Results 81 to 90 of about 6,648 (196)
Infection and Drug Resistance, 2023 Qian Qi,1,2,* Jiawei Xu,1,2,* Yujiao Wang,3,* Jian Zhang,1 Mingxia Gao,1 Yu Li,4 Liang Dong1,2 1Department of Respiratory, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong ...
Qi Q +6 more
doaj
Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway
Journal of Pharmacological Sciences, 2010 .: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromatography using
Eiko Tada +7 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 4, April 2026.This phase II trial investigated the safety and efficacy of opaganib in combination with abiraterone or enzalutamide in patients with castration‐resistant prostate cancer (CRPC). While the study did not meet its disease control efficacy endpoint, there was evidence of clinical activity in a subset of patients.
Jacqueline T. Brown +12 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Elevated levels of ceramide, a sphingolipid known to cause a transition from nitric oxide (NO)– to hydrogen peroxide–dependent flow‐induced dilation (FID) in human arterioles, correlate with adverse cardiac events.
Mary E. Schulz +4 more
doaj +1 more source
Characterization of ceramidase inhibitors in the human keratinocyte cell line HaCaT
, 2002 0. Titelblatt und Inhaltsverzeichnis Abkürzungen 1 1. Einleitung 1 1.1 Struktur und Biosynthese von Ceramid 1 1.2 Der Sphingomyelinzyklus 2 1.3 Biologische Rolle von Ceramid 4 1.3.1 Ceramid und Apoptose 4 1.3.2 Haut und Apoptose 9 1.3.3 ...
Goltz, Gerit
core +1 more source
Inhibiting Acid Ceramidase with Phenolphthalein Compounds as a Potential Cancer Treatment
, 2022 Cancer is a prevalent issue. The most common current treatments for cancer include radiation therapy and chemotherapy. However, recent developments in cancer treatment have included targeted therapy.
Smith, Sybil
core
Characterization of genes involved in ceramide metabolism in the Pacific oyster (
BMC Research Notes, 2012 Background The lipid signaling molecule, ceramide, is a key component of the vertebrate stress response, however, there is limited information concerning its role in invertebrate species.
Timmins-Schiffman Emma, Roberts Steven
doaj +1 more source
Acid Ceramidase Promotes Akt Activation and Nuclear Export of PTEN through S1P Signaling [PDF]
, 2013 Prostate cancer is a leading cause of cancer and cancer-related mortality in males in the United States. Acid ceramidase is frequently overexpressed in prostate cancer and catalyzes the deacylation of proapoptotic ceramide into sphingosine.
Beckham, Thomas Hendrix
core
, 2016 Fully differentiated 3T3-L1 adipocytes were incubated with indicated doses of palmitate for 72 hours and (A) cell extracts were examined for acid ceramidase and neutral ceramidase expression.
Peng Zhao (128233) +5 more
core +1 more source
Role of neutral ceramidase in colon cancer
The FASEB Journal, 2016 ABSTRACT Alterations in sphingolipid metabolism, especially ceramide and sphingosine 1‐phosphate, have been linked to colon cancer, suggesting that enzymes of sphingolipid metabolism may emerge as novel regulators and targets in colon cancer.
Mónica, García-Barros +13 more
openaire +3 more sources