Results 111 to 120 of about 9,480 (220)

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets

Journal of Lipid Research, 2005
The bioactive molecule sphingosine 1-phosphate (S1P) is abundantly stored in platelets and can be released extracellularly. However, although they have high sphingosine (Sph) kinase activity, platelets lack the de novo sphingolipid biosynthesis necessary
Motohiro Tani, Takamitsu Sano, Makoto Ito, Yasuyuki Igarashi   +3 more
doaj   +1 more source

The effects of rosmarinic acid and carnosic acid on cell viability and ceramide metabolism in the HEP-G2 cells

یافته‌های نوین در علوم زیستی, 2016
Carnosic acid and Rosmarinic acid are family of polyphenols that are found in Rosmary plant. They have property biological behaviors such as anti-cancer, anti-viral and anti-oxidants.
Narges Najjarpour, Masoud Mashadi Akbar Boujar   +1 more
doaj  

C26-Ceramide as highly sensitive biomarker for the diagnosis of Farber Disease

Scientific Reports, 2017
Farber disease (FD) is a rare autosomal recessive disease caused by mutations in the acid ceramidase gene (ASAH1). Low ceramidase activity results in the accumulation of fatty substances, mainly ceramides.
Claudia Cozma, Marius-Ionuț Iurașcu, Sabrina Eichler, Marina Hovakimyan, Oliver Brandau, Susanne Zielke, Tobias Böttcher, Anne-Katrin Giese, Jan Lukas, Arndt Rolfs   +9 more
doaj   +1 more source

Human Acid Ceramidase [PDF]

Journal of Biological Chemistry, 2001
Klaus Ferlinz, Guido Kopal, Katussevani Bernardo, Thomas Linke, Julia Bär, Bernadette Breiden, Ulrich Neumann, Florian Lang, Edward H. Schuchman, Konrad Sandhoff   +9 more
openaire   +1 more source

Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice

Acta Dermato-Venereologica, 2019
Sphingosine-1-phosphate (S1P) is a signalling sphingolipid metabolite that regulates important cell processes, including cell proliferation and apoptosis.
Sun-Hye Shin, Kyung-Ah Cho, Soojung Hahn, Younghay Lee, Yu-He Kim, So-Youn Woo, Kyung-Ha Ryu, Woo-Jae Park, Joo-Won Park   +8 more
doaj   +1 more source

An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. [PDF]

, 2019
Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the glucocorticoid receptor in hepatocytes and adipocytes, is required for ...
Cheang, Rachel T, Chen, Tzu-Chieh, Fitch, Mark D, Gray, Nora E, Hellerstein, Marc K, Kanamaluru, Deepthi, Lee, Justin Y, Lee, Rebecca A, Tan, Jenna H, Tsai, Sam L, Wang, Jen-Chywan, Yiv, Nicholas   +11 more
core  

Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling [PDF]

, 2014
Adiponectin is an adipocyte-secreted adipokine with pleiotropic actions. Clinical evidence has shown that serum adiponectin levels are increased and that adiponectin can protect pancreatic beta cells against apoptosis, which suggests that adiponectin may
Cheng, X, Da, Y, Huang, B, Li, M, Peng, M, Wang, D, Xu, A, Xue, Z, Yao, Z, Zhang, N, Zhang, R   +10 more
core   +1 more source

Secretoma do fungo biocontrolador Metarhizium anisopliae relacionado à infecção do carrapato bovino Rhipicephalus microplus [PDF]

, 2016
O controle biológico é considerado uma alternativa natural e ecológica para o controle de pragas, evitando os problemas causados pela utilização de agentes químicos.
Scherer, Karine
core  

Acid Ceramidase in Melanoma [PDF]

Journal of Biological Chemistry, 2016
Natalia Realini, Francesca Palese, Daniela Pizzirani, Silvia Pontis, Abdul Basit, Anders Bach, Anand Ganesan, Daniele Piomelli   +7 more
openaire   +1 more source

Farber disease: Understanding a fatal childhood disorder and dissecting ceramide biology [PDF]

, 2013
Farber S, Mark S. Sands
core   +2 more sources