Results 101 to 110 of about 9,480 (220)
Topical Live and Heat‐Killed Probiotics for Photoaging Prevention: A Meta‐Analysis
Dermatology Research and Practice, Volume 2026, Issue 1, 2026.Background The skin microbiome plays a crucial role in maintaining healthy skin, and imbalances in this microbial community, often caused by aging and environmental factors like UV radiation, are linked to photoaging. Topical probiotics may help prevent it.
Marina Rimadhani +5 more
wiley +1 more source
Structural basis for the activation of acid ceramidase
Nature Communications, 2018 Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insight ...
Ahmad Gebai +4 more
doaj +1 more source
Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis [PDF]
, 2019 Inflammatory diseases of the gastrointestinal tract are emerging as a global problem with increased evidence and prevalence in numerous countries. A dysregulated sphingolipid metabolism occurs in patients with ulcerative colitis and is discussed to ...
Becker, Katrin A. +9 more
core +1 more source
Characterization of genes involved in ceramide metabolism in the Pacific oyster (
BMC Research Notes, 2012 Background The lipid signaling molecule, ceramide, is a key component of the vertebrate stress response, however, there is limited information concerning its role in invertebrate species.
Timmins-Schiffman Emma, Roberts Steven
doaj +1 more source
Phylogenetic Analysis of Neutral Ceramidase
International Journal of Computer Applications, 2014 ceramidase (NCDase) plays an important role in cell regulation, and has been observed in most of the organism across different groups. In this study the molecular evolution of NCDase in different organisms was studied. The phylogenetic tree relationships among the organisms were explored by comparing the sequences of their NCDase.
Rufus Auxillia, Nirmal Rajah.R
openaire +1 more source
Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]
, 2019 Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra +3 more
core +1 more source
Role of neutral ceramidase in colon cancer
The FASEB Journal, 2016 ABSTRACT Alterations in sphingolipid metabolism, especially ceramide and sphingosine 1‐phosphate, have been linked to colon cancer, suggesting that enzymes of sphingolipid metabolism may emerge as novel regulators and targets in colon cancer.
Mónica, García-Barros +13 more
openaire +3 more sources
Regulation of apoptosis-associated lysosomal membrane permeabilization [PDF]
, 2010 Lysosomal membrane permeabilization (LMP) occurs in response to a large variety of cell death stimuli causing release of cathepsins from the lysosomal lumen into the cytosol where they participate in apoptosis signaling.
Ann-Charlotte Johansson +5 more
core +2 more sources
CDase is a pan-ceramidase inDrosophila
Molecular Biology of the Cell, 2011 Ceramidases catalyze the conversion of ceramide to sphingosine. They are acylaminohydrolases that catalyze the deacylation of the amide-linked saturated fatty acid from ceramide to generate sphingosine. They also catalyze the reverse reaction of ceramide biosynthesis using sphingosine and fatty acid.
Yuan, Changqing +9 more
openaire +3 more sources
Acid ceramidase confers radioresistance to glioblastoma cells
Oncology Reports, 2017 Glioblastoma multiforme (GBM) is the most common primary, intracranial malignancy of the central nervous system. The standard treatment protocol, which involves surgical resection, and concurrent radiation with adjuvant temozolomide (TMZ), still imparts a grim prognosis.
Doan, Ninh B. +9 more
openaire +3 more sources