Results 91 to 100 of about 6,648 (196)

Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells

Lipids in Health and Disease, 2008
Background The ceramide generation is an early event in the apoptotic response to numerous stimuli including the oxidative stress and ceramide analogs mimic the stress effect and induce apoptosis.
Shakhova Elena G, Babenko Nataliya A
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Acid ceramidase inhibition: a novel target for cancer therapy

, 2008
During the last decade, sphingolipid deregulation, namely the balance between the pro-apoptotic molecule ceramide and the anti-apoptotic sphingolipid sphingosine-1- phosphate, has emerged as an important factor in cancer pathology and resistance to ...
Liu, X, Szulc, Z, Tavassoli, Mahvash, Szulc, Zdzislaw, Mahdy, Ayman E M, Zeidan, Y H, Holman, David H, Mahdy, A E M, Holman, D H, Rubinchik, Semyon, Liu, Xiang, Dong, J Y, Guo, G W, Tavassoli, M, El-Zawahry, A M, Rubinchik, S, Elojeimy, Saeed, Turner, Lorianne S, Bielawska, Alicja, Hannun, Y A, Turner, L S, Elojeimy, S, Dong, Jian-Yun, Bielawski, J, Hannun, Yusuf A, Norris, J S, El-Zawahry, Ahmed M, Guo, Gui-wen, Zeidan, Youssef H, Bielawski, Jacek, Keane, Thomas E, Norris, James S, Bielawska, A, Keane, T E   +33 more
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Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet β-cells

, 2009
Ceramidase hydrolyzes ceramide and produces sphingosine as a substrate of sphingosine kinase (SPHK), which transforms sphingosine to sphingosine-1-phosphate. It has been reported that cytokines elicit SPHK activation in rat β-cells.
Liu, Chao, Liao, Duan-fang, Jin, Junfei, Shan, Xiaohong, Lu, Yibing, Xu, Jiarong, Zhu, Qun, Miao, Heng, You, Na   +8 more
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C26-Ceramide as highly sensitive biomarker for the diagnosis of Farber Disease

Scientific Reports, 2017
Farber disease (FD) is a rare autosomal recessive disease caused by mutations in the acid ceramidase gene (ASAH1). Low ceramidase activity results in the accumulation of fatty substances, mainly ceramides.
Claudia Cozma, Marius-Ionuț Iurașcu, Sabrina Eichler, Marina Hovakimyan, Oliver Brandau, Susanne Zielke, Tobias Böttcher, Anne-Katrin Giese, Jan Lukas, Arndt Rolfs   +9 more
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The effects of rosmarinic acid and carnosic acid on cell viability and ceramide metabolism in the HEP-G2 cells

یافته‌های نوین در علوم زیستی, 2016
Carnosic acid and Rosmarinic acid are family of polyphenols that are found in Rosmary plant. They have property biological behaviors such as anti-cancer, anti-viral and anti-oxidants.
Narges Najjarpour, Masoud Mashadi Akbar Boujar   +1 more
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쥐 Acid ceramidase homologue 유전자에 대한 연구

, 2001
학위논문(석사) - 한국과학기술원 : 생물과학과, 2001.2, [ viii, 72 p. ]Ceramidase is an enzyme that is responsible for ceramide hydrolysis to sphingosine and fatty acid. Different forms of ceramidase activity have been identified, including an acid, alkaline and neutral ...
Kim, Ho-Min, 김호민
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Human Acid Ceramidase [PDF]

Journal of Biological Chemistry, 2001
Klaus Ferlinz, Guido Kopal, Katussevani Bernardo, Thomas Linke, Julia Bär, Bernadette Breiden, Ulrich Neumann, Florian Lang, Edward H. Schuchman, Konrad Sandhoff   +9 more
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Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity

Communications Biology
Two mammalian homologs of systemic RNA interference defective protein 1 (SID-1) (SIDT1/2) are suggested to function as double-stranded RNA (dsRNA) transporters for extracellular dsRNA uptake or for release of incorporated dsRNA from lysosome to cytoplasm.
Yoshinori Hirano, Umeharu Ohto, Ikuyo Ichi, Ryota Sato, Kensuke Miyake, Toshiyuki Shimizu   +5 more
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Acid Ceramidase [PDF]

, 2020
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Overexpression of human acid ceramidase precursor and variants of the catalytic center in Sf9 cells : Analysis of ceramidase maturation, autocatalytic processing and interaction with Sap-D [PDF]

, 2009
Ceramides are important building blocks of eukaryotic membranes and primarily serve as membrane anchors of GSLs and sphingomyelins. The lysosomal degradation of ceramide is catalyzed by acid ceramidase and requires the interaction with Sap-D in vivo ...
Chien, Chih-Te
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