Results 91 to 100 of about 9,480 (220)

Decreased Sphingosine Due to Down-Regulation of Acid Ceramidase Expression in Airway of Bronchiectasis Patients: A Potential Contributor to Pseudomonas aeruginosa Infection

Infection and Drug Resistance, 2023
Qian Qi,1,2,* Jiawei Xu,1,2,* Yujiao Wang,3,* Jian Zhang,1 Mingxia Gao,1 Yu Li,4 Liang Dong1,2 1Department of Respiratory, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong ...
Qi Q, Xu J, Wang Y, Zhang J, Gao M, Li Y, Dong L   +6 more
doaj  

A Somatic Mutation in HIF‐2α Affects Glucose and Lipid Metabolism via CD36 and Ceramide

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
A mutation within the C‐terminal transactivation domain of HIF‐2α enhances Cd36 expression by increased transactivation activity, leading to ceramide accumulation and disruption of glucose and lipid metabolism. Inhibition of ceramide synthesis by myriocin reduces ceramide levels and ameliorates these metabolic disturbances.
Feiqiong Gao, Xudong Feng, Qigu Yao, Weiqin Ji, Xinying Zhang, Qiaoling Pan, Bin Zhu, Jiong Yu, Hongcui Cao, Xianfeng Zhang   +9 more
wiley   +1 more source

Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase–Mediated Pathway

Journal of Pharmacological Sciences, 2010
.: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromatography using
Eiko Tada, Kaori Toyomura, Hiroyuki Nakamura, Hirotsune Sasaki, Takeshi Saito, Masayuki Kaneko, Yasunobu Okuma, Toshihiko Murayama   +7 more
doaj   +1 more source

Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders [PDF]

, 2017
Intracellular accumulation of lipids and swollen dysfunctional lysosomes are linked to several neurodegenerative diseases, including lysosomal storage disorders (LSD).
Acharya JK, Acharya U, Avinash Khandelwal, Bilen J, Billeter JC, Brankatschk M, Carvalho M, Carvalho M, Cheng H, Cutler RG, Dasgupta U, Dermaut B, Dominik Schwudke, Ejsing CS, Fergestad T, Georgakopoulou EA, Ghosh A, Gray DA, Guan XL, Gutierrez E, Han X, Hebbar S, Hebbar S, Herzog R, Hickey AJ, Hindle S, Hindle SJ, Hoglinger D, Ito M, Jang S, Joanne Y. Yew, Julie Brill, Kawahara A, Kumarasamy SK, Lim A, Liu L, Lloyd-Evans E, Matyash V, Mi H, Milton VJ, Nakano Y, Osborne N, Palm W, Panchal M, Pantoja M, R. Jayashree, Rohrbough J, Rong Y, Samantha J. Hindle, Sampaio JL, Sarita Hebbar, Sasamura T, Schneider CA, Schwudke D, Sean T. Sweeney, Seppo A, Shevchenko A, Shevchenko A, Starostina E, Stern CA, Sweeney ST, te Vruchte D, Thomas PD, Venkatachalam K, Xu Y, Yew JY, Yin Ning Chiang, Zigdon H   +67 more
core   +1 more source

Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow‐Induced Dilation in the Human Microvasculature

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Elevated levels of ceramide, a sphingolipid known to cause a transition from nitric oxide (NO)– to hydrogen peroxide–dependent flow‐induced dilation (FID) in human arterioles, correlate with adverse cardiac events.
Mary E. Schulz, Boran Katunaric, Joseph C. Hockenberry, David D. Gutterman, Julie K. Freed   +4 more
doaj   +1 more source

Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans [PDF]

, 2003
Sphingolipids are ubiquitous membrane constituents whose metabolites function as signaling molecules in eukaryotic cells. Sphingosine 1-phosphate, a key sphingolipid second messenger, regulates proliferation, motility, invasiveness, and programmed cell ...
Fyrst, Henrik, Heinecke, Karie, Mendel, Jane, Saba, Julie D.   +3 more
core   +1 more source

The Gut Microbiota–Insulin Resistance Axis: Mechanisms, Clinical Implications, and Therapeutic Potential

FASEB BioAdvances, Volume 8, Issue 1, January 2026.
Dysbiosis‐induced alterations in microbial metabolite production promote intestinal barrier disruption and systemic inflammation, driving insulin resistance and metabolic dysfunction. Microbiota‐targeting therapies represent promising approaches to restore host metabolic health.
Mohamad Al Qassab, Nadim Chaarani, Amira Hamou, Rasha Harb, Ahmad Jradi, Mira Zeineddine, Hilda E. Ghadieh, Ziad Abi Khattar, Sami Azar, Amjad Kanaan, Frederic Harb   +10 more
wiley   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Brush border digestion : development of a physiologically relevant in vitro model : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Physiology at Massey University, Manawatū, New Zealand [PDF]

, 2018
Chapter Two has, in part, been published in the Springer publication, Reviews of Physiology, Biochemistry and Pharmacology, but the Author retains the right to publish the material in any collection consisting of the Author's own works: Hooton, D ...
Hooton, Diane Frances
core  

11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle [PDF]

, 2009
OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown.
A. Yu, Abdallah, Aguirre, Araki, C. Lenaghan, D. Laber, D. M. Smith, Danielsson, Djurhuus, Draznin, Fraser, G. Convey, G. G. Lavery, Geraghty, Giorgino, Giorgino, Giorgino, Hanada, I. J. Bujalska, J. K. Sethi, J. W. Tomlinson, Jang, K. Hegyi, Kido, Kim, L. L. Gathercole, Larsson, Liu, M. Sherlock, M  ssig, P. M. Stewart, R. Mayers, S. A. Morgan, Saad, van Staa, Watson, Whorwood, Zhang   +37 more
core   +3 more sources