Results 81 to 90 of about 9,480 (220)

Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization [PDF]

, 2015
Background: Fertilization is a key physiological process for the preservation of the species. Consequently, different mechanisms affecting the sperm and the oocyte have been developed to ensure a successful fertilization. Thus, sperm acrosome reaction is
Avilés Sánchez, Manuel, Bernabeu, Rafael, García Hernández, Eva María, Gil-Izquierdo, Ángel, González-Brusi, Leopoldo, Guerrero, Jaime, Gómez-Torres, María José, Izquierdo-Rico, María José, Medina, Sonia, Orduna, Jesús, Savirón, María, Ten Morro, Jorge   +11 more
core   +2 more sources

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidative, inflammatory and metabolic function in recipient cells.
Sungji Cho, Hye Kyoung Sung, Khang Nguyen, Yubin Lei, Sivaporn Wannaiampikul, Brian Lee, Eddie Tam, Yihan Luo, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kacey J. Prentice, Scott A Summers, Dylan Burger, Gary Sweeney   +13 more
wiley   +1 more source

Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages

Nature Communications
The tumor microenvironment is reprogrammed by cancer cells and participates in all stages of tumor progression. Neutral ceramidase is a key regulator of ceramide, the central intermediate in sphingolipid metabolism. The contribution of neutral ceramidase
Rui Sun, Chao Lei, Zhishan Xu, Xuemei Gu, Liu Huang, Liang Chen, Yi Tan, Min Peng, Kavitha Yaddanapudi, Leah Siskind, Maiying Kong, Robert Mitchell, Jun Yan, Zhongbin Deng   +13 more
doaj   +1 more source

CLUSTERING OF SPECIFIC MOLECULES IN SHED VESICLES. [PDF]

, 2005
In several tumor cell lines serum addition causes release of vesicles that bud from the cell surface and can be purified from cell conditionated media. These vesicles are known to be involved in cell migration and tumor progression.
RIGOGLIUSO, Salvatrice, VITTORELLI, Maria Letizia   +1 more
core  

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation [PDF]

, 2017
Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the
A Deshmukh, Albert Hofman, Albert Sun, Albert V Smith, Alex P Reiner, Alexander Teumer, Alexandre Pereira, Alfredo J Mansur, Alvaro Alonso, Anders Hamsten, Andre G Uitterlinden, Andrea R V R Horimoto, Andrew P Morris, Annette Peters, AP Boyle, Archie Campbell, Bastiaan Geelhoed, Blair H Smith, Bradford B Worrall, Bruce M Psaty, Bruno H Stricker, Carolina Roselli, Caroline Hayward, Cecilia M Lindgren, Charles Kooperberg, Christian Shaffer, Christine M Albert, Christopher D Anderson, Christopher Newton-Cheh, CJ Hoggart, CJ Willer, Claudia Schurmann, CT January, D Welter, Dan E Arking, Dan M Roden, Daniel I Chasman, Daniel J Rader, David Conen, David Porteous, David R Van Wagoner, Dawood Darbar, Derek Klarin, DF Gudbjartsson, DF Gudbjartsson, DF Seals, DM Lloyd-Jones, E Eden, Efthymia Vlachopoulou, EJ Benjamin, Elsayed Z Soliman, Emelia J Benjamin, Eric Boerwinkle, Erik Ingelsson, Erwin B Bottinger, F Dudbridge, Farid Radmanesh, G Laumet, Ganesh Chauhan, Graciela Delgado, Guillaume Paré, H Holm, Henry J Lin, Honghuang Lin, I Pe'er, Ian Ford, Ilkka Seppälä, Ingrid E Christophersen, J Gustav Smith, J Wouter Jukema, J Yang, Jan Heeringa, Jared W Magnani, Jari Laurikka, Jeffrey Haessler, Jemma C Hopewell, Jennifer A Brody, Jennifer Huffman, Jennifer Kriebel, Jerome I Rotter, Jie Huang, Jie Yao, John Barnard, Jonathan D Smith, Jonathan Rosand, Jorge A Wong, Jose E Krieger, Joshua C Bis, Joshua C Denny, Joylene E Siland, Juha Sinisalo, Jussi Hernesniemi, Karl-Heinz Jöckel, Kathryn L Lunetta, Kent D Taylor, Kjell Nikus, Lars Lannfelt, Lars Lind, LD Ward, Lenore J Launer, Leo-Pekka Lyytikäinen, Lewin Eisele, Lin Y Chen, Lorenz Risch, Lu-Chen Weng, Lynne J Hocking, M Arnold, M Benjamin Shoemaker, Maartje N Niemeijer, Man Li, Marco Perez, Marcus Dörr, Marcus E Kleber, Marina Arendt, Marja-Liisa Lokki, Marju Orho-Melander, Mark Chaffin, Markku Eskola, Martin Dichgans, Martina Müller-Nurasyid, Melanie Waldenberger, MF Sinner, Michiaki Kubo, Michiel Rienstra, Mika Kähönen, Mina K Chung, Molong Li, Moritz F Sinner, MR Nelson, Nancy L Pedersen, Natalia Rost, Nathan A Bihlmeyer, Nathan R Tucker, Niek Verweij, Nona Sotoodehnia, Olle Melander, Oscar H Franco, P Cejudo-Martin, P Weeke, Patrick T Ellinor, Patrik K Magnusson, Paul L Huang, Paul M Ridker, PC Sham, Peter Almgren, Peter E Weeke, Peter Lichtner, Peter W Macfarlane, Pim van der Harst, PT Ellinor, PT Ellinor, Qiong Yang, R Malik, Rainer Malik, Rajat Deo, RJ Pruim, Roopinder K Sandhu, Ruth J F Loos, S Kuriyama, S Lee, S Purcell, Sandosh Padmanabhan, Sebastian Clauss, Sekar Kathiresan, Seung Hoan Choi, Siegfried Perz, Siew-Kee Low, SS Chugh, ST Sherry, Stefan Gustafsson, Stefan Kääb, Stefan Weiss, Stefanie Aeschbacher, Stefanie Heilmann-Heimbach, Stella Trompet, Stephan B Felix, Stephanie Debette, Steven A Lubitz, Stuart A Scott, Susan R Heckbert, Svati H Shah, Sébastien Thériault, Tamara B Harris, Terho Lehtimäki, TH Pers, TH Pers, Toshihiro Tanaka, Traci M Bartz, Uwe Völker, Vilmundur Gudnason, Winfried März, Xiaoyan Yin, Xiuqing Guo, Y Benjamini, Yanick P Hagemeijer, Yii-Der Ida Chen, Yingchang Lu, Yoichiro Kamatani   +197 more
core   +9 more sources

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, Volume 7, Issue 2, February 2026.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

Saccharomyces cerevisiae depend on vesicular traffic between Golgi and vacuole when Inositolphosphorylceramide synthase Aur1 is inactivated [PDF]

, 2015
Inositolphosphorylceramide (IPC) and its mannosylated derivatives are the only complex sphingolipids of yeast. Their synthesis can be reduced by aureobasidin A (AbA), which specifically inhibits the IPC synthase Aur1.
Conzelmann, Andreas, Ejsing, Christer S, Mallela, Shamroop K, Roubaty, Carole, Vazquez, Hector M, Voynova, Natalia S   +5 more
core   +2 more sources

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 515-528, February 2026.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper, Alyssa Powers, Kevin P. Battaile, Al‐Walid Mohsen, David K. Johnson, Scott Lovell, Lina Ghaloul‐Gonzalez   +6 more
wiley   +1 more source

Sphingolipids in Emotional Well‐Being

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Sphingolipids are essential constituents of neuronal membranes and are increasingly recognized as contributors to the key behavioral manifestations associated with emotional well‐being. ABSTRACT Emotional well‐being is a multifactorial concept, which comprises not only life quality of human individuals, but also their mental and physical health.
L. S. Kalinichenko, I. Zoicas, C. Mühle, J. Kornhuber, C. P. Müller   +4 more
wiley   +1 more source

Ceramides and mitochondrial fatty acid oxidation in obesity [PDF]

, 2017
: Obesity is an epidemic, complex disease that is characterized by increased glucose, lipids, and low-grade inflammation in the circulation, among other factors.
Casals i Farré, Núria, Fucho Salvador, Raquel, Herrero Rodríguez, Laura, Serra i Cucurull, Dolors   +3 more
core   +1 more source