Results 71 to 80 of about 9,480 (220)
F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway
Advanced Science, Volume 13, Issue 13, 3 March 2026.In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu +16 more
wiley +1 more source
Chronic glucocorticoid-rich milieu and liver dysfunction [PDF]
, 2016 We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats.
Castro, María Cecilia +7 more
core +6 more sources
Dysbiosis in the Pathogenesis of Atopic Dermatitis
The Journal of Dermatology, Volume 53, Issue 3, Page 388-398, March 2026.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal barrier dysfunction and immune dysregulation. Recent research highlights cutaneous dysbiosis as a critical factor in its pathogenesis. In this review, we summarize the interplay between the skin microbiota and host immunity, contrasting the homeostatic ...
Hiroki Okamoto, Yuumi Nakamura
wiley +1 more source
Journal of Lipid Research, 2015 Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids. Previously, we reported on the use of the RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity.
Mireia Casasampere +12 more
doaj +1 more source
On the role of bioactive sphingolipids and their metabolizing enzymes in cancer [PDF]
, 2017 Ceramide is a family of closely related molecules, which are presumed to be in the center of sphingolipid metabolism. Among sphingolipid metabolites, several ceramide subspecies and sphingosine induce apoptosis, cell cycle arrest and death, whereas ...
Ahmed, Dilruba
core +1 more source
The Reverse Activity of Human Acid Ceramidase [PDF]
Journal of Biological Chemistry, 2003 An overexpression system was recently developed to produce and purify recombinant, human acid ceramidase. In addition to ceramide hydrolysis, the purified enzyme was able to catalyze ceramide synthesis using [14C]lauric acid and sphingosine as substrates.
Nozomu, Okino +5 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 9, 13 February 2026.Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng +20 more
wiley +1 more source
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa
EMBO Molecular Medicine, 2014 Cystic fibrosis patients and patients with chronic obstructive pulmonary disease, trauma, burn wound, or patients requiring ventilation are susceptible to severe pulmonary infection by Pseudomonas aeruginosa.
Yael Pewzner‐Jung +14 more
doaj +1 more source
Data in Brief, 2018 Ceramide pathway is a key regulator in cell proliferation and apoptosis and oxidative stress up-regulate ceramides. Acid ceramidase (ACDase), neutral sphingomyelinase (NSMase) and glucosylceramide synthase (GCS) are critical enzymatic systems in ceramide
Mahdi Mashhadi Akbar Boojar +3 more
doaj +1 more source
Elevated plasma ceramide levels in post-menopausal women: a cross-sectional study. [PDF]
, 2019 Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease.
Armirotti, Andrea +9 more
core +1 more source