Results 71 to 80 of about 7,033 (216)

Adiponectin receptor agonist ameliorates cardiac lipotoxicity via enhancing ceramide metabolism in type 2 diabetic mice

Cell Death and Disease, 2022
Accumulation of lipids and their metabolites induces lipotoxicity in diabetic cardiomyopathy. Lowering ceramide concentration could reduce the impact of metabolic damage to target organs. Adiponectin improves lipotoxicity through its receptors (AdiopRs),
Yaeni Kim, Ji Hee Lim, Eun Nim Kim, Yu Ah Hong, Hun-Jun Park, Sungjin Chung, Bum Soon Choi, Yong-Soo Kim, Ji Yong Park, Hye Won Kim, Cheol Whee Park   +10 more
doaj   +1 more source

Cytotoxicity Profiling of Tenacibaculum Extracellular Products on Chinook Salmon (Oncorhynchus tshawytscha) Gill Cell Line, OTgill1PFR

Journal of Fish Diseases, EarlyView.
ABSTRACT Tenacibaculosis is an important disease of marine fishes caused by bacteria of the genus Tenacibaculum. Pathogenic Tenacibaculum species or serotypes, including Tenacibaculum maritimum, T. dicentrarchi, T. finnmarkense and T. soleae, have been isolated from farmed Chinook salmon (Oncorhynchus tshawytscha) during disease outbreaks in Aotearoa ...
Bjorn Böhmert, Michael Algie, Karthiga Kumanan, Kate S. Hutson, Georgina C. Dowd   +4 more
wiley   +1 more source

Functions of neutral ceramidase in the Golgi apparatus [PDF]

Journal of Lipid Research, 2018
Ceramidases hydrolyze ceramides into sphingosine and fatty acids, with sphingosine being further metabolized into sphingosine-1-phosphate (S1P); thus, ceramidases control the levels of these bioactive sphingolipids in cells and tissues. Neutral ceramidase (nCDase) is highly expressed in colorectal tissues, and a recent report showed that nCDase ...
Wataru Sakamoto, Nicolas Coant, Daniel Canals, Lina M. Obeid, Yusuf A. Hannun   +4 more
openaire   +3 more sources

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1

Stem Cells Translational Medicine, 2021
Gaucher disease (GD) is a lysosomal storage disorder caused by mutations in GBA1, the gene that encodes lysosomal β‐glucocerebrosidase (GCase). Mild mutations in GBA1 cause type 1 non‐neuronopathic GD, whereas severe mutations cause types 2 and 3 ...
Manasa P. Srikanth, Jace W. Jones, Maureen Kane, Ola Awad, Tea Soon Park, Elias T. Zambidis, Ricardo A. Feldman   +6 more
doaj   +1 more source

Ablation of Acid Ceramidase Impairs Autophagy and Mitochondria Activity in Melanoma Cells

International Journal of Molecular Sciences, 2021
Cutaneous melanoma is often resistant to therapy due to its high plasticity, as well as its ability to metabolise chemotherapeutic drugs. Sphingolipid signalling plays a pivotal role in its progression and metastasis.
Michele Lai, Veronica La Rocca, Rachel Amato, G. Freer, Mario Costa, P. G. Spezia, Paola Quaranta, G. Lombardo, D. Piomelli, M. Pistello   +9 more
semanticscholar   +1 more source

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

Improved synthesis of a fluorogenic ceramidase substrate [PDF]

Bioorganic & Medicinal Chemistry, 2010
Substantial interest has focused on the roles of sphingolipid metabolizing enzymes in a variety of hyperproliferative and inflammatory diseases. A key family of enzymes involved in these pathologies is the ceramidases. Ceramidases cleave the pro-apoptotic lipid ceramide into a long-chain fatty acid and sphingosine, which can then be further metabolized
Xia, Zuping, Draper, Jeremiah M, Smith, Charles D   +2 more
openaire   +3 more sources

ACER3-related leukoencephalopathy: expanding the clinical and imaging findings spectrum due to novel variants

Human Genomics, 2021
Background Leukodystrophies are the main subgroup of inherited CNS white matter disorders which cause significant mortality and morbidity in early years of life.
Ali Zare Dehnavi, Erfan Heidari, Maryam Rasulinezhad, Morteza Heidari, Mahmoud Reza Ashrafi, Mohammad Mahdi Hosseini, Fatemeh Sadeghzadeh, Mohammad-Sadegh Fallah, Noushin Rostampour, Amir Bahraini, Masoud Garshasbi, Ali Reza Tavasoli   +11 more
doaj   +1 more source

The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis

Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.
ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley   +1 more source

The Reverse Activity of Human Acid Ceramidase [PDF]

Journal of Biological Chemistry, 2003
An overexpression system was recently developed to produce and purify recombinant, human acid ceramidase. In addition to ceramide hydrolysis, the purified enzyme was able to catalyze ceramide synthesis using [14C]lauric acid and sphingosine as substrates.
Nozomu, Okino, Xingxuan, He, Shimon, Gatt, Konrad, Sandhoff, Makoto, Ito, Edward H, Schuchman   +5 more
openaire   +2 more sources