Results 101 to 110 of about 7,033 (216)

Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow‐Induced Dilation in the Human Microvasculature

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Elevated levels of ceramide, a sphingolipid known to cause a transition from nitric oxide (NO)– to hydrogen peroxide–dependent flow‐induced dilation (FID) in human arterioles, correlate with adverse cardiac events.
Mary E. Schulz, Boran Katunaric, Joseph C. Hockenberry, David D. Gutterman, Julie K. Freed   +4 more
doaj   +1 more source

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidative, inflammatory and metabolic function in recipient cells.
Sungji Cho, Hye Kyoung Sung, Khang Nguyen, Yubin Lei, Sivaporn Wannaiampikul, Brian Lee, Eddie Tam, Yihan Luo, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kacey J. Prentice, Scott A Summers, Dylan Burger, Gary Sweeney   +13 more
wiley   +1 more source

Role of neutral ceramidase in colon cancer

The FASEB Journal, 2016
ABSTRACT Alterations in sphingolipid metabolism, especially ceramide and sphingosine 1‐phosphate, have been linked to colon cancer, suggesting that enzymes of sphingolipid metabolism may emerge as novel regulators and targets in colon cancer.
Mónica, García-Barros, Nicolas, Coant, Toshihiko, Kawamori, Masayuki, Wada, Ashley J, Snider, Jean-Philip, Truman, Bill X, Wu, Hideki, Furuya, Christopher J, Clarke, Agnieszka B, Bialkowska, Amr, Ghaleb, Vincent W, Yang, Lina M, Obeid, Yusuf A, Hannun   +13 more
openaire   +3 more sources

Intestinal neutral ceramidase exacerbates MASH pathogenesis

eGastroenterology
Background Metabolic dysfunction-associated steatotic liver disease and its more severe manifestation, metabolic dysfunction-associated steatohepatitis (MASH), are intimately linked to genetic factors, gut microbiota and barrier alteration.
Chao Lei, Ting Wang, Liang Chen, Xiang Zhang, Jing Feng, Zhongbin Deng, Craig J McClain, Xiaotong Song, Amanguli Tuohongerbieke, Regina Gasparetto, Yi Tan   +10 more
doaj   +1 more source

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, Volume 7, Issue 2, February 2026.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

Characterization of genes involved in ceramide metabolism in the Pacific oyster (Crassostrea gigas)

BMC Research Notes, 2012
Background The lipid signaling molecule, ceramide, is a key component of the vertebrate stress response, however, there is limited information concerning its role in invertebrate species.
Timmins-Schiffman Emma, Roberts Steven
doaj   +1 more source

Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells

Lipids in Health and Disease, 2008
Background The ceramide generation is an early event in the apoptotic response to numerous stimuli including the oxidative stress and ceramide analogs mimic the stress effect and induce apoptosis.
Shakhova Elena G, Babenko Nataliya A
doaj   +1 more source

Acid ceramidase deficiency: Farber disease and SMA-PME

Orphanet Journal of Rare Diseases, 2018
Acid ceramidase (ACDase) deficiency is a spectrum of disorders that includes a rare lysosomal storage disorder called Farber disease (FD) and a rare epileptic disorder called spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME).
Fabian P. S. Yu, S. Amintas, T. Levade, J. Medin   +3 more
semanticscholar   +1 more source

C26-Ceramide as highly sensitive biomarker for the diagnosis of Farber Disease

Scientific Reports, 2017
Farber disease (FD) is a rare autosomal recessive disease caused by mutations in the acid ceramidase gene (ASAH1). Low ceramidase activity results in the accumulation of fatty substances, mainly ceramides.
Claudia Cozma, Marius-Ionuț Iurașcu, Sabrina Eichler, Marina Hovakimyan, Oliver Brandau, Susanne Zielke, Tobias Böttcher, Anne-Katrin Giese, Jan Lukas, Arndt Rolfs   +9 more
doaj   +1 more source

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets

Journal of Lipid Research, 2005
The bioactive molecule sphingosine 1-phosphate (S1P) is abundantly stored in platelets and can be released extracellularly. However, although they have high sphingosine (Sph) kinase activity, platelets lack the de novo sphingolipid biosynthesis necessary
Motohiro Tani, Takamitsu Sano, Makoto Ito, Yasuyuki Igarashi   +3 more
doaj   +1 more source