacho Castillo, Luz del Carmen
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